Genetic markers of stress, resilience and success

Wednesday, January 21st, 2026

To qualify for training as elite U.S. Army Special Forces (SF) soldiers, candidates must complete the extremely stressful 19–20 day Special Forces Assessment and Selection (SFAS) course:

At SFAS, soldiers must excel at stressful cognitive and physical challenges including team problem solving, foreign language testing, land navigation, timed loaded road marches, timed runs, and challenging obstacle courses. Approximately 70% of soldiers who attempt SFAS fail.

To investigate genetic factors associated with cognitive and physiological biomarkers of resilience and success at SFAS, single nucleotide polymorphisms (SNPs; n = 116) from 47 genes associated with psychological function, resilience, circadian rhythms/sleep, and biomarkers of stress (cortisol and C-reactive protein [CRP]) were examined. Study volunteers were 800 males enrolled in SFAS (age=25±4y; height=178.1 ± 7.5 cm; body mass=82.5 ± 9.2 kg; mean±SD).

Genes associated with resilience and their functions included: tryptophan hydroxylase 2 (TPH2; serotonin synthesis); catechol-O-methyltransferase (COMT; catecholamine catabolism); corticotropin-releasing hormone receptor1 gene (CRHR1; resilience to stress); Period3 (PER3; circadian rhythmicity); FK506 binding protein5 (FKBP5; steroid receptor regulation).

In summary, several genetic variants are associated with cognitive function and resilience in healthy volunteers exposed to 19–20 days of severe physical and cognitive stress designed to select the best candidates for several years of training. This study extends findings of research on resilience genetics to a novel population and situation, mentally and physically stressed soldiers competing for the opportunity to be trained for an elite unit. The findings indicate that several genes known to be associated with resilience exert their effects on the resilience phenotype under very difficult circumstances than usually studied.

The family of birds that was rated most deliberate was herons; the family of birds that was rated quickest was swifts

Tuesday, January 20th, 2026

I Have Known the Eyes Already by Morgan WorthyAfter doing some content analyses, Morgan Worthy (I Have Known the Eyes Already) asked 100 ornithologists to make blind ratings of large families of birds on “quick-versus-deliberate” behavior related to flight, feeding, and escape:

Twenty-one agreed to do so. Some left out those families with which they were not very familiar.

I included in the analysis all large families of birds for which at least 15 ornithologists had made ratings. When size was partialed out, the eye-darkness measure and the combined behavioral measures correlated .56 [d.f. = 33, p < .001]. As you probably know, John, that means that differences in eye-darkness, even using a two-point scale, accounted for about 31% of the rated differences in quick-versus-deliberate behavior. That is not trivial. The family of birds that was rated most deliberate was herons; the family of birds that was rated quickest was swifts. Whereas the reaction time differences with humans were small in absolute terms, in this study of birds, the behavioral differences were large.

Simple reaction time is not related to skin color, but it is related to eye color

Sunday, January 18th, 2026

I Have Known the Eyes Already by Morgan WorthyMorgan Worthy explains (in I Have Known the Eyes Already) some independent research done at Pennsylvania State University by people he had never met:

They tested the reactivity hypothesis with human subjects by studying eye color and reaction time in a laboratory setting. They first found that simple reaction time is not related to skin color, but it is related to eye color. They found that dark-eyed blacks and dark-eyed whites have faster reaction times than do light-eyed whites. They then focused just on comparing dark-eyed Caucasians to light-eyed Caucasians on how quickly they could react to a visual or auditory stimulus. They did a number of well-controlled laboratory studies, and then did a meta-analysis of all those studies. Read this quotation which reports the results:

Thus, the findings across studies have consistently shown that dark-eyed subjects have shorter pre-motor time and simple RT latencies than light-eyed subjects. Considering that Worthy’s hypothesis has been experimentally tested seven times with seven different samples … a combined probability value would more accurately reflect the reliability of the eye color phenomenon. Using a z-transformation procedure … a z value was obtained that could not occur by chance any more than one time in 10 million. Worthy’s hypothesis, therefore, reliably predicts RT differences between eye color groups from one study to the next (Hale, et al. 1980, p. 61).

I can live with a probability of one in ten million that my hypothesis is wrong. I wanted you to read that in order to make it clear that the association between dark eyes and quick reactions is very well established in humans.

He concedes that the differences not large in absolute terms:

I had reached the same conclusion by studying performance records of professional and college athletes. Even small differences in the general population can matter when looking at a heavily selected group like professional athletes.

Amount of melanin in the iris is correlated with amount of neuromelanin in the central nervous system

Friday, January 16th, 2026

I Have Known the Eyes Already by Morgan WorthyThe amount of a black-brown pigment, eumelanin, in the iris is the main determinant of eye color, Morgan Worthy explains (in I Have Known the Eyes Already):

If there is a high enough concentration of eumelanin, the eye will appear brown. If the concentration is very high, the eye will appear black. If the particles of melanin are very small, a light-scattering effect will cause the iris to appear blue (for the same reason that the sky appears blue). Eye color is also determined by the amount of a yellow-red pigment, pheomelanin, in the iris. There are other factors involved, but that is the basic difference between dark eyes and light eyes. If you like, I can give you a recent article (Borteletti et al. 2003) that discusses various other factors that can influence iris color.

[…]

Amount of melanin in the iris is correlated with amount of melanin in the inner ear (Bonnaccorsi 1965) and with amount or distribution of neuromelanin in the central nervous system (Happy and Collins 1972). In terms of the link to motor behavior, it is perhaps significant that neuromelanin can function as a semiconductor (McGinness et al. 1974). Eye color is polygenic and the specific genetic causes are still being sorted out (Zhu et al. 2004). I just use eye color or eye darkness as a marker variable that is external and easily observed. In fact, eye color was used as a marker variable in many of the early studies of genetics.

One is a stalker; the other is a chaser

Wednesday, January 14th, 2026

I Have Known the Eyes Already by Morgan WorthyIf you are out in the yard with your pet, Morgan Worthy explains (in I Have Known the Eyes Already), and it sees a squirrel nearby, what it does next will probably depend on whether your pet is a cat or a dog:

The immediate response of a cat is to freeze, then crouch and start to stalk in preparation for an ambush. The immediate response of most dogs is to run, without delay, toward the squirrel and chase it. One is a stalker; the other is a chaser and uses immediate, direct pursuit. The first responses of cats and most dogs on sighting prey are very different from each other. Only after the prey has come close to the waiting cat or the cat has slowly worked its way close to the prey, does the cat suddenly pounce.

The typical dog makes quick moves; the cat makes sudden moves. Understanding the difference between those two words, quick and sudden, is necessary to understand everything else we will talk about. Quick implies an immediate reaction; sudden implies an abrupt move after some delay. The origins of the two words make this plain. “Quick” means “swift, lively.” “Sudden” means literally “to approach secretly” and comes from two Latin words that mean “secretly” and “to go.” One way to remember it is immediate quick and delayed sudden.

Another way to state this is that one is quick and the other is deliberate. If we can agree that most dogs tend to be quick and most cats tend to be deliberate, we can then move on to differences in eye darkness between the two. The reactivity hypothesis is that dark eyes are associated with quick responses and light eyes are associated with deliberate responses. Using our example, we can predict that dogs are darker-eyed than cats. A simple way to get a measure of eye darkness is to say that only brown eyes and black eyes are considered dark and all others are considered light.

[…]

Dogs tend to be significantly darker-eyed than cats. Of the 27 breeds of domestic cat, none are dark-eyed. They are all in the range of yellow-amber-orange-blue-green. None are at the other end of the scale—black, dark brown, brown—that we are treating as dark-eyed. The same is true for cats in the wild. Look with me here at the database (Worthy 2000, p44). In the wildlife literature we found eye colors for 15 species of cat. All had yellow or yellowish eyes except for one, the Ocelot, and its eyes are reddish brown. So, for 27 breeds of domestic cat and 15 species of cats in the wild, using our 2-point scale of eye darkness, every one of them gets a score of 0.

[…]

Most dogs react to prey by immediately giving chase. One group of dogs, though, employ an initial response to prey that is very much like the initial response of cats. Pointers and setters, like cats, freeze when they first sense prey nearby. Pointers adopt a standing pose and setters crouch. In regards to this initial response, I think any fair observer would grant that pointers and setters are more deliberate or cat-like than are other dogs. If the reactivity hypothesis is correct, those breeds (all are often just referred to as Pointers) should be less likely than other breeds to have dark eyes. That is, indeed, the case. Whereas 70% of other breeds are dark-eyed, only 28% of the pointer or setter breeds are dark-eyed. A difference that large, given the sample sizes, could occur by chance less than one time in a thousand.

[…]

Pointers are bred for “freezing” as first response to prey; hounds are bred to track and chase prey; terriers are bred for not only chasing the prey, but for following it into burrow or den—which requires a high level of persistence and courage. Simon & Shuster’s Guide to Dogs (Pugnetti 1980) uses a symbol to indicate adaptation for each of those three behaviors.

There is a progression. Fifty-five per cent of pointer breeds have yellowish eyes; for hounds, it is only 10%, and there is no breed of terrier that has yellowish eyes. Yellow eyes seem to be associated with hesitation or freezing behavior, which is good for animals that stalk. Hesitation would tend to be a liability for animals that hunt by means of direct pursuit. And that would be especially true for terriers, which are expected to pursue the prey into its den.

[…]

Dark-eyed animals show active courage; light-eyed animals that freeze when predators are near show passive courage.

One of the main things to remember, though, from our talking about cats and dogs, is that predators that depend a lot on freezing, ambush, lying-in-wait, stalking, or any other form of surprise to take prey will not only be light-eyed, but most likely will have yellowish eyes. I know we have only covered three examples so far—domestic cats, cats in the wild, and dogs that point or set—but the same pattern is seen with all classes of land vertebrates. Any type predator that uses surprise to ambush prey (in less than total darkness) tends to have yellowish eyes. That can be noted by anyone who cares to look within various orders or sub-orders of animals: frogs, snakes, lizards, crocodilians, carnivores, primates, raptors, owls, heron-like birds, and various other orders of birds.

No one can deny that statement, but they can ignore it. Given human history, people of good will are now reluctant to acknowledge any evidence that pigmentation can be related to behavior. We seem always to go from one extreme to the other.

[…]

Helen Mahut (1958) did a study in Canada in which she compared ten breeds of dog on response to novel stimuli and categorized the behavior as “fearless” or “fearful,” depending on how bold or inhibited the dogs were in their responses. I no longer remember the particular breeds, but when I checked the eye colors, the most fearless dogs were also the ones with the darkest eyes.

[…]

Asdell (1966) described wolves as being cautious, cowardly and fearful of novel stimuli. They pursue prey in a circling or zigzag manner in order to set up an ambush. That is not direct pursuit as is seen in terriers or weasels. Nor is it as non-reactive as the behavior of cats and pointers. Because wolves are lighter eyed than most dogs it is significant that Asdell also reported that wolf-dog hybrids exhibit “passive defense reactions” more than do most dogs.

Yellow-eyed predators use a tactic of wait without moving

Friday, January 9th, 2026

I Have Known the Eyes Already by Morgan WorthyMorgan Worthy, in the opening to his memoir, I Have Known the Eyes Already, explains his hypothesis about eye-color:

One day, probably in early 1971, I was looking through a magazine dealing with (American) professional football. I noticed, once again, that there were many African-American players who had made it to this advanced level of skill and that they were not evenly distributed across all positions. As I neared the end of the magazine, I had the strange, vague, feeling of being reminded of some remote association. I had lingered on this page looking at a photograph of a white player with very light eyes. Then I had my aha moment: earlier in looking at the magazine I had stopped to look at another photograph of a white player with very light eyes, and in both cases the player was a quarterback. Now I recognized, consciously, what had unconsciously caused the vague feeling of remote association. Of course, it might have been a coincidence not worth remembering at all, but then again, I had learned, in military intelligence, to pay attention to even minimal bits of matching information.

Almost at once, I began to wonder if white players at different positions had different levels of average eye darkness and, if so, whether this rank order of positions was positively correlated to the rank order of positions based on percentage of African-Americans playing the position. When I later tested my speculations, the answer was “yes”, on both counts. The two rank orders were positively and significantly correlated and both had quarterbacks at one extreme, with defensive backs at the other.

Defensive backs (especially those playing man-to-man) are much more dependent on immediate, quick reactions than are quarterbacks, who depend more on delayed, sudden reactions. Having already been thinking about the role of quick reactions in sports for several years, I jumped to the potential conclusion (i.e. hypothesis) that dark eyes are associated with the ability to make quick reactions. That started me thinking some more.

It occurred to me that eye darkness (not race or skin color) was the key dimension that could incorporate all the data. I thought in terms of eye darkness rather than eye color because, fortunately, I had been looking at black and white photographs in the magazine.

Also, it occurred to me that eye darkness, as a variable to study scientifically, had the advantage, unlike race, of retaining similar meaning across species. The more I thought about it, the more I thought of eye color, or eye darkness, as potentially important in scientific research.

[…]

A series of studies were done at Penn State University by Daniel Landers and his colleagues to test what has been called the “Worthy reactivity hypothesis.” This is my idea that dark eyes are associated with quick reactions. (The hypothesis is not suggesting anything about you or anyone else as an individual.) After finding the hypothesis confirmed in seven straight studies using laboratory equipment designed to detect small differences in reaction time, they calculated that the chance that dark eyes are not associated with quick reactions is less than one in ten million. I can live with those odds of being wrong.

They demonstrated that the results were not related to differences in skin color. It is an eye-darkness phenomenon. Most of their studies involved comparing brown-eyed Caucasians with blue-eyed Caucasians.

[…]

Partly because the differences between humans were small in absolute terms, I started in the 1970s to collect, mostly from field guides, published information on eye color for different species of land vertebrates. By the time this database, in its final form, was published in 2000, my wife and I had found published information on eye colors for 5,620 species of land vertebrates. Thousands were species of birds, hundreds were species of amphibians, reptiles or mammals. I need to make clear that my reactivity hypothesis is intended, now, to apply only to adult land vertebrates–not children, fish or invertebrates.

After comparing eye color information to behavioral information, it seems to me that the pattern holds across all classes of land vertebrates. One can see this by looking, first, at birds and bats. It is only the darkest-eyed families (mostly comprised of species with black or dark brown iris colors) that specialize in feeding on the wing in an open environment. That behavior is very dependent on speed and quick reactions. At the human level, that is analogous to outfielders in baseball; they, too, must have the speed, quick reactions, and developed skills to catch flies in an open environment.

At the other extreme, lightest-eyed, one finds herons. Their eye colors are mostly not dark at all, but yellowish, as are the eyes of families of frogs, cats, geckos and vipers. (These are the lightest-eyed large families in our database and come from all four classes of land vertebrates.) These animals are all hunters that lie-in-wait or slowly stalk prey before a sudden strike or pounce. All have some form of spring-loaded anatomy, such as folded neck, coiled tongue, or coiled body, that aids in making a sudden strike. At the human level, this is somewhat analogous to a slow-running quarterback in American football who, nevertheless, manages to be successful because of his ability and developed skill to just wait, with cocked arm, in a “pocket” of blockers, until the right moment to make a sudden strike downfield to an open receiver. Waiting, good timing and sudden release are all critical elements in the sequence.

It is easy enough to see in nature that yellow-eyed predators and black-eyed predators differ. Yellow-eyed predators use a tactic of WAIT WITHOUT MOVING. Black-eyed predators, such as those that feed on the wing, rely on a tactic of MOVE WITHOUT WAITING. Animals with eye darkness in the midrange between yellowish colors and dark brown or black (blue, green, gray, orange, red, hazel, light brown, brown) tend not to be skilled hunters, but, rather, rely more on finding immobile food (e.g. fruit, carrion, grubs, grass, eggs, ants, spiders). I have characterized this behavior as self-paced, or CAN WAIT. At least on the timing dimension, this is analogous in human sports to activities that are self-paced, such as pitching in baseball, shooting free throws in basketball, and the sports of golf and bowling.

[Land vertebrates that can hunt in total darkness tend to be dark-eyed and rely heavily on KEEN senses other than vision-such as hearing (e.g. Barn owls), touch (e.g. Boat-billed heron) or smell (e.g. pittas).]

To make sure that I was not “cherry-picking” my observations, I had twenty-one ornithologists make blind ratings of quick-versus-deliberate behavior for large families of birds. Those ratings confirmed that, in birds, controlling for differences in size, light eyes were associated with deliberate behavior and dark eyes were associated with quick behavior. Herons were rated as most deliberate and swifts received the highest ratings for quickness.

Microbes may hold the key to brain evolution

Wednesday, January 7th, 2026

In a controlled lab experiment, researchers implanted gut microbes from two large-brain primate species (human and squirrel monkey) and one small-brain primate species (macaque) into microbe-free mice:

Within eight weeks of making changes to the hosts’ microbiomes, they observed that the brains of mice with microbes from small-brain primates were indeed working differently than the brains of mice with microbes from large-brain primates.

In the mice with large-brain primate microbes, the researchers found increased expression of genes associated with energy production and synaptic plasticity, the physical process of learning in the brain. In the mice with smaller-brain primate microbes, there was less expression of these processes.

“What was super interesting is we were able to compare data we had from the brains of the host mice with data from actual macaque and human brains, and to our surprise, many of the patterns we saw in brain gene expression of the mice were the same patterns seen in the actual primates themselves,” Amato said. “In other words, we were able to make the brains of mice look like the brains of the actual primates the microbes came from.”

Another surprising discovery the researchers made was a pattern of gene expression associated with ADHD, schizophrenia, bipolar and autism in the genes of the mice with the microbes from smaller-brain primates.

Not so blinding as New Mexico test because of bright sunlight

Sunday, January 4th, 2026

Now It Can Be Told by Leslie M. Groves At about 4:30 a.m. the Duty Officer delivered General Groves the detailed hoped-for cable from Farrell, as Groves explains (in Now It Can Be Told: The Story of the Manhattan Project), which had been dispatched after the bomber returned to Tinian. It read:

Following additional information furnished by Parsons, crews, and observers on return to Tinian at 060500Z. Report delayed until information could be assembled at interrogation of crews and observers. Present at interrogation were Spaatz, Giles, Twining, and Davies.

Confirmed neither fighter or flak attack and one tenth cloud cover with large open hole directly over target. High speed camera reports excellent record obtained. Other observing aircraft also anticipates good records although films not yet processed. Reconnaissance aircraft taking post-strike photographs have not yet returned.

Sound—None appreciable observed.

Flash—Not so blinding as New Mexico test because of bright sunlight. First there was a ball of fire changing in a few seconds to purple clouds and flames boiling and swirling upward. Flash observed just after airplane rolled out of turn. All agreed light was intensely bright and white cloud rose faster than New Mexico test, reaching thirty thousand feet in minutes it was one-third greater diameter.

It mushroomed at the top, broke away from column and the column mushroomed again. Cloud was most turbulent. It went at least to forty thousand feet. Flattening across its top at this level. It was observed from combat airplane three hundred sixty-three nautical miles away with airplane at twenty-five thousand feet. Observation was then limited by haze and not curvature of the earth.

Blast—There were two distinct shocks felt in combat airplane similar in intensity to close flak bursts. Entire city except outermost ends of dock areas was covered with a dark grey dust layer which joined the cloud column. It was extremely turbulent with flashes of fire visible in the dust. Estimated diameter of this dust layer is at least three miles. One observer stated it looked as though whole town was being torn apart with columns of dust rising out of valleys approaching the town. Due to dust visual observation of structural damage could not be made.

At no time was there any idea of testing the gun-type bomb

Monday, December 29th, 2025

Now It Can Be Told by Leslie M. Groves In late June, as the forces under General MacArthur and Admiral Nimitz approached within bombing range of the Japanese homeland, General Groves realized that they had not been told about the ban on certain cities, as he explains (in Now It Can Be Told: The Story of the Manhattan Project), for at the time it was imposed they had been too far away to make it necessary:

This concern was soon removed, however, for when we brought the matter to the attention of the Joint Chiefs, they hastily reserved our targets from all air attack.

We were fairly sure by now that we would be able to test the Fat Man, the implosion-type bomb, sometime around the middle of July. (At no time was there any idea of testing the gun-type bomb.) Planning for this operation, which carried the code name of Trinity, had begun back in the spring of 1944 when Oppenheimer and I decided that a test might be necessary to make certain that the complex theories behind the implosion bomb were correct, and that it was soundly designed, engineered, manufactured and assembled—in short, that it would work.

We thought then that we might want to explode the first bomb inside a container, so that if a nuclear explosion did not take place or if it was a very small one, we might be able to recover all or much of the precious plutonium. Also, we wanted to prevent its being scattered over a wide area and creating a health hazard that would make it necessary to guard the area against trespassers for many years.

Consequently we ordered from Babcock and Wilcox a heavy steel container, which because of its great size, weight and strength was promptly christened Jumbo. To move it from the manufacturing plant in the East to New Mexico, it had to be loaded onto specially reinforced cars and carefully routed over the railroads. At the nearest railroad stop to the test site it was unloaded onto a specially built trailer with some thirty-six large wheels, and then driven overland about thirty miles to Alamogordo.

But by the time of the test we had decided we would not need to use Jumbo, for we had learned enough to be reasonably certain of a fair-sized nuclear explosion. Even if it were as low as 250 tons, as many of our scientists were predicting, the container would only create additional dangers.

It is interesting to speculate about what would have happened, with the actual explosion of almost twenty thousand tons, if we had used Jumbo. That the heat would have completely evaporated the entire steel casing is doubtful. If it did not, pieces of jagged steel would probably have been hurled for great distances.

The scientist in charge of the test was Dr. K. T. Bainbridge, who had the unusual qualification of being a physicist with undergraduate training in electrical engineering.

[…]

I had ruled out using Los Alamos for the test on grounds of security and also because I doubted if the area could be expanded sufficiently. Later, we decided that we would need a site measuring approximately seventeen by twenty-four miles, that it should be in a generally non-populated area, and that it should be no further from Los Alamos than necessary. I added one special prohibition: that it should have no Indian population at all, for I wanted to avoid the impossible problems that would have been created by Secretary of the Interior Harold L. Ickes, who had jurisdiction over the Bureau of Indian Affairs. His curiosity and insatiable desire to have his own way in every detail would have caused difficulties and we already had too many.

[…]

Air travel has improved considerably since those days. The field we used at Pasadena was very small, and our approach to it was impeded by some high-tension lines at the end of the strip. As he came in, our pilot found himself lined up on the taxiway and quite low. Instead of circling the field, he came in over the wires and then side-slipped, landing with a terrific bounce—both horizontal and vertical. Our landing brought everyone out of the small operations office, including one of my security officers who had missed the plane in San Francisco, and who was waiting to rejoin us in Pasadena. He remarked afterward that, if not the first, at least the second thought that flashed through his mind was: “How am I going to explain the accidental death of Bush, Conant and Groves, without publicity to the project and resulting breaches of security?”

We left the next morning from March Field in Riverside in order to be sure that the predicted Los Angeles fog would not interfere with our taking off.

[…]

The main problem was the weather. We had obtained the very best men that the armed forces had on long-range weather forecasting, and, for a considerable period, they had been making accurate long-range weather predictions for the test site. The only time they were not right was on the one day that counted. The weather that evening was quite blustery and misty, with some rain. Fortunately, the wind seemed to be in the right direction.

We were interested in the weather for a number of reasons: First and foremost, we wanted to avoid as much radioactive fallout2 as possible, particularly over populated areas. This was a matter that had not received any attention until about six months earlier, when one of the Los Alamos scientists, Joseph Hirschfelder, had brought up the possibility that it might be a real problem. For this reason, we felt it would be desirable to explode the bomb when rain was unlikely, since rain would bring down excessive fallout over a small area instead of permitting it to be widely distributed and therefore of little or no consequence. In reaching this decision we could not ignore the old reports that heavy battle cannonading had sometime brought on rain, even though no scientific basis was known for a such phenomenon.

Second, it was extremely important that the wind direction be satisfactory, because we did not want the cloud, if one developed, to pass over any populated areas until its radioactive contents were thoroughly dissipated. It was essential that it not pass over any town too large to be evacuated. The city about which we were most concerned was Amarillo, some three hundred miles away, but there were others large enough to cause us worry. The wind direction had to be correct to within a few degrees.

Third, we wanted suitable flying weather so that we could have observation planes flying over the near-by areas; and finally, we wanted to avoid prior heavy rain or continuous dampness, which might ruin our electrical connections, both for firing the bomb, and for the various instruments.

[…]

I was extremely anxious to have the test carried off on schedule. One reason for this was that I knew the effect that a successful test would have on the issuance and wording of the Potsdam ultimatum. I knew also that every day’s delay in the test might well mean the delay of a day in ending the war; not because we would not be ready with the bombs, for the production of fissionable material would continue at full tilt anyway, but because a delay in issuing the Potsdam ultimatum could result in a delay in the Japanese reaction, with a further delay to the atomic attack on Japan. Obviously, a reasonable time had to be allowed for the Japanese to consider the ultimatum.

From a purely technical point of view, also, it was desirable to avoid a postponement, for the chances of short circuits and a misfire would increase appreciably with every hour that our connections were subjected to excessive moisture.

[…]

It had originally been scheduled for 4 a.m. on July 16. This hour had been fixed with the thought that an explosion at that time would attract the least attention from casual observers in the surrounding area, since almost everyone would be asleep. We expected there would be a tremendous flash of light, but thought it would not be great enough to waken many people who were well removed from the burst. Then, too, we wanted the darkness for our photography.

[…]

As the hour approached, we had to postpone the test—first for an hour and then later for thirty minutes more—so that the explosion was actually three and one half hours behind the original schedule. While the weather did not improve appreciably, neither did it worsen. It was cloudy with light rain and high humidity; very few stars were visible. Every five or ten minutes, Oppenheimer and I would leave the dugout and go outside and discuss the weather. I was devoting myself during this period to shielding Oppenheimer from the excitement swirling about us, so that he could consider the situation as calmly as possible, for the decisions to be taken had to be governed largely by his appraisal of the technical factors involved.

[…]

Everyone was told to lie face down on the ground, with his feet toward the blast, to close his eyes, and to cover his eyes with his hands as the countdown approached zero. As soon as they became aware of the flash they could turn over and sit or stand up, covering their eyes with the smoked glass with which each had been supplied.

[…]

As I lay there, in the final seconds, I thought only of what I would do if, when the countdown got to zero, nothing happened. I was spared this embarrassment, for the blast came promptly with the zero count, at 5: 30 A.M., on July 16, 1945.

My first impression was one of tremendous light, and then as I turned, I saw the now familiar fireball. As Bush, Conant and I sat on the ground looking at this phenomenon, the first reactions of the three of us were expressed in a silent exchange of handclasps. We all arose so that by the time the shock wave arrived we were standing.

I was surprised by its comparative gentleness when it reached us almost fifty seconds later. As I look back on it now, I realize that the shock was very impressive, but the light had been so much greater than any human had previously experienced or even than we had anticipated that we did not shake off the experience quickly.

Unknown to me and I think to everyone, Fermi was prepared to measure the blast by a very simple device. He had a handful of torn paper scraps and, as it came time for the shock wave to approach, I saw him dribbling them from his hand toward the ground. There was no ground wind, so that when the shock wave hit it knocked some of the scraps several feet away. Since he dropped them from a fixed elevation from near his body which he had previously measured, the only measurement he now needed was the horizontal distance that they had traveled. He had already calculated in advance the force of the blast for various distances. So, after measuring the distance on the ground, he promptly announced the strength of the explosion. He was remarkably close to the calculations that were made later from the data accumulated by our complicated instruments.

I had become a bit annoyed with Fermi the evening before, when he suddenly offered to take wagers from his fellow scientists on whether or not the bomb would ignite the atmosphere, and if so, whether it would merely destroy New Mexico or destroy the world. He had also said that after all it wouldn’t make any difference whether the bomb went off or not because it would still have been a well worth-while scientific experiment. For if it did fail to go off, we would have proved that an atomic explosion was not possible. Afterward, I realized that his talk had served to smooth down the frayed nerves and ease the tension of the people at the base camp, and I have always thought that this was his conscious purpose. Certainly, he himself showed no signs of tension that I could see.

[…]

These plans proved utterly impracticable, for no one who had witnessed the test was in a frame of mind to discuss anything. The reaction to success was simply too great. It was not only that we had achieved success with the bomb; but that everyone—scientists, military officers and engineers—realized that we had been personal participants in, and eyewitnesses to, a major milestone in the world’s history and had a sobering appreciation of what the results of our work would be. While the phenomenon that we had just witnessed had been seriously discussed for years, it had always been thought of as a remote possibility—not as an actuality.

[…]

Several days after I got back to Washington, Dr. R. M. Evans, of the du Pont Company, came to see me about some of the operating problems at Hanford. After we had finished and as he was leaving, he turned, his hand on the doorknob, and said, “Oh, by the way, General, everybody in du Pont sends you their congratulations.” I quickly replied, “What are you talking about?” He answered, “It’s the first time we ever heard of the Army’s storing high explosives, pyrotechnics and chemicals in one magazine.” He went on to add that the radio announcement on the Pacific Coast had been teletyped in to Wilmington from Hanford. My only response was: “That was a strange thing for the Army to do, wasn’t it?”

[…]

Mr. Stimson’s diary for Sunday, July 22, 1945, is most enlightening:

Churchill read Groves’ report in full. He told me that he had noticed at the meeting of the Three yesterday that Truman was much fortified by something that had happened, that he had stood up to the Russians in a most emphatic and decisive manner, telling them as to certain demands that they could not have and that the United States was entirely against them. He said, “Now I know what happened to Truman yesterday. I couldn’t understand it. When he got to the meeting after having read this report, he was a changed man. He told the Russians just where they got on and off and generally bossed the whole meeting.” Churchill said he now understood how this pepping up had taken place and he felt the same way.

Reindeer eyes change hues with the seasons

Sunday, December 28th, 2025

In 2013, scientists discovered that reindeer eyes change hues with the seasons:

If you look into the eyes of an Arctic reindeer (Rangifer tarandus) in the summer, when the days are long and the Sun is bright, you will see shining back a gold and turquoise glow, similar to the emerald reflection of cats’ eyes in the night.

In wintertime, however, when darkness reigns, a reindeer’s eye does something unique. It turns a stunning, deep blue.

[…]

Reindeer feed at twilight, and during the Arctic winter, twilight can last for more than a third of the day, casting an extremely blue light over the icy landscape.

[…]

To aid in the reindeer’s ability to see lurking wolves and yummy lichen in the dimness, scientists think that the animal’s eyes may have evolved to reflect more blue light in winter. This gives the low light another pass through the retina, allowing more information to be gleaned by the eye’s photoreceptors.

As such, the reindeer gets a brighter view of the twilit landscape (up to a thousand times brighter), but the trade-off is an image with significantly less resolution, like looking through misted glass.

[…]

In 2022, Fosbury and colleagues studied the difference between the eyes of reindeer that had died in summer and those that had died in winter.

Their findings support the idea that constant dilation of the pupils in low light affects the eyes’ fluid balance, possibly causing structural changes in the tapetum.

When it remains activated too long, it diverts the body’s resources from normal growth and development toward cellular defense

Monday, December 22nd, 2025

Dr. Robert Naviaux, a professor of medicine, pediatrics and pathology at UC San Diego School of Medicine, suggests that a built-in stress response, called the cell danger response (CDR), might explain autism:

The review pulls together more than ten years of research across genetics, metabolism, toxicology and early brain development.

[…]

The first hit is genetic predisposition: some children inherit a “sensitive genotype” that makes their mitochondria and cellular signaling systems highly reactive to environmental changes. These can range from specific genetic syndromes to a combination of common variants. On their own, these genetic traits do not cause autism, but they create biological hypersensitivity to stress.

The second hit occurs when the environment triggers this sensitivity. This happens during a critical window from early pregnancy through the first 18–36 months of life. Triggers can include maternal immune activation, pollution or metabolic stressors. In this model, early triggers push sensitive cells into a stress state at the wrong moment.

The third hit is when that stress state continues for months during late pregnancy or early childhood. Long periods of cellular stress are proposed to disturb normal brain development, reshape mitochondria and influence gut microbes and the immune system.

Across these three hits, one mechanism ties the model together: a signaling molecule called extracellular ATP (eATP), a molecule that acts as a “danger signal”. When eATP levels stay high, cells remain in a defensive mode rather than returning to normal growth. Naviaux argues that this is not a malfunction, but rather mitochondria responding exactly as designed to a perceived threat.

“Behavior has a chemical basis. The CDR regulates that chemistry,” Naviaux explained. “When it remains activated too long, it diverts the body’s resources from normal growth and development toward cellular defense, leaving fewer resources for the developing brain.”

The review explains that the CDR is part of a universal healing cycle called salugenesis; in autism, this cycle gets stuck, preventing the return to normal cellular function. This prolonged stress prevents the necessary developmental shift from excitatory to inhibitory signaling in the brain, leading to over-excitation.

This framework also explains why many autistic children experience physical symptoms such as gut issues or sleep disturbances – signs of a body-wide stress response.

The development of nuclear energy in Germany never got beyond the laboratory stage

Sunday, December 21st, 2025

Now It Can Be Told by Leslie M. GrovesBoris Pash, leader of the Alsos Mission, was about twenty miles ahead of the advanced elements of the Seventh Army, General Groves explains (in Now It Can Be Told: The Story of the Manhattan Project), as they pushed through the Bavarian Alps:

Finding the bridge into Urfeld destroyed, his group of eight dismounted from their vehicles and joined a ten-man reconnaissance patrol, entering Urfeld in the late afternoon of May 2. About an hour later, a German unit tried to pass through the town and a hot fire fight broke out. Shortly afterward, the patrol withdrew, leaving Pash in control of the town but alone. I could never straighten out in my own mind just what happened that night. But the following will give a general picture.

At sundown Pash was told that a German general wished to see him. The general was admitted and immediately surrendered his entire division to the very surprised chief of the Alsos mission. Pash, thinking fast, replied that it was getting late and he did not wish to bother his own general, who was right behind him with a large force, with any formalities that night; so the Germans would have to wait until morning to have their surrender officially accepted. No sooner had the first general departed than another German commander, this time of seven or eight hundred men, arrived and the procedure was repeated. By now, Pash was thoroughly alarmed for the safety of his infinitesimal force, and, as soon as it became thoroughly dark, he withdrew quietly toward the American lines. Shortly before this he had found Heisenberg, but with the difficult situation confronting him he felt it wiser to leave him in his home for the time being. During the night, he was able to obtain the support of an infantry battalion. He returned at dawn on May 3 and picked up Heisenberg, who was waiting in an office with his bag already packed. When Pash entered, Heisenberg greeted him with: “I have been expecting you.” Heisenberg was immediately evacuated to Heidelberg.

Pash’s last effort typified the boldness with which he carried out every one of his operations, and clearly demonstrated his ability to stick to his objective, which, in this case, had been to catch Heisenberg. Heisenberg was one of the world’s leading physicists and, at the time of the German break-up, he was worth more to us than ten divisions of Germans. Had he fallen into Russian hands, he would have proven invaluable to them. As it was, he has always remained on the side of the West. Judging from other actions taken at that time, we seemed to be almost alone in our appreciation of the potential value of German scientists to the Russians. With Heisenberg in our custody, all his colleagues began to talk freely. We soon learned that, although Gerlach had been in administrative charge of the work, he had only a superficial knowledge of its technical details. Diebner was not particularly co-operative and seemed to be rather antagonistic toward Heisenberg. Gerlach and Heisenberg were on cordial terms and appeared to consider Diebner an inferior scientist. Heisenberg was, outwardly at least, actively anti-Nazi, but was nevertheless strongly nationalistic. None of them seemed to know very much about the Allies’ nuclear fission efforts; Gerlach spoke several times of the poor quality of German technical intelligence. There was no German counterpart of Alsos.

After Hamburg fell, Harteck was captured. He had written a letter on April 24, 1939, in which he advised the War Ministry that:

We take the liberty of calling to your attention the newest development in nuclear physics which in our opinion will perhaps make it possible to produce an explosive which is many orders of magnitude more effective than the present one … it is obvious that if the possibility of energy production outlined above can be realized, which certainly is within the realm of possibility, that country which first makes use of it, has an unsurpassable advantage over the others.

However, Harteck, like the other German scientists, seemed to have come to feel that, while there was some hope of producing energy from a uranium pile, it was unlikely, if not entirely impossible, that a workable weapon could be developed. The various possibilities open to the Germans were never systematically and completely investigated. This was because their work was seriously deficient in over-all direction, unity of purpose and coordination between the participating agencies. Originally, there had been a number of more or less competing groups, one under Army Ordnance, another under the Kaiser Wilhelm Institute of Physics, and still another under the Postal Department.

There was continual bickering, as might be expected, over supplies and material, and surprisingly enough, in the light of most American scientists’ pleas for freedom from the restrictions of compartmentalization, there was a generally nonco-operative attitude regarding the exchange of information between the various groups. Many German scientists worked alone on their individual projects and did not seem to feel any compulsion to work for the national interest. The basic reason for this was probably the generally accepted belief that the development of a nuclear weapon was not possible.

In any case, the development of nuclear energy in Germany never got beyond the laboratory stage, and even there the principal consideration was its use for power rather than for explosives. Other scientific objectives seemed to be more important and received greater governmental attention and support.

The status of the German effort at the close of the war in Europe was reminiscent of the early phases of our project in the United States, when committees were appointed only to be superseded by other committees. At times it seemed as though more thought had to be devoted to organization than to solving the problems under study.

Boris Pash led an interesting life:

Boris Fedorovich Pashkovsky was born in San Francisco, California, on 20 June 1900. His father was Reverend Theodore Pashkovsky (who would become Most Reverend Metropolitan Theophilus from 1934 to 1950), a Russian Orthodox priest and later archbishop who had been sent to California by the Church in 1894.

[…]

One of Boris´s earliest memories was of the 1906 San Francisco earthquake.

His father was recalled to Russia in 1906, and the entire family returned to Russia in 1913.

In 1916–1917, both father and son joined the ranks of the Russian army as it fought against Germany and the Austro-Hungarian Empire in World War I: Theodore – as a military chaplain, and 16-year-old Boris – as an artillery private to the 52nd Infantry Division. During the Russian Revolution, the family fled to Simferopol, Crimea, where Boris worked for the YMCA. By February 1920, Boris joined the White navy in the Black Sea and served on the navy cruiser General Kornilov. Boris saw action against the Bolsheviks at sea, and in March 1920, he was awarded the Cross of St. George, fourth class.

On 1 July 1920, he married Lydia Vladimirovna Ivanova, and chose to return to the United States when the Bolshevik consolidation of power became apparent. He was able to secure employment with the YMCA in Berlin, where his son Edgar Constantine Boris Pashkovsky was born on 14 June 1921.

Upon returning to the United States with his family in 1923, he attended Springfield College, in Springfield, Massachusetts, where he graduated with a Bachelor of Physical Education. It was during this time that he changed the family name from Pashkovsky to Pash.

Pash taught and coached baseball at Hollywood High School in Los Angeles from 1924 until 1940, where students included Lana Turner, Judy Garland, and Mickey Rooney. During this time he continued his education, receiving a Master of Science in Education from the University of Southern California in 1939. He also joined the United States Army Reserve, and was assigned to the Infantry Intelligence Branch. As part of his training, he qualified for certification by the Federal Bureau of Investigation.

German scientists did not support their country in the war effort

Friday, December 19th, 2025

Now It Can Be Told by Leslie M. GrovesIt was quite interesting, General Groves explains (in Now It Can Be Told: The Story of the Manhattan Project), to watch the pattern of the total German scientific effort emerge:

I have always considered Goudsmit’s opinion much to the point: “On the whole, we gained the definite impression that German scientists did not support their country in the war effort. The principal thing was to obtain money from the government for their own researches, pretending that they might be of value to the war effort. One genuine selling point which they used extensively was that pure research in Germany in many fields was far behind the United States.”

Although most of our objectives in Germany lay in the French zone of advance, one that was particularly important to us — the Auer-gesellschaft Works in Oranienburg, about fifteen miles north of Berlin — lay in what was to be the Russian zone. The information that Alsos had uncovered in Strasbourg had confirmed our earlier suspicions that the plant was engaged in the manufacture of thorium and uranium metals which were to be used in the production of atomic energy and hence probably for the manufacture of an atomic bomb. Since there was not even the remotest possibility that Alsos could seize the works I recommended to General Marshall that the plant be destroyed by air attack.

When he approved, I sent Major F. J. Smith, of my office, to explain the mission to General Carl Spaatz, who was then in command of our Strategic Air Forces in Europe. Spaatz co-operated wholeheartedly and, in a period of about thirty minutes during the afternoon of March 15, 612 Flying Fortresses of the Eighth Air Force dropped 1,506 tons of high explosives and 178 tons of incendiary bombs on the target. Poststrike analysis indicated that all parts of the plant that were aboveground had been completely destroyed. Our purpose in attacking Oranienburg was screened from Russians and Germans alike by a simultaneous and equally heavy attack upon the small town of Zossen, where the German Army’s headquarters were situated. I have since learned that as an entirely unexpected bonus the Zossen raid incapacitated General Guderian, then Chief of the German General Staff.

[…]

[T]he experimental uranium pile at Berlin Dahlem had been removed to Haigerloch, another small town near Hechingen. They reported a shortage of heavy water, explaining that their only source of it had been in Norway. The pieces of the puzzle were beginning to fall into place at last.

Bothe disclosed that the total German effort on atomic physics had consisted of himself and three helpers: Heisenberg with ten men; Dopel in Leipzig, assisted by his wife; Kirchner in Garmisch with possibly two assistants; and Stetter in Vienna with four or five others. Hahn, he said, was engaged in work on chemical problems.

The Heidelberg group told us that Gerlach’s approval was required before any physicist could obtain the means for scientific work. If he wanted the highest priority rating, called DE, he had to have the additional approval of Albert Speer, Minister of Armaments and Munitions.

Later, Bothe expressed his belief that the separation of uranium isotopes by thermal diffusion was impossible and indicated that the only work on isotope separation being done in Germany involved the centrifugal method. He added that this work was under the direction of Dr. Harteck. Bothe said he knew of no element higher than 93, although he recognized that since element 93 was a beta emitter, 94 must exist. He repeatedly expressed his opinion that the uranium pile as a source of energy was decades away and that the use of uranium as an explosive was altogether impracticable. He claimed not to know of any theoretical or experimental work being done in Germany on the military applications of atomic fission, but he agreed that such work could be under way without his knowledge.

After repeated questioning about the military value of the cyclotron, Bothe admitted that it had been regarded as a means for obtaining radioactive material for bombs.

[…]

Some of his personal letters, however, did cast doubts upon his assertion that he knew nothing of the work being done at Bisingen and Sigmaringen. From other sources, the interrogators learned that Bothe had returned a considerable quantity of uranium to Degussa after he had no further use for it.

Kuhn was present throughout Bothe’s interrogation. When it was over, he called one of the Alsos men aside and told him about the technical and scientific library of the German Chemical Society, of which he was the custodian. He claimed that it was the best of its kind in the world and included accounts of most of the German chemical activities in the war. To avoid the risks of heavy bombing, the library had been concealed in a number of caves and eventually was moved to a salt mine. Quite evidently, Kuhn preferred to have it taken over by the Americans rather than by the Russians. Unfortunately, it was behind the Russian lines.

[…]

Gertner said that he had worked with Joliot in Paris, from September of 1940 to July of 1943. He and Joliot, who had been close friends, had discussed the possibility of an atomic bomb and they had agreed that its development was not feasible.

[…]

He had reached the conclusion that it would be impossible to develop an atomic bomb because of the difficulties involved in separating isotopes. He further believed that, of all the separation methods, the centrifuge process offered the best prospects of success, but the low production rates that had been achieved by that method appeared to rule it out.

[…]

At about this time a major problem arose in Washington. The division of Germany into three zones of occupation had been arranged at Yalta. Later, when it was decided to establish a fourth zone to be occupied by the French, the readjustment of the American zone’s boundaries was handled by a committee of representatives of the State Department and of the Joint Chiefs of Staff. All the information that had been developed by Alsos indicated that the principal German work on atomic energy was being conducted in the general area Freiburg-Stuttgart-Ulm-Friedrichshafen, a large part of which would be turned over to the French. Hechingen lay near the center of this area and was in the French Army’s zone of advance, far removed from the zone of any American unit.

As I saw it, there could be no question but that American troops must be the first to arrive at this vital installation, for it was of the utmost importance to the United States that we control the entire area that contained the German atomic energy activities.

[…]

Consequently, I was forced to initiate some drastic measures to accomplish our purpose. One of these became known as Operation Harborage.

According to this plan, American troops would have to get into and hold the area long enough for us to capture the people we wanted, question them, seize and remove their records, and obliterate all remaining facilities, for my recent experiences with Joliot had convinced me that nothing that might be of interest to the Russians should ever be allowed to fall into French hands. Having reached this conclusion, I discussed the matter with Secretary Stimson and General Marshall together. After I had outlined briefly what I wanted, and we had considered the possible value of the information we might gather, we all turned to the big wall map in the Secretary’s office. To my great embarrassment, I was unable to find Hechingen on this map, and both the Secretary and the Chief of Staff were equally unsuccessful. Finally, Mr. Stimson summoned his aide, Colonel William H. Kyle, who succeeded eventually in locating our target at the bottom of the map, not more than two feet above the floor. If a photographer had been present at that time when the four of us were almost on our hands and knees, gazing intently at this point barely off the floor, he might well have caught one of World War II’s more interesting photographs.

A short discussion followed, during which General Marshall asked me how I would ensure the capture of our objectives. I suggested that the necessary American troops, possibly as much as a reinforced corps, should cut diagonally across the advancing French front. Marshall agreed and sent for Major General J. E. Hull, Head of the Operations Division, War Department, General Staff, telling him to issue instructions to General Eisenhower that would take care of our requirements.

[…]

Since the war, I have had occasion to discuss Operation Harborage and other Alsos operations with a number of the officers who were involved. In the course of these discussions, I have made it a point to tell them how much I always appreciated the co-operation given my representatives throughout the European Theater, when the only justification that they had for their apparently outlandish requests were simple memoranda addressed “To Whom It May Concern,” signed by either Secretary Stimson, General Marshall, or in a few cases by Colonel Frank McCarthy, the Secretary of the General Staff, and stating that their mission was of the utmost importance and that the Secretary of War would appreciate any assistance that could be rendered. Invariably, I have been told that it was not a case of kindness on the part of anyone in the European Theater, for these letters were most unusual and they realized that the matters involved must be of paramount importance. But over and above this, I have always felt great pride and pleasure upon hearing from these same commanders that while my officers were far from high-ranking, they were obviously of such ability and so convinced of the importance of their mission and the strength of their backing that they would have accomplished their missions no matter what obstacles stood in their way.

[…]

The WIFO plant was seized quickly and without incident. It was in a terrible condition from repeated bombings, but fortunately the manager had stayed on the job. Hidden in his house was an inventory of the plant’s property, which showed the whereabouts of the missing ore. Approximately eleven hundred tons of it were soon found stored in barrels under open sheds above-ground.

Most of the barrels were either broken or rotten, and it was obvious that the ore would have to be repacked before it could be moved. Complicating the problem was the fact that there were still many German units in the area. Fortune smiled upon Lansdale’s group again when the CIC agents found a barrel factory close at hand. The owner of the plant, who was also the local burgomaster, was soon prevailed upon to round up a sufficient number of laborers and to resume operations. During the next two weeks, with Agent Schriver in charge, and while under intermittent enemy fire, this factory turned out about twenty thousand fruit barrels.

Lansdale, in the meantime, had gone back to SHAEF, where he saw General Smith, and procured the services of a truck company. Trucks were in great demand at this period and the men, all Negroes with one white lieutenant, were exhausted from lack of sleep. They were further handicapped by being far from their normal maintenance bases. Nevertheless, they performed splendidly, and with the use of forced labor to repack and load the ore, the entire tonnage was removed during three days and nights to an airport hangar at Hildes-heim, near Hanover, well behind the Allied lines. A small amount of the ore was lost en route because of the number of truck ditchings caused by the extremely rough roads.

[…]

Observing the ore’s hue and noting that it was escorted by Hambro, a member of a well-known London banking family, many of the British were convinced that it was gold.

From Hanover, a considerable tonnage was moved by air to England. There was too much, however, to carry all of it in this manner, so arrangements were made to move the remainder by rail to Antwerp about two hundred miles away, and thence by ship to England. The precautions for insuring its delivery proved inadequate and somewhere along the line, probably in a switching yard, three cars disappeared, but after an intensive search, Agent Schriver found them, much to our relief.

From England, the ore was sent over to the United States.

[…]

It was becoming apparent that there were two groups in Germany working on the uranium pile, the first under Diebner at Frankfurt and the second under Heisenberg. Heisenberg’s group had been started in 1939 as a co-operative project of the most important physicists in Germany, with headquarters at the Institute of Physics in Berlin. There had been a certain amount of competition between the two groups, and quarrels over who would get materials continued even after all research had been officially consolidated under Gerlach. In Gertner’s opinion, the work done under Diebner was not so good as that over which Heisenberg had supervision.

Having pretty well exhausted its Heidelberg sources, Alsos next turned its attention to the Frankfurt area, where the uranium metal required by the German project had been produced. It found there that the degrees of purity achieved were not particularly high.

Following closely behind the advancing American front, on April 12, Alsos moved in and seized Diebner’s laboratory and offices, which were located in an old schoolhouse. Pash’s people found, however, that the majority of the scientists, together with most of their documents, materials and equipment, had been evacuated on April 8, to carry on their work elsewhere. Nevertheless they picked up some uranium oxide, various pieces of equipment, an extensive physics laboratory and many files. From these last it appeared that Germany’s military interest had been aroused in early 1940 by the experiments of Hahn and Strassman. It had been suggested then that uranium could be used to form an explosive, as well as to serve as a source of energy. Work to this end had been started by Heisen-berg’s group in Berlin, using uranium ore from Joachimsthal, which had been transformed into powdered U-238. This attempt at making a pile, however, was unsuccessful, primarily, I believe, because of the clumsiness of the experimental equipment. Heisenberg’s group continued experiments with their apparatus until about the end of 1941, always with negative results. In spite of their failures, Heisen-berg and von Weizsäxcker calculated that by making a number of modifications to their equipment a self-sustaining pile could be built. The work was transferred to Leipzig, where, in 1942, a pile gave positive results, but was not self-sustaining. This led to the initiation late in 1942 of the so-called large-scale experiments at Berlin Dahlem. Finally, late in 1944, an exponential pile was constructed in Berlin. This, however, was what might be termed purely academic scientific experimentation.

[…]

Something had to be done, and, as usual, Pash did it. He asked for help, and General Harrison gave him operational control of the 1279th Engineer Combat Battalion. With this force he seized Haiger-loch on April 23 and immediately began dismantling the laboratory. Its major feature was the exponential pile, which had been brought there from Berlin in February and concealed in a tunnel under a high cliff. The Alsos detachment was greatly assisted by the arrival of a number of British scientists under the leadership of Sir Charles Hambro, and was able to complete its operations in Haigerloch before the French reached there.

In the meantime, Pash, with one company of the 1279th Engineers, moved on to Hechingen, which he captured on April 24. Efforts to take this town the night before had been strongly resisted, but the final attempt was virtually unopposed. Pash seized a large atomic physics laboratory and a number of the leading German physicists, including von Weizsäxcker and Wirtz.

The next morning he moved into Tailfingen, where they took over a large chemistry laboratory and captured Otto Hahn and Max von Laue. At Stadtilm, Alsos had found signed receipts for all the secret reports and documents that had been sent to the various scientists. But as the men were picked up, one by one, they all announced blandly that everything had been destroyed. Hahn, however, answered promptly, “I have them right here.”

The capture of Hahn was simple. A German on the street, when questioned, pointed the way to an old school building which contained his laboratory. After the school was surrounded by troops, F. A. C. Wardenburg and James Lane, both chemical engineers from du Pont and two of our Alsos scientific personnel, walked in and asked for Hahn. They were shown into his laboratory and started their interrogations. “It was just like a business call on a customer,” was their apt description. By now French Moroccan troops were in the area, yet the mission still had not found the German stores of heavy water and uranium oxide that had been used in the Haigerloch pile. Fortunately, the French were few in number, and the many German units scattered throughout the countryside kept them fully occupied while Alsos was getting its job done.

Skillful questioning of the German scientists by Goudsmit and his associates finally disclosed the hiding place of the heavy water and uranium and, on April 26, the heavy water was removed from the cellar of an old mill near Haigerloch and sent back to Paris. About one and a half tons of small metallic uranium cubes were dug up from a plowed field just outside the town. These, too, were quickly dispatched to Paris. Both water and uranium were then shipped to the U.S., to be disposed of by the Combined Development Trust.

On the twenty-seventh, the German scientists were taken to Heidelberg for further questioning, and later removed to Rheims. As they were in the act of leaving, von Weizsäxcker suddenly blurted out the information necessary to locate the still missing records of the German research programs. They were sealed in a metal drum, which had been deposited in the cesspool in back of von Weizsäxcker’s house.

By the end of April, Alsos was heavily engaged in mopping-up activities. Most of the material we wanted had been secured. A few important scientists — notably Heisenberg — still eluded us. But, generally, our principal concern at this point was to keep information and atomic scientists from falling into the hands of the Russians.

France acquired a bargaining power out of all proportion to anything to which her early patents entitled her

Wednesday, December 17th, 2025

Now It Can Be Told by Leslie M. GrovesGeneral Groves explains (in Now It Can Be Told: The Story of the Manhattan Project) the problem of the French scientists:

The circum­stances that made this possible go back to 1939, when a group of French scientists, working under Joliot’s leadership, had patented a number of inventions that they claimed would provide means for controlling the energy of the uranium atom. They assigned their rights in these patents to the Centre Nationale de la Recherche Scientifique, an agency of the French Government.

One of Joliot’s assistants in this work was Hans von Halban. In June of 1940, when France was collapsing under the German onslaught, von Halban had left for England, taking with him the entire French supply of heavy water, a number of scientific papers, and a verbal commission from Joliot to act for the Centre in attempting to obtain the best possible terms to protect future French interests in the atomic field.

[…]

At the same time, the British employed von Halban and three of his associates from the Centre, eventually, as I have said, assigning them to the laboratories of the Tube Alloys Project in Montreal. By 1944, a number of other Centre scientists had left France to join the Free French Provisional Government in Algiers. The French working in the Montreal laboratories maintained contact with their former colleagues in North Africa and, through them, with their former leader, Joliot, who remained in Paris throughout the German occupation.

[…]

Upon his return to London, von Halban was closely questioned by my agents about his discussions with Joliot and it became obvious, as we had expected, that he had not held the conversation within the bounds of any “barest outline.” Vital information relating to our research had been disclosed—information that had been developed by Americans with American money, and that had been given to the British only in accordance with interchange agreements subsidiary to the Quebec Agreement. It confirmed facts that Joliot might have suspected, but which he otherwise could not have known. This information had always been scrupulously regarded as top secret.

[…]

Having effected a breach in the Quebec Agreement, Joliot proceeded to exploit it. He met with the Chancellor in February, 1945, and made it clear to Sir John that, while France had no immediate desire to press the issue, if she were not eventually admitted to full collaboration with the United States and Britain in the project, she would have to turn to Russia.

Thus, France acquired a bargaining power out of all proportion to anything to which her early patents entitled her. She was enabled to play power politics with our accomplishments and to bring, or threaten to bring, Russia into the picture. The United States was forced to sit quietly by while a large measure of the military security that we had gone to such pains to maintain was endangered and prematurely compromised by the actions of other governments over which we had no control.

In May of 1945, the French Government instructed Joliot to begin work on an atomic energy project. Joliot turned to his colleague, Pierre Auger, who had been working in the Montreal laboratories. Anticipating our concern, the British hastened to assure us that Auger would not participate in the actual work, but would limit his activities strictly to putting the French back on the right line if they made any serious errors. While Dr. Chadwick and I were both confident of Auger’s integrity, we realized that naturally his greatest loyalty was to his own country.

[…]

My sole source of satisfaction in this affair came from a remark made by Joliot to an employee of the United States Embassy in Paris: while the British had always been most cordial to him and had given him much information, he said, he got virtually nothing from the Americans he encountered.

Militant, at any event, after the armistice

Monday, December 15th, 2025

Now It Can Be Told by Leslie M. GrovesItalian scientific research and development, General Groves explains (in Now It Can Be Told: The Story of the Manhattan Project), had been generally disorganized and was almost militant in its resistance to the Fascist state — militant, at any event, after the armistice:

Both Wick and Amaldi had served in the Italian Army and since the surrender had been hiding in Rome. During the war they had engaged in theoretical research principally on isotope separation, neutron, infrared and cosmic rays. They had no direct information about German research in the field of nuclear fission, for they had never been asked to do any work with or for the Germans. They claimed not to understand the significance of heavy water, and they were not aware of any new activity at the Joachimsthal uranium mines in Czechoslovakia.

Wick had made a trip into Germany during June and July of 1942, and had seen and talked at some length with a number of German physicists at that time and, together with Amaldi, had been shown some of the correspondence between various German scientists; thus they were able to supply us with some useful information. They were most co-operative, and what they gave us was the basis for the compilation of brief accounts of the activities and locations of a number of Germans who were of outstanding interest to the MED. Although later investigations in Germany proved that some of the information obtained in Rome was not wholly accurate, in the main it was well worth the trouble we had gone to in collecting it.

[…]

Throughout the European campaign, as far as atomic efforts were concerned, Alsos members had the tremendous advantage of knowing where they were going and whom and what they were seeking. When they landed on the Continent, they had in hand the fruits of Calvert’s labors, in the form of a comprehensive list of intelligence “targets” — the names of key individuals, where they worked and where they lived; and the location of the laboratories, workshops and storage points, and other items of interest to us. At the head of the list was the famous French atomic scientist, Frederic Joliot-Curie (later High Commissioner of Atomic Energy for France), and his equally famous wife, Irene Curie, the daughter of Madame Curie, discoverer of radium.

[…]

On August 25, they reached Paris, at the Porte d’Orleans, ahead of the French troops, and waited there for about half an hour until General LeClerc arrived with his armored division. The General led the triumphal entry, at 8:55 that morning, but tucked into the column, directly behind the first tank was an American jeep containing the first representatives of the U.S. Army: Pash, Calvert and two other Alsos agents.

[…]

There, on the steps of the university, they found Joliot and some of his staff, all wearing FFI arm bands. That evening they celebrated the liberation with Joliot by drinking some champagne he had reserved for the occasion. The American soldier’s staff of life, the K ration, served as the hors d’oeuvres. In keeping with the scientific surroundings, the champagne was drunk from laboratory beakers.

In the course of their conversation with Joliot, the names of two of his former colleagues came up: Hans von Halban, born an Austrian in Leipzig and later naturalized as a French citizen, and Lew Kowarski. Both men had left France for England in June of 1940 and had been working in the British Tube Alloys Project in Canada. Joliot immediately surmised that there was some connection between them, Pash and Calvert, and the uranium problem.

They did not openly tell him at first what they wanted of him. However, after an hour’s conversation, Joliot willingly told them just what they wanted to hear: that it was his sincere belief that the Germans had made very little progress on uranium and they were not remotely close to making an atomic bomb. He said he had refused to perform any war work for the Nazis and had forbidden them to use his laboratories for such purposes. However, after the occupation commenced, he said he did allow two German scientists to move into his laboratory to continue academic work on nuclear physics. He added that he talked with them frequently and clandestinely checked their work at night after the laboratory was closed, thus keeping constant surveillance on their activity. How true this all was we never knew.

[…]

The College of France, which was Joliot’s laboratory, owned a cyclotron, and a number of German scientists of interest to the MED had spent varying lengths of time there operating it. Among them was Professor Erich Schumann, who headed the German Army Research conducted by the Ordnance Department and who, during the war, served as the personal adviser on scientific research to Field Marshal Wilhelm Keitel. Schumann was credited with initiating work on the German uranium project, although by the end of 1942 his responsibilities had been transferred to the Reich’s Research Council.

Another visitor to Joliot’s laboratory was Dr. Kurt Diebner, who in 1939 had served as Schumann’s right-hand man and who had continued nuclear research under the Reich’s Research Council. Then there was Professor Walther Bothe, an outstanding German nuclear experimentalist in the physics laboratory of the Kaiser Wilhelm Institute for Medical Research. Dr. Abraham Essau, who until early 1944 was in charge of physics under the German Ministry of Education in the Reich’s Research Council, had made a number of visits to Paris. Essau had been president of the Ministry’s Bureau of Standards until January, 1944, when he was replaced as Plenipotentiary for Nuclear Physics by Walther Gerlach. There was also Dr. Wolfgang Gertner, an able German scientist who, before the war, had been associated with Ernest Lawrence in the United States. Gertner was an outstanding German authority on cyclotron operations. Joliot’s other visitors had included Dr. Erich Bagge, a member of the Kaiser Wilhelm Institute, who specialized in isotope separation, and Dr. Werner Maurer, an experimental physicist engaged in nuclear research.

Joliot consistently maintained that he had acquiesced in the Germans’ use of the cyclotron with the distinct understanding that its use would not be of direct military assistance to their war effort. There was no independent evidence that this condition was made. There may have been a promise made to him by some of the German scientists, or they may have said that there appeared to be no military possibilities that could result from the use of the cyclotron, but I never found any real proof of Joliot’s contention. Certainly, his subsequent behavior — and I shall come to that shortly — gave us room for doubt.

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The most difficult problem that Calvert’s intelligence group had to tackle was to find out where Hitler was hiding his atomic scientists. They knew, as everyone did, that before the war the Kaiser Wilhelm Institute in Berlin had been a focal point for all atomic physicists and atomic research, not only in Germany, but in all of Europe. It was there that Otto Hahn and Fritz Strassman had carried out their startling experiments. It was also the home of Max Planck, the internationally famous atomic scientist.

As the war drew on, however, and the bombing of Berlin was stepped up, we had learned from both aerial reconnaissance and a Berlin scientist, who got word to us through the Norwegian underground, that research on uranium had been moved, presumably to a safer location, but where he did not know.

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The first information had trickled through in the summer of 1943. It seemed so innocuous that we did not appreciate its full import until much later. It was in the form of a report from an ungraded1 Swiss informant, received by the British Secret Intelligence, stating that a certain Swiss scientist, who was allegedly pro-Nazi, was aiding in the development of an explosive a thousand times more powerful than TNT. His experiments and research were being conducted in the greatest of secrecy in an unused spinning mill in Bisingen, Germany. Inasmuch as Allied Intelligence was receiving hundreds of reports of this nature daily, and coupled with the absence from this one of any telltale words or phrases, such as uranium, atoms, heavy water, cyclotrons or the like, Calvert catalogued this item but did not attach immediate importance to it.

Next, in the fall of 1943, American censorship had intercepted a letter from a prisoner of war in which he mentioned that he was working in a “research laboratory numbered ‘D.’” The letter was postmarked Hechingen, Germany, which is three miles north of Bisingen, in the Black Forest region of Germany, where many secret German projects had been moved. But again the report was so scanty that one could hardly assume that Germany’s atomic research was being carried on in these outwardly sleepy little villages.

It.was not until the spring of 1944 that Calvert received his first solid information. Then the OSS reported from Berne, Switzerland, that a Swiss scientist and professor had said that Dr. Werner Heisenberg, an internationally famous nuclear physicist and one of Germany’s top atomic scientists—if not the top—was living near Hechingen. We knew from other intelligence that Heisenberg was working on the uranium problem. With this new bit of information, Calvert knew that he had found the hiding place of Hitler’s top atomic scientists.

[…]

Calvert’s next big problem was to try to penetrate the area. To do that he would have to get somebody who knew it extremely well. British Intelligence located a vicar living in England who before the war had been Vicar of Bisingen. He was able to pinpoint and identify buildings and factories for us. He also pointed out buildings that had housed spinning mills.

At the same time Calvert sent a very reliable and able OSS agent, Moe Berg, the former catcher of the Washington Senators and Boston Red Sox, and a master of seven foreign languages, into Switzerland to prepare for a surreptitious entry into the Hechin-gen-Bisingen area. While Berg was in Switzerland, he picked up additional information and, passing himself off as a Swiss student, even attended a lecture given by Heisenberg, who had been granted permission to travel outside Germany to deliver this one speech. When I heard of Calvert’s plan for Berg to go into the Hechingen-Bisingen area, I immediately stopped it, realizing that if he were captured, the Nazis might be able to extract far more information about our project than we could ever hope to obtain if he were successful.

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Starting in July, Calvert put the Bisingen-Hechingen area under constant air-photo surveillance. The pilots who flew these missions were never told of the nature of the suspected targets, lest they be interrogated in the event of a crash landing. At first our aerial reconnaissance produced nothing new. Then in the fall of 1944, we had our biggest scare to date. After one aerial sortie it was observed that near the town of Bisingen a number of slave labor camps had been erected with incredible speed. Ground had been broken and a complex of industrial sites had mushroomed within a period of two weeks. Railroad spurs had been constructed; mountains of materials had been moved in; power lines had been erected; and there was every indication that something was being built that commanded the utmost priority. Aerial interpreters, intelligence officers, our own technicians and scientists were all baffled after studying the photographs. Nobody could offer any sensible explanation of this new construction. All we knew was that throughout the past year we had been getting reports that this area was housing Germany’s top atomic scientists. The only thing upon which we could all agree was that whatever the construction was, it was unique. Naturally the first question that came to our minds was whether this was the start of Germany’s “Oak Ridge.” If it was, we did not want to bomb it immediately, since that would only drive the project underground and we would run the risk of not finding it again in time. Yet we could not let construction progress too far, particularly since this was just at the time when it was thought that the Germans might withdraw to the Black Forest and make it a redoubt area. Fortunately our anxiety was short-lived, and the fear of a German atomic plant was dissipated almost as quickly as it had arisen, when some British mining experts recognized that what we had been observing so closely was nothing more than a new form of shale-oil-cracking plant.

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Before the war, when Union Miniere was the world’s leading supplier of uranium and radium, a number of German firms had purchased uranium products for normal peacetime uses, as well as for retrading purposes. The shipments involved in such transactions normally consisted of less than a ton per month of assorted refined materials, but since June, 1940, orders from a number of German companies had increased spectacularly.

A preliminary study conducted by Union Miniere indicated that a quantity of material was still in Belgium. Part of it was ready for shipment, but probably had not yet been removed. When I learned of this, I immediately sent Furman back to Europe with instructions to locate and secure the material. He and Pash conferred with General Bedell Smith, who arranged for the British 21st Army Group to support Alsos in its recovery operations, without revealing to the British the name or purpose of the material being sought. The area where they expected the ore to be was then in the front lines of the British sector and under light sniper fire. Pash and two of his agents hunted for it from September 19 to 25 before they finally found it. The captured ores amounted to sixty-eight tons, which were placed under joint American and British control and removed from Belgium to the United States by way of England.

Information obtained in Belgium led to further investigations in Eindhoven, near Antwerp, where we learned that in May of 1940, nine cars containing approximately seventy-two tons of uranium ores had been shipped out to Le Havre, France, ahead of the German invasion. Apparently, the Germans had seized two of the nine carloads at Le Havre, while the remainder were rerouted to Bordeaux. I instructed Alsos to obtain clearance from Supreme Headquarters, and then to locate this material and secure as much of it as possible. Pash and Calvert concentrated at first on an area in the vicinity of Perigueux, France, and finally in early October expanded their search to include much of southwestern and southern France. They were greatly hindered in their search by the presence of several thousand German troops, who had been cut off south of the Loire River by the Seventh Army. Eventually, they found thirty tons of the missing ore in Toulouse, but the remaining forty-two tons eluded us.

Calvert had by then determined where almost all of the Union Miniere ore in Germany was located and asked permission to make plans to go behind the German lines to get it. I denied his request, for I thought that any such attempt would be doomed to failure, and, what was more important, it would alert the Germans to the fact that we considered the ore to be of such value that we would take great risks to obtain it.

[…]

This operation at Strasbourg was by far the most successful that Alsos had conducted up to that time. The information gained there indicated quite definitely that Hitler had been apprised in 1942 of the possibilities of a nuclear weapon. Nevertheless, all evidence from Strasbourg clearly pointed to the fact that, as of the latter part of 1944, the enemy’s efforts to develop a bomb were still in the experimental stages, and greatly increased our belief that there was little probability of any sudden nuclear surprise from Germany.