Mouse Bred Not To Fear Cats

Friday, December 14th, 2007

I’m glad the photographer managed to catch a shot of this mouse bred not to fear cats before its inevitable demise:

In this undated photo released by Tokyo University’s Department of Biophysics and Biochemistry Graduate School of Science, a genetically modified mouse approaches a cat in Tokyo. Using genetic engineering, scientists at Tokyo University say they have successfully switched off the rodents’ instinct to cower at the smell or presence of cats, showing that fear is genetically hardwired and not leaned through experience, as commonly believed.

Kitten Clones

Friday, December 14th, 2007

Sometimes I wonder if scientists, deep down, want to creep out normal folks. These Korean kitten clones glow in the dark — in the name of science!

This handout photo released in Seoul by the Ministry of Science and Technology shows a combo of cloned cats that have a fluorescence protein gene and glowing under ultraviolet beams. The technology could help develop treatments for human genetic diseases, the developers said.

Is Alzheimer’s a Form of Diabetes?

Friday, December 14th, 2007

Is Alzheimer's a Form of Diabetes?:

Scientists have been searching for the cause of Alzheimer’s disease for more than 100 years, and during that time, theories about why brain cells are destroyed in the course of the illness have come and gone. One of the newer and more unorthodox theories posits that Alzheimer’s may actually be a form of diabetes. Some experts have even taken to calling the brain disease type 3 diabetes, as distinct from the insulin-dependent (type 1) and adult-onset (type 2) varieties of the condition.
[...]
The link between the two diseases was first made about a decade ago when scientists found accumulations of insulin in the brains of Alzheimer’s patients. Doctors have long known that patients with diabetes were two to five times more likely to develop the brain-killing illness, but most Alzheimer’s patients are not diabetic. Insulin creation in the brain is a separate process from insulin production elsewhere in the body, says Brown University’s Dr. Suzanne de la Monte. Thus insulin resistance is separate, too.

The Road Back

Friday, December 14th, 2007

Tim Layden of Sports Illustrated has written about Kevin Everett’s devastating injury and The Road Back from paralysis:

On the first weekend of the 2007 NFL season, Everett fell limply to the Ralph Wilson Stadium turf after making a tackle on the second-half kickoff. He did not get up. The stadium fell silent, an ambulance drove onto the field, and players from both teams formed a prayer circle, the nightmare tableau that can unfold in any football game but is thankfully rare. Everett, a third-year player, had suffered a fracture dislocation in his neck and severe spinal cord damage. He would be the subject of grim prognoses (many victims of his injury, indeed, do not walk again) but also exhaustive and controversial medical care, including the groundbreaking use of a hypothermia treatment that has both encouraged and divided the medical community.

The details:

As Hixon started upfield, he angled toward the middle. Just past the 15-yard line he planted his right foot and prepared to cut outside, to his left. As he made the move, Everett arrived, shoulders squared, his body in an athletic crouch. Just before impact, Everett bent his upper body forward; Hixon dropped his upper body. The players collided violently, the crown of Everett’s helmet meeting the side of Hixon’s. “I’ve seen the play so many times, and it was the timing of it,” says Everett. “I did the same thing I would do every time running down on kickoff team, got low to put my pads under his, and this one time he lowered his helmet.”

Hixon was driven sideways by the blow, staggering to his right, where Aiken finished the tackle. Everett never saw that. “My body went numb instantly,” he says. “I thought he kept going because it felt like he ran smack over me.”

Everett’s body went limp, and he crashed to the artificial turf, flat on his stomach, his head turned to the right. He was motionless except for a momentary twitch of his head and neck as he tried to lift his paralyzed body off the ground with the only muscles in his body still firing.

Fifty yards from Everett, on the Buffalo sideline, stood Andrew Cappuccino, 45, an orthopedic surgeon with specialty training in disorders of the spine and for 13 years a member of the Bills’ staff under the team’s medical director, John Marzo. Eleven days earlier, on Aug. 29, Marzo and head trainer Bud Carpenter had led a 1 1/2-hour spinal cord injury refresher drill at the Bills’ field house in Orchard Park, N.Y. Cappuccino had nearly begged off — “I told Bud, ‘That scenario is never going to happen,’ ” recalls Cappuccino, who’d yet to encounter a spinal cord injury at a Bills game in his time with the team — but Carpenter insisted. Now that drill would form the foundation for the seminal moment in Cappuccino’s career. And in Everett’s life.
[...]
Cappuccino knew there was a flicker of hope. On the field he had applied forceful pressure to Everett’s lower extremities, from his ankles to his groin, and had detected a response that was absent with a sharp sensation such as a pinprick. This told Cappuccino that Everett had suffered an incomplete spinal cord injury, probably meaning that the cord was severely damaged but not severed.

Cappuccino then made two decisions, one that has reverberated through the medical world and one that has gone largely unnoticed but might have been just as critical.

First, he introduced mild hypothermia as a part of Everett’s care. In November 2006, Cappuccino had attended a seminar of the Cervical Spine Research Society and sat in on a talk by Dalton Dietrich, scientific director of The Miami Project to Cure Paralysis. Dietrich devoted the last 10 minutes of his presentation to the potential benefits of induced hypothermia for neuroprotection — the rapid cooling of the body to reduce metabolic demand and to prevent further damage from swelling and other inflammatory mechanisms. It is a controversial treatment that has not been established as a standard of care in spinal cord injuries and is the subject of considerable debate in the field. Partly motivated by that talk, Cappuccino had instructed the EMTs at Bills games to stock their ambulance with three bags of saline solution in a cooler. [...]
Second, Cappuccino instructed Lengel to drive to Millard Fillmore Gates Circle Hospital. Normally a player injured in a Bills game would be taken to Buffalo General, about a mile closer, but Cappuccino knew that Gates has magnetic resonance imaging (MRI) technicians on duty 24 hours a day. This is rare, and with Gates’s in-house CT scanning capability it would enable swift diagnosis of Everett’s injury. The hospital also is the only one in Buffalo with a neurosurgical intensive care unit, under the direction of Dr. Kevin Gibbons, 47.

Everett arrived at the hospital about 35 minutes after the hit. X-rays and CT scans showed a fracture dislocation of Everett’s cervical vertebrae at the C3/C4 level, meaning that one vertebra had slipped out of alignment and was compressing against its adjacent vertebra and the spinal cord in the neck. An MRI showed that Everett’s spinal cord was 70% to 75% compromised, or pinched, by the dislocation.

Cappuccino and Gibbons, assisted by senior neurosurgical resident Ken Snyder, worked to reduce the dislocation. A halo device was screwed into Everett’s skull, and while he remained awake, manual pressure and traction weights were used to realign the vertebrae and remove pressure from the pinched spinal cord. Next would come 4 1/2 hours of surgery to stabilize Everett’s vertebrae and further decompress the spinal cord. Both the reduction and the stabilization surgery are common practices in spinal cord injuries and clearly were vital elements of Everett’s care. [,,,]
Everett was placed on the CoolGard in the predawn hours of Monday, Sept. 10, and within two hours his body had cooled to a temperature of 91.5°. That morning Everett was able to squeeze his thighs against Cappuccino’s hands. “Everybody was stunned,” says Cappuccino, “including me.”
[...]
Twelve days after an injury that could have left him in a wheelchair for life, Everett flew to Houston to begin rehab. Less than a month later he would be walking with assistance.

The Urban Homestead

Wednesday, December 12th, 2007

The Dervaes family’s urban homestead supports four adults, who live and work full time on a 66’ x 132’ city lot (1/5 acre):

The yard has over 350 varieties of edible and useful plants. The homestead’s productive 1/10 acre organic garden now grows over 6,000 pounds (3 tons) of produce annually. This provides fresh vegetables and fruit for the family’s vegetarian diet and a source of income.

The family operates a viable and lucrative home business, Dervaes Gardens, that supplies area restaurants and caterers with salad mix, edible flowers, heirloom variety tomatoes and other in-season vegetables. The income earned from produce sales offsets operating expenses and is invested in appropriate technologies, such as solar panels, energy efficient appliances, and biodiesel processor, to further decrease our homestead’s reliance on the earth’s non-renewable resources.

Over the years, by purchasing energy efficient appliances and using electricity conservatively, the modern homesteaders have cut their energy usage in half. Solar panels have reduced their dependence on electricity by two-thirds and have furthered their goal of energy independence. A solar oven is used to cook food on sunny days. And during the summer of 2005, the family built a cob oven, which is fueled by scraps of wood and twigs to create an energy source for cooking breads, pizzas, desserts, etc.

In 2003, the Dervaeses constructed a biodiesel processor from a discarded hot water heater, which enables them to brew low emissions biodiesel (a renewable, nontoxic, biodegradable replacement for petrol diesel) from used vegetable oil to fuel their diesel Suburban, reducing the vehicle’s air toxins by 90%.

Why pregnant women don’t fall over

Wednesday, December 12th, 2007

Bob Holmes of New Scientist explains why pregnant women don’t fall over:

Women do not tip over during pregnancy because their spines are built differently from men’s – and have been ever since our ancestors began walking upright. The difference allows a pregnant woman to lean backward to counterbalance the weight of her developing fetus.
[...]
They found that the women corrected for their growing imbalance by bending backward in the lower part of their spine. Detailed anatomical measurements showed that the vertebrae of the lower back are more wedge-shaped in women than in men, which makes this bending easier.

The interlocking bony projections that align each vertebra with its neighbours are also relatively larger in women, Whitcome found. This provides added support to prevent the vertebrae from slipping sideways, as they otherwise might because of the sharper bend in the spine.

Chimpanzees, which are mostly quadrupedal, do not show these vertebral adaptations.

However, when the researchers looked at the two known fossil spines of Australopithecus africanus, an ancestral human that lived 2 to 3 million years ago, they saw that one — believed to be a female — did have the wedge-shaped vertebrae and larger interlocking projections seen in modern women, while the other — believed to be a male — did not.

Amazon Ordered to End Free Delivery on Books in France

Wednesday, December 12th, 2007

Zut alors! Amazon Ordered to End Free Delivery on Books in France:

Amazon.com may not offer free delivery on books in France, the high court in Versailles has ruled.

The action, brought in January 2004 by the French Booksellers’ Union (Syndicat de la librairie française), accused Amazon of offering illegal discounts on books and even of selling some books below cost.

The court gave Amazon 10 days to start charging for the delivery of books, which should at least allow the company to maintain the offer through the end-of-year gift-giving season. After that, it must pay a fine of €1,000 (US$1,470) per day that it continues to offer free delivery. It must also pay €100,000 in compensation to the booksellers’ union.

Are You Not Devo? You Are Mutato

Wednesday, December 12th, 2007

LA Weekly has a lengthy article on How Mark Mothersbaugh, an Agent of De-Evolution, wormed his way into America’s subconscious:

The Mutato Muzika building in West Hollywood is painted Day-Glo green and looks like a tipped-over hamster wheel, with mirrored windows as rungs that make the building seem like it’s constantly spinning. Beneath the main-floor recording studio is a big, cluttered circular room. To enter you pass a threshold guarded by a Speed Racer rug, and beyond this threshold is a sight that would give the Klaxons or Datarock a conniption: Korgs and Rolands are scattered on the floor. An Optigon, a rare 1970s-era console organ that uses flimsy discs to play odd, ghostly sounds, sits in a corner. Shelves hold computer monitors, cassette decks and DAT machines; tubular bells are ready to be struck; an EMS polysynthesizer and an electrocomp synthesizer await electricity. An Ondioline keyboard that once belonged to Pink Floyd. Boxes are strewn throughout, but look closer and they’re filled with more memorabilia: a hand-written score for the film Drop Dead Gorgeous; busts of Chairman Mao and JFK.

Mark Mothersbaugh, the soft-spoken but articulate owner of Mutato and founding member of legendary new-wave band Devo, is giving me a tour.

I’m not sure I’m ready to learn The Complete Truth About De-Evolution.

Home Unschooling

Wednesday, December 12th, 2007

David Friedman, son of Milton, has a daughter getting ready for college, and he has decided to write a bit about how he and his wife have chosen to educate their children — the theory and practice of unschooling:

Our approach starts with the fact that I went to a good private school, my wife to a good suburban public school, and both of us remember being bored most of the time; while we learned some things in school, large parts of our education occurred elsewhere, from books, parents, friends, projects.

That certainly sounds familiar.

Some observations about the standard model of K-12 schooling:

1. That model implicitly assumes that, out of the enormous body of human knowledge, there is some subset that everyone should study and that is large enough to fill most of thirteen years of schooling. That assumption is clearly false. Being able to read and do arithmetic is important for almost everyone. Beyond that, it is hard to think of any particular subject which there is a good reason for everyone to study, easy to think of many subjects outside the standard curriculum which there are good reasons for some people to study.

2. It implicitly assumes that the main way in which one should learn is by having someone else tell you what you are going to study this week, what you should learn about it, and your then doing so.

As some evidence of the failure of that model, consider my wife’s experience teaching a geology lab for non-majors at VPI, probably the second best public university in the state. A large minority of the students did not know that the volume of a rectangular solid — a hypothetical ore body — was the length times the height times the depth. Given that they were at VPI they must have mostly been from the top quarter or so of high school graduates in Virginia; I expect practically all of them had spent at least a year each studying algebra and geometry.
[...]
3. A related assumption is that you learn about a subject by having someone else decide what is true and then feed it to you. That is a very dangerous policy in the real world and not entirely safe even in school — many of us remember examples of false information presented to us by teachers or textbooks as true. A better policy is to go out looking for information and assembling it yourself.
[...]
We concluded that the proper approach for our children was unschooling, which I like to describe as throwing books at them and seeing which ones stick.

More on practice:

Betty remembered having liked and learned from How To Lie With Statistics — actually about how not to be fooled by statistical arguments — so we got a copy and both kids liked it. Our son likes D&D and other games with dice rolling, so was interested in learning how to figure out the probability of getting various results. It turned out that the same author and illustrator had produced a book on simple probability theory — How to Take a Chance — so we got it and he read it multiple times. The result was a ten year old (I’m guessing — we didn’t keep records) who could calculate the probability of rolling 6 or under with three six-sided dice. For the last few years his hobby has been creating games. At the Los Angeles World Science Fiction Convention he had an interesting and productive conversation with Steve Jackson of Steve Jackson games concerning a game Bill had invented; currently one of his ambitions is to get a board game commercially published by age sixteen.

I am fond of evolutionary biology, so recommended The Selfish Gene to my daughter. She liked it, found the approach intriguing, and read other things. Currently she is waiting for me to finish The Moral Animal so that we can discuss it. She also likes economics. At this point she has audited four of the classes I teach at the law school, following them at the level of the better students. She also has her own footnote in one of my articles, crediting her with a significant point she contributed to it.

Both kids spend a lot of time online. We discovered that Bill had taught himself to type when the family was playing a networked game on the home network — Diablo or Diablo II — and misspelled words started appearing on our screen. He needed to type because he played games online and wanted to be able to communicate. Later he wanted to learn how to spell so that he wouldn’t look stupid to the people he was communicating with. His sister spends a good deal of time on World of Warcraft, some of it writing up battle reports and other essays to be posted on suitable web sites. She too wants her writing to look good and so consults, usually with her mother, on how best to say things.

I am fond of poetry and know quite a lot of it. When our daughter was little, I used it to put her to sleep. Sometime thereafter we were driving somewhere at night and heard a small voice from the back seat reciting “Lars Porsena of Clusium, by the nine gods he swore” — the opening lines of “Horatius at the Bridge” — in a a two year old’s lisp. She now knows quite a lot more poetry. When I put my son to bed — my wife and I take turns — we generally talk for a while, then he asks for some poems.

Fast Times at Ridgemont High

Wednesday, December 12th, 2007

I recently had the opportunity to introduce a couple friends to the teen-classic, Fast Times at Ridgemont High, and I realized just how hard it is to convey the experience of seeing Fast Times back when it was new and fresh, because it’s the source of so many now-cliché bits.

Thinly veiled versions of Sean Penn’s surfer-stoner character, Spicoli, ended up everywhere in the late 80s — even the Teenage Mutant Ninja Turtles borrowed his style — but it was new in 1983.

Also, at the time, this was legitimately shocking:

Jeff Spicoli: Hey, you’re ripping my card.
Mr. Hand: Yes.
Jeff Spicoli: Hey, bud, what’s your problem?
Mr. Hand: No problem at all. I think you know where the front office is.
Jeff Spicoli: You dick!

In this era of Superbad, that’s nothing.

Watching the movie also convinced me to look up a few things.

I can’t say I knew Vincent Schiavelli by name, but I certainly recognized him from any number of roles.

I didn’t realize that his distinctive appearance came as a result of Marfan syndrome.

Wind-Powered Rotor Ships Were Maritime Breakthrough of the 20s

Wednesday, December 12th, 2007

Wind-powered rotor ships were the maritime breakthrough of the 20s — according to the March 1925 issue of Popular Mechanics:

With a proven record of supplying clean, natural energy to mariners ever since they first took sails to sea, wind power is an attractive — if inconsistent — alternative to diesel engines, which consume gallons of oil. In March 1925, Popular Mechanics featured an innovation called the “rotor ship,” invented by German engineer Anton Flettner. The vessel was hailed as “the first new development in sailing ships since the earliest navigators discovered they could utilize the wind’s power.” Buckau, the first of the rotor ships, featured two hollow towers of steel, 10 ft. in diameter and 65 ft. tall, mounted on pivots powered by 9-hp motors. The towers utilized the Magnus effect—wind currents striking a rotating cylinder exert a force approximately at right angles to the direction of the wind. After an initial jumpstart from the motors, the cylinder’s motion caused the ship to advance, PM reported. Its designers claimed the vessel outran other sailing ships as well as freight steamers.

More than 80 years after the rotor ship’s birth and demise — engines proved most practical at the time — engineers are searching for modern methods of harnessing the winds to propel cargo ships. The Association for Innovative Propulsion Concepts is now testing the SkySail parafoil, a type of kite that supplements the engines of a cargo ship — and that’s caught PM’s attention once again.

I’ve mentioned kite-like sails before. Now Popular Mechanics has an entire article on how kite power could finally pull global shipping to the green side:

To operate, the captain would first raise a telescoping mast to launch the kite, which waits for use folded like an accordion. Twenty minutes later, the kite would be high enough to unfurl completely. The entire process is automated: Computer-controlled steering compensates for wind direction, speed and bearing. Steering the sail is akin to steering a paraglider or parachute — the “autopilot” pod flying just under the kite shortens one side to dump wind and turn. A piloting program using weather updates and a schedule could help captains plan the optimum route, officials with the company that designed the system say.

During 27 test cruises of the research ship Beaufort, owned by the Association for Innovative Propulsion Concepts, a sail of 80 square meters produced pulling power of 7 tons at wind forces up to 25 mph — strong enough to form whitecaps. Towing kites of twice the size could be employed on the Beaufort, which, according to the researchers, could save up to 2400 liters of marine gas oil per day.

FightMetric Analysis of Huerta-Guida at TUF 6 Finales

Tuesday, December 11th, 2007

The sport of MMA (Mixed Martial Arts) is maturing, as this thorough FightMetric Analysis of Huerta-Guida at the TUF 6 Finales demonstrates.

In the first two rounds, Guida dominated, taking the fight to the ground almost at will and pounding away from his superior position:

“Though he is often characterized as a wild striker, Guida actually landed more than half of his strikes, connecting on 55% of strikes on the feet.”

“Able to take Huerta down almost at will, Guida pounded on Huerta with rights and lefts from the guard and with powerful knees to the body from side control.”

“The first thing that stands out is that Guida succeeded on all of his takedown attempts, including one slam. This is particularly impressive given that the five non-slam takedowns all came on shots from the outside, which have a historically lower success rate than clinch takedowns.”

Fascism on Pearl Harbor Day

Monday, December 10th, 2007

I did not realize that Jerry Pournelle (Lucifer’s Hammer) wrote a dissertation on how the political spectrum has more than one dimension, and the old left-right dichotomy doesn’t really work:

The notion of a “left” and a “right” has been with us a long time. It originated in the seating arrangement of the French National Assembly during their revolution. The delegates marched into the Hall of Machines by traditional precedence, with the aristocrats and clergy entering first, then the wealthier bourgeois, and so on, with the aristocracy seated on the Speaker’s right. Since the desire for radical change was pretty well inversely proportionate to wealth, there really was, for a short time, a legitimate political spectrum running from right to left, and the concept of left and right made sense.

Within a year it was invalidated by events. New alliances were formed. Those who wanted no revolutionary changes at all were expelled (or executed). There came a new alignment called “The Mountain” (from their habit of sitting together in the higher tiers of seats). Even for 18th Century France the “left-right” model ceased to have any theoretical validity.

Yet it is with us yet; and it produces political absurdities.

He chooses two political axes: Attitude toward the State and Attitude toward planned social progress.

He returns to this idea while discussing Fascism on Pearl Harbor Day:

Most people today believe that Fascism is a “right wing” movement. I say “right wing” in quotes because I don’t believe the left-right political spectrum is a very useful tool for political analysis, but that’s another story already told; but to the extent that “left” and “right” have meaning, Fascism, a movement started by the Syndicalist-Socialist labor leader Benito Mussolini, certainly was a “left wing” movement. The successful deception to put it on the “right” was a tactic of the Communists, who tried to build an “anti-Fascist” coalition that would attract respectable people like J. Robert Oppenheimer. Of course the Communists were perfectly willing to make common cause with the Fascists in opposing the Socialists, but that’s another matter.

The theory of Fascism, to the extent that it has a self-consistent political philosophy, accepts the Marxist theory of history as a series of class struggles; but whereas Communism seeks to end class warfare, Fascism believes social classes are inevitable. Mussolini was undoubtedly influenced in this belief by the brilliant work of Vilfredo Pareto, whose work demonstrated that power is always distributed unevenly, there will always be elites, and attempts to destroy class structures only replace one kind of social class with another. (The history of Communist societies and the nomenklatura are instances of successful predictions of Pareto’s theories.)

Since social classes are inevitable, but class warfare cripples the state, the solution to the problem is for the State to stand above the social classes and force them to work together, preferably in equity and fair play. Fair play or no, though, the important thing is to make the classes cease their warfare and stop cancelling each other out, so that there can be social progress and national greatness. Hitler was Mussolini’s disciple from the 1920s until the Austrian Anschluss. For a demonstration of the “left wing” nature of his thought, get a copy of Leni Riefenstahl’s brilliant propaganda film The Triumph of the Will. In particular see the sequence in which thousands of laborers do a manual of arms with shovels, as the voiceover speaks about the relationship of “the classes and the masses.”

Italian Fascism and its copiers including Francisco Franco’s Phalange brought representatives of all social classes and institutions into the government, and in Italy the Grand Council of Fasces was the supreme legislative and policy body in the Kingdom; when in 1943 the Council voted no confidence in Mussolini as Duce, the King dismissed him.

Fascism had supporters in other countries. Franklin Delano Roosevelt resorted to a number of Fascist devices, including the “Blue Eagle” NRA; traces of this syndicalism remain in regulations governing the product of citrus fruit and milk to this day. Huey Long of Louisiana, himself sympathetic to the fascist theory of history and government, pointed out the fascist elements in Roosevelt’s programs, and famously said that when Fascism came to the United States it would be in disguise.

The great conflicts between Fascism and Communism during the 1930s were not due to any great theoretical difference between the two philosophies; instead it was a power struggle pure and simple, each convinced that the other had stolen the other’s clothes.

This is relevant to today’s news in that the Bush plan for ending the mortgage crisis could have come right out of Mussolini’s play book. It requires the loan companies to cooperate and devise rules, all reminiscent of the NRA. Note that the Democrats are quite in favor of the plan, only they want it to go farther and be under more government (bureaucratic) control. Neither has any trust in the free market.

[...]

The Fascist view, that government needs to step in and ameliorate class warfare by forcing the classes to work together, is not altogether a bad thing. It is certainly the case that class warfare can cripple a state and hurts everyone.

The problem with Fascism is the general problem of overly powerful government: instead of learning about economics and the forces of the market place, or inventing something new, or even working hard and saving money, the key to success is manipulation of bureaucracies. That can be through nepotism — my cousin Takagora in personnel will ship you to Point Barrow if you don’t promote me — or through demagoguery, through intimidation or persuasion; but manipulation of the bureaucracies becomes the key to great success. If you read fiction written in India about conditions under the Permit Raj after Indian Independence, or examine life in Pakistan today, you will find illustrative examples. And of course for the very rich and powerful there’s also direct influence over the government at the policy level.

We’re going to intervene in the housing finance market. Given the stakes, there’s no chance it will be ignored.

Huey Long would be pleased.

How board game helped free POWs

Sunday, December 9th, 2007

Brian McMahon explains how a board game helped free POWs from Nazi prison camps:

Along with the standard thimble, car, and Scotty dog, the POW version [of Monopoly] included additional “playing” pieces, such as a metal file, a magnetic compass, and of course, a regional silk escape map, complete with marked safe-houses along the way — all neatly concealed in the game’s box.

Even better, some of the Monopoly money was real. Actual German, Italian, and French currency was placed underneath the play money for escapees to use for bribes.

Also, because of its collaboration with the International Red Cross, Waddington could track which sets would be delivered to which camps, meaning escape maps specific to the area could be hidden in each game set. Allied soldiers and pilots headed to the front lines were told to look for the special edition game if they were captured. The identifying mark to check for? A red dot in the corner of the Free Parking space.

Antibacterial chemical disrupts hormone activities

Sunday, December 9th, 2007

A popular antibacterial chemical disrupts hormone activities — by increasing hormone effects:

This is the first endocrine study to investigate the hormone effects of the antibacterial compound triclocarban (also known as TCC or 3,4,4′-trichlorocarbanilide), which is widely used in household and personal care products including bar soaps, body washes, cleansing lotions, wipes and detergents. Triclocarban-containing products have been marketed broadly in the United States and Europe for more than 45 years; an estimated 1 million pounds of triclocarban are imported annually for the U.S. market.

The researchers found two key effects: In human cells in the laboratory, triclocarban increased gene expression that is normally regulated by testosterone. And when male rats were fed triclocarban, testosterone-dependent organs such as the prostate gland grew abnormally large.

Also, the authors said their discovery that triclocarban increased hormone effects was new. All previous studies of endocrine disruptors had found that they generally act by blocking or decreasing hormone effects.