This Is Your (Father’s) Brain on Drugs

Monday, September 17th, 2007

This Is Your (Father’s) Brain on Drugs:

What experts label “adolescent risk taking” is really baby boomer risk taking. It’s true that 30 years ago, the riskiest age group for violent death was 15 to 24. But those same boomers continue to suffer high rates of addiction and other ills throughout middle age, while later generations of teenagers are better behaved. Today, the age group most at risk for violent death is 40 to 49, including illegal-drug death rates five times higher than for teenagers.

Full fat milk makes you thinner

Monday, September 17th, 2007

Full fat milk makes you thinner:

Full fat dairy products are more likely to keep you slim than comparable low fat foods. That’s the apparently topsy-turvy conclusion of a new Swedish study, which shows that the fat encourages calcium uptake.

Researchers at Stockholm’s Karolinska Institute now reckon that daily consumption of full fat dairy products will lead to a reduction of obesity, reported Svenska Dagbladet.

he startling result was based on interviews with almost 20,000 women whose dietary habits have been tracked since 1987.

When the study began, the women had an average body mass index (BMI) of 23.7. Ten years later, the women who had regularly consumed full fat milk or cheese had a lower BMI than the rest of the group.

A glass of full fat milk every day will, according to the researchers, result in 15 percent less weight gain. But full fat cheese was an even more effective slimming product: one portion a day resulted in 30 percent less weight gain.

“The surprising conclusion was that increased consumption of cheese meant that overweight women lost weight,” said Alicja Wolk, professor at Karolinska Institute, to Svenska Dagbladet.

Female Giant Panda Cub

Saturday, September 15th, 2007

Today’s dose of cute come from this Female Giant Panda Cub:

San Diego Zoo veterinarians confirmed Thursday, Sept. 13, 2007, in San Diego, that the 4-pound giant panda cub is a girl. Born Aug. 3, the cub is the third female panda born at the San Diego Zoo’s Giant Panda Research Station since 1999. A male cub was born in 2003. Following Chinese tradition, she will receive her name after she is 100 days old. The cub and her mother Bai Yun can be seen 24-hours-a-day through the Zoo’s Panda Cam at www.sandiegozoo.org.

Sick? Lonely? Genes tell the tale

Saturday, September 15th, 2007

Sick? Lonely? Genes tell the tale — sort of:

John Cacioppo, a psychology professor at the University of Chicago, has been studying the health effects of loneliness for years in a group of people who have allowed him to delve in-depth into their social lives and health.

Cole and Cacioppo’s team studied 14 of these volunteers — six who scored in the top 15 percent of an accepted scale of loneliness.

“These are people who said for four years straight ‘there’s really nobody that I feel that close to’,” Cole said.

The other eight were the least lonely of the group.

Cole’s team took blood and studied the gene activity of their immune system cells — the white blood cells that protect from invaders such as viruses and bacteria.

All 22,000 human genes were studied and compared, and 209 stood out in the loneliest people.

“These 200 genes weren’t sort of a random mishmash of genes. They were part of a highly suspicious conspiracy of genes. A big fraction of them seemed to be involved in the basic immune response to tissue damage,” Cole said.

Others were involved in the production of antibodies — the tag the body uses to mark microbes or damaged cells for removal, Cole said.

The findings suggest that the loneliest people had unhealthy levels of chronic inflammation, which has been associated with heart and artery disease, arthritis, Alzheimer’s and other ills.

The next step is to see if this might be treated, Cole said. “This is a biological target for intervention,” he said. “Maybe we can give these people aspirin.” Aspirin, an anti-inflammatory drug, is also a blood thinner taken regularly by many people to prevent heart attacks and stroke.

The report is available freely online in the journal Genome Biology at http://genomebiology.com/.

The Mercury Theatre on the Air

Friday, September 14th, 2007

Fans of War of the Worlds should enjoy The Mercury Theatre on the Air:

The finest radio drama of the 1930’s was The Mercury Theatre on the Air, a show featuring the acclaimed New York drama company founded by Orson Welles and John Houseman. In its brief run, it featured an impressive array of talents, including Agnes Moorehead, Bernard Herrmann, and George Coulouris. The show is famous for its notorious War of the Worlds broadcast, but the other shows in the series are relatively unknown. This site has many of the surviving shows, and will eventually have all of them.

The show first broadcast on CBS and CBC in July 1938. It ran without a sponsor until December of that year, when it was picked up by Campbell’s Soup and renamed The Campbell Playhouse. All of the surviving Mercury Theatre shows are available from this page in RealAudio format (some are also in MP3 format). There are several Campbell Playhouse episodes available here as well, in both RealAudio and MP3 formats; the rest are being added gradually.

War of the Worlds eComic

Friday, September 14th, 2007



The folks at Dark Horse have published a War of the Worlds eComic online, and it looks capital!



(Hat tip to Drawn!)

Haystack Syndrome 4

Thursday, September 13th, 2007

In The Haystack Syndrome, which I thought I was done discussing, Goldratt presents a production and marketing problem with a less-than-intuitive solution:



If you read much Goldratt, you know he’s always talking about constraints, which is a clue to how to solve the problem — it’s a thinly disguised linear programming problem.

In this day and age, solving linear programming problems is remarkably easy — if you know how to formulate the problem for Excel’s Solver add-in. This Google spreadsheet lays out the basic problem, but Google hasn’t built a Solver analog into it’s spreadsheet tool just yet.

Mountain Lion Warning Sign

Thursday, September 13th, 2007



If you encounter a mountain lion:

  • Face lion, back away slowly.
  • Be large, shout.
  • Keep children close. Pick up children without bending.
  • If attacked, fight back.

How To Make Money With Mixed Martial Arts Gyms

Thursday, September 13th, 2007

How To Make Money With Mixed Martial Arts Gyms:

Have you ever heard about Karen Santaniello or her husband, James. James was in construction and Karen in real estate when they jumped into the growing MMA mix. In 2004, James’ construction company was about to tear down the studio where he trained in jiujitsu. The Brazilian jiujitsu instructor Juliano Prado, 34, and Colin Oyama, a 34-year-old MMA instructor at a neighboring gym, proposed a partnership with the Santaniellos to open a new facility. Within three months, the four partners opened No Limits, a 15,000-square-foot MMA gym in Irvine, California.

By the end of 2006, No Limits had outgrown its facility, moved to a 26,000-square-foot building and taken on another partner, Ben Kane. Today, No Limits has roughly 1,000 members, projects 2007 sales of $1.8 million and holds claim to the largest MMA facility in North America.

“We don’t just stick clients on a treadmill,” says Karen. “They are being taught by instructors who are very capable.” Capable, indeed–their instructors have trained MMA stars Randy Couture, Dan Henderson and Tito Ortiz, as well as Olympic gold medal-winning wrestler Rulon Gardner.

Even entrepreneurs without a direct MMA product or service are tapping the market. Todd Greene, founder of HeadBlade, a Culver City, California-based business that makes head-shaving razors and other head-care products, began advertising on UFC ring posts in 2004. At the time, his business was making less than $1 million. “I knew this was going to be a mainstream sport,” says Greene, 40. Today, HeadBlade continues to advertise with the UFC and other MMA organizations and has seen revenue spike to almost $10 million.

How Tim Leatherman outdid the Swiss Army knife

Thursday, September 13th, 2007

As a fan of both Leatherman multi-tools and entrepreneurialism, I enjoyed the story of How Tim Leatherman outdid the Swiss Army knife:

My wife and I decided to travel abroad in 1975. We were young-it was one of those budget trips, and we bought an old Fiat in Amsterdam for $300. I was carrying a Boy Scout-type knife and used it for everything, from slicing bread to making adjustments to the car. But I kept wishing I had a pair of pliers! During the trip — it lasted almost nine months — I had a piece of paper in my pocket where I listed ideas for new products, things I might work on back in the U.S. It was in a hotel room in Tehran that I started sketching a pocketknife that contained pliers.

Once we got back to Portland, I asked my wife if I could build it — just one for me. I told her it would only take a month, and she got a job to support us. I set up shop in the garage and picked up a file and a hacksaw. (I have a degree in mechanical engineering but knew nothing about machining.) My brother-in-law was a machinist, and what he didn’t teach me about metalworking, I had to figure out myself. My month turned into three years. I learned that I’m not a very good inventor. I don’t have much foresight. You know Marconi, who built some of the first radios? I’ve heard that before he picked up a pencil, he had the entire model envisioned in his mind. I’m not that way. It took a few months just to visualize each part of the knife.

The first concept was a knife with a pair of regular pliers, and then a separate needle nose would swing over and be driven by the pliers. Then I got really ambitious and decided to add a feature that would lock the pliers, so that once I’d grab onto something, they would stay clamped. I wanted to put in a hacksaw, but they wear out pretty fast. I even tried to put in a can opener, a flat screwdriver, a leather punch, a pair of scissors, and a Phillips screwdriver. Eventually I ended up with two prototypes.

At that point I filed for a patent. I was hoping for an easy way out, that someone would pay me a million dollars for the patent rights. I thought my most likely prospects would be knife companies, so I brought my prototype to Gerber, a Portland, Ore., knife business. They looked it over and said, “This isn’t a knife, it’s a tool. We’re not in the tool business.” I still thought it was a knife, so I went to the major knife companies, but they all said no. I eventually got the message, and decided that if it’s not a knife, it’s a tool. I visited several tool companies, and they all said, “This isn’t a tool, it’s a gadget. Gadgets don’t sell.”

It took eight years before the tool took off. Read the whole story.

The trapped bottom billion

Thursday, September 13th, 2007

The trapped bottom billion cites an “outstanding review” of Paul Collier’s The Bottom Billion:

The Nobel laureate Robert Solow once wrote that economists are intellectual sanitation workers: their key contribution is to consign bad ideas to the trash. Collier seizes this role vigorously, launching a devastating bombardment on people and organizations that, benevolently or malevolently, reinforce the traps: Togo’s president, Faure Gnassingbé, would make his greatest contribution to development “by dying.” Nongovernmental organizations (NGOs) such as Christian Aid inhabit a “satisfyingly simple … fantasy world” and exercise “power without responsibility.” Advocates of “fair trade” effectively work to ensure that poor people “get charity as long as they stay producing the crops that have locked them into poverty.” Campaigners for trade barriers to protect poor countries from globalisation are “idiots,” and rich-country bankers who hide and invest kleptocrats’ assets are “pimps.” And aid workers furtively dodge the bottom billion because most find life unglamorous in outposts such as Bangui and Vientiane.

Don’t underestimate the challenge:

[W]e are play-acting if we underestimate the magnitude of the challenge by peddling “solutions” of any sort. The combined GDP of the 58 countries of the bottom billion is about $350 billion per year — smaller than the GDP of metropolitan Chicago. It is not at all clear that every slice of such a tiny pie is viable as a future rich country. And even if we could somehow spark 2% growth across the bottom-billion countries (an epochal achievement in a zero-growth area), two generations from now their collective income per capita would hover around $3 a day — about the level of Honduras and Sri Lanka today.

Here’s where it gets interesting:

Here Mr Clemens seems to gesture toward perhaps the biggest and most controversial idea in development circles. Why would anyone with a robust sense of reality simply assume that each national jurisdiction contains the seeds of a viable economy? If we insist on thinking of development as a matter of national growth, we may well consign most of the bottom billion, and their children and their grandchildren, to unrelenting poverty trapped within their UN-recognised national prisons. Our real moral concern should not be the Central African Republic, but its unfortunate denizens. The best thing for their prospects may simply be to get out — to leave for a place where growth has already commenced. The West’s many attempts to jumpstart growth where the world’s poorest already reside has yet to work. So why does the international community insist on betting the poor’s lives on the gamble that it will, finally, some day?

Making Cheaper Solar Cells

Thursday, September 13th, 2007

Heliovolt is Making Cheaper Solar Cells with the $77 million in venture capital it has received:

Heliovolt is one of several startups developing a type of thin-film solar cell that converts light into electricity with a micrometers-thick layer of a copper-indium-gallium selenide (CIGS) semiconductor. Thin-film solar cells are attractive because they could produce electricity cheaper than conventional silicon solar cells. Although thin-film cells produce less electricity per square meter than conventional silicon solar cells do, they make up for this by using orders of magnitude less active material per square meter. This can result in significant savings. For example, generating one watt of electricity requires about 80 cents’ worth of silicon, but it only requires a penny’s worth of a semiconductor used in a thin-film cell, says John Benner, who manages electronic materials for photovoltaics research at the National Renewable Energy Laboratory (NREL), in Golden, CO. (Heliovolt is working with NREL to further develop its cells.)

Nurture strikes back

Thursday, September 13th, 2007

Nurture strikes back:

Writing in Psychological Science, a team led by Ian Spence of the University of Toronto describes a test performed on people’s ability to spot unusual objects that appear in their field of vision. Success at spatial tasks like this often differs between the sexes (men are better at remembering and locating general landmarks; women are better at remembering and locating food), so the researchers were not surprised to discover a discrepancy between the two. The test asked people to identify an “odd man out” object in a briefly displayed field of two dozen otherwise identical objects. Men had a 68% success rate. Women had a 55% success rate.

Had they left it at that, Dr Spence and his colleagues might have concluded that they had uncovered yet another evolved difference between the sexes, come up with a “Just So” story to explain it in terms of division of labour on the African savannah, and moved on. However, they did not leave it at that. Instead, they asked some of their volunteers to spend ten hours playing an action-packed, shoot-’em-up video game, called “Medal of Honour: Pacific Assault”. As a control, other volunteers were asked to play a decidedly non-action-packed puzzle game, called “Ballance”, for a similar time. Both sets were then asked to do the odd-man-out test again.

Among the Ballancers, there was no change in the ability to pick out the unusual. Among those who had played “Medal of Honour”, both sexes improved their performances.

That is not surprising, given the different natures of the games. However, the improvement in the women was greater than the improvement in the men—so much so that there was no longer a significant difference between the two. Moreover, that absence of difference was long-lived. When the volunteers were tested again after five months, both the improvement and the lack of difference between the sexes remained. Though it is too early to be sure, it looks likely that the change in spatial acuity—and the abolition of any sex difference in that acuity—induced by playing “Medal of Honour” is permanent.

That has several implications. One is that playing violent computer games can have beneficial effects. Another is that the games might provide a way of rapidly improving spatial ability in people such as drivers and soldiers. And a third is that although genes are important, upbringing matters, too.

In this instance, exactly which bit of upbringing remains unclear. Perhaps it has to do with the different games that boys and girls play. But without further research, that suggestion is as much of a “Just So” story as those tales from the savannah.

Bottle makes dirty water drinkable

Thursday, September 13th, 2007

Bottle makes dirty water drinkable:

The way fresh water is supplied to disaster-hit regions could be revolutionised after an Ipswich-based businessman invented a £190 bottle that makes foul-smelling water drinkable in seconds.

Michael Pritchard hopes that the bottle could be a life-saver for refugees in disaster regions where access to clean drinking water is vital.

However, the military are already latching on to his idea. Four hours after Mr Pritchard launched his new “Life Saver” bottle at the DESI defence show in London yesterday, he sold out his entire 1,000 stock. “I am bowled over,” he said.

Military chiefs are excited because the bottles, which can distill either 4,000 litres or 6,000 litres without changing the filter, will have huge benefits for soldiers who hate drinking iodine-flavoured water.

In July a protype of the bottle was voted “Best Technological Development” at the Soldier Technology conference.

Mr Pritchard, who runs a water treatment business in Ipswich, was inspired after watching coverage of the tsunami in south-east Asia on Boxing Day 2004 and of Hurricane Katrina in Louisiana the following year.

He was amazed to see refugees waiting for days to get any fresh water.

He said: “Something had to be done. It took me a little while and some very frustrating prototypes but eventually I did it.”

Conventional filters can cut out bacteria measuring more than 200 nanometres but not viruses, which typically are 25 nanometres long.

Mr Pritchard’s bottle can clean up any water — including faecal matter — using a filter that cuts out anything longer than 15 nanometres, which means that viruses can be filtered out without the use of chemicals.

Return of the Easy Rider

Thursday, September 13th, 2007

Return of the Easy Rider looks at Shimano’s efforts to get more people on bicycles:

The new “Coasting” bikes are a daring attempt by the bike industry to get some of the 161 million Americans who don’t ride back in the saddle. Bike sales in the U.S. have been flat for nearly a decade, hovering between $5.5 billion and $5.9 billion since 1999, according to the National Sporting Goods Assn. Worse, the number of people riding bikes is falling. According to the sporting goods group, 35.6 million Americans over 7 rode a bike at least six times last year, down from 43.1 million in 2005 and 53.3 million in 1996. “We lost a lot more cyclists than we thought,” says David Lawrence, senior manager for product development and marketing at Shimano America Corp., the Japanese bike component manufacturer behind the Coasting gambit. “It wasn’t sustainable.”

The bike industry was blinded by a blip in sales of high-margin, top-end road bikes after Lance Armstrong’s remarkable string of seven Tour de France victories. Sales of those expensive, high-tech marvels of modern engineering stabilized revenues, even as unit sales slid.

And that was Shimano’s motivation to come up with the Coasting concept and sell the idea to bikemakers such as Trek and Giant. For Shimano, Coasting is not just another new product. The company is the Microsoft of the bike industry. Manufacturers install Shimano’s components — gears, derailleurs, crank arms, and the like — on the vast majority of bikes produced. As the bike business goes, so goes Shimano.
[...]
In the process, Shimano learned why people stopped riding. It wasn’t so much that they were out of shape, or too busy or lazy. It was because cycling had become intimidating, something for hard-core athletes who love all the technical minutiae. “Everything had changed in bicycling,” says Shimano’s Lawrence. “It had gone from fun to being a sport, and no one had noticed.”

For boomers, bikes changed from the 10-speed rides on steel frame bikes to 30-speed carbon fiber and titanium machines. Costs rose from a few hundred dollars to thousands. Handlebars, pedals, tires, even seats came in so many varieties that consumers got overwhelmed. And bike shops, filled with workers who fawned over gear, had little time for customers interested in just plain bikes. Yet there was hope for Shimano. “Everyone we talked to, as soon as we talked about bikes, a smile came to their face,” Webster says. And that nostalgia gave Shimano an opening.

With IDEO, Shimano developed a concept for a new bike that had a familiar look and was easy and fun to ride. In fact, riders of Coasting bikes never have to shift gears. To keep things simple, the bike uses Shimano’s automatic shifting technology. There’s a tiny computer on the seat post or tucked under the bottom bracket that triggers a gear change when riders hit 7 mph, and again at 11 mph. The processor is powered by the rotation of the front wheel. In addition to the back-pedaling Coasting brakes, some bikes come with puncture-resistant tires and a chain guard to keep the grease off cyclists’ pants.
[...]
And Shimano also moved to improve the shopping experience. Shimano put bike industry executives who have direct contact with bike-shop staff through empathy training. To understand how uncomfortable many customers feel in bikes stores, the male managers were sent to buy cosmetics at Sephora.