Scorpions Produce Two Types of Venom

Tuesday, January 21st, 2003

According to Scorpions Produce Two Types of Venom, scorpions produce a biologically “cheap” prevenom and a separate, deadly, “last resort” venom:

Scorpions don’t bother to waste venom killing a victim if they don’t have to. Instead they use a prevenom that causes extreme pain, resorting to the deadlier version only when necessary, researchers have discovered.

A team led by entomologist Bruce D. Hammock of the University of California, Davis, was researching the possibility of an anti-venom for scorpions when they discovered that the stinging creatures produced two kinds of venom.

Although I find “anti-venom” perfectly intuitive — that’s what I would’ve called it — the “correct” term is “antivenin” — for reasons unknown. (Similarly, inflammation of a tendon is not “tendonitis” but “tendinitis”. Sigh.)

When first confronted by a threat the scorpion produces a clear liquid on its stinger, Hammock said. The more deadly venom, a thick liquid, “like a milkshake,” is produced later, if the threat continues.

It’s a clever strategy, Hammock explained, because the deadly true venom uses a lot of proteins and peptides that are costly for the scorpion to make.

So instead it tries to get by with a faster acting and more painful toxin that doesn’t kill, but is easier to make.

The findings are reported in this week’s online edition of Proceedings of the National Academy of Sciences.

The first scorpion weapon, what Hammock calls a pretoxin, gets its kick largely from potassium salts that block receptors in animal cells, rapidly causing severe pain.

Salt in the wounds…

Fly UI

Tuesday, January 21st, 2003

Clever. Disturbingly clever. The Fly UI invites being peed on:

I have seen one of the finest instances of user interface design ever, and I saw it in the men’s room at Schipol airport in Amsterdam.

In each of the urinals, there is a little printed blue fly. It looks a lot like a real fly, but it’s definitely iconic – you’re not supposed to believe it’s a real fly. It’s printed near the drain, and slightly to the left.

I asked a user interface designer I knew at Nortel about this, who happened to be Dutch and who was familiar with this particular piece of toilet technology. And he told me that washrooms are much cleaner when these flies are there. Presumably because they encourage, in a very subtle way, good aim.

Now I love this kind of interface, because it’s so psychologically clever. If they had put big circular targets, and arrows with a little printed message “pee here!” (like it would probably be if anybody ever tried such a thing in America), it would backfire. A certain percentage of men would deliberately try to disobey this instruction.

But this innocuous little fly just invites being peed upon, if such a thing makes any sense, but in a non-insistent, gentle, and entirely effective way. If you’re the user interface specialist Donald Norman, I suppose you’d say the fly affords being peed on.

This is particularly funny if you’ve read Norman’s The Design of Everyday Things.

DVD Menu Design

Monday, January 20th, 2003

I can’t believe how useless — pretty but useless — most DVD menus are, and Don Norman, guest columnist on Alertbox, agrees with me in his (year-old) column, DVD Menu Design:

Designers of DVDs have failed to profit from the lessons of previous media: Computer software, Internet web pages, and even WAP phones. As a result, the DVD menu structure is getting more and more baroque, less and less usable, less pleasurable, less effective.

I thought I had it bad navigating through multiple menus just to get to the next episode of Buffy:

Memento, a fascinating movie, has a website-like presentation, filled with hidden words and hyperjumps to tantalizingly vague images that move about the screen. In theory, this is sophisticated hypertext, exploring the story subtleties in a non-linear fashion that mirrors the time distortion of the film. But the treatment does not live up to the theory. First, the film is actually linear, so the text fights the story it is trying to enhance. Didn’t the designer listen to the interview with the director on the very same DVD disk? Yes, the film rearranges time, linearly, in reverse (well, almost). The director carefully points out in the interview that you cannot delete or rearrange any section without destroying the entire whole. In other words, the film — unlike the commentary — is fixed in structure.

When I rented Memento, I didn’t explore the DVD — in part because we were visiting family, and they hated it. Anyway, this next bit applies to DVDs in general:

But even if you think that this is not a flaw, that a commentary can differ from the movie, the more serious flaw is that hypertext just doesn’t work on a DVD. The DVD is slow, not like a desktop PC. Finding another section on the disk takes time — measured in seconds — and so although the viewer at first marvels at the cleverness of the site, it does not take long for the marvel to deteriorate to disenchantment. “Do we have to keep going through this?” my family asked me when I patiently tried exploring the text. “Nope,” I answered, and with relief went back to the main menu.

Killer Drugs

Monday, January 20th, 2003

I love exposés on drug silliness, and Reason‘s Killer Drugs, offers up some good material on PCP (phencyclidine), the famous veterinary anesthetic turned street drug:

“Everything people used to say about marijuana is true of angel dust.” So claimed Robert DuPont, director of the National Institute on Drug Abuse, in 1977.
[...]
Back in the 1920s and ’30s, police spoke just as confidently about a link between marijuana and violence. The Federal Bureau of Narcotics portrayed marijuana as “the killer drug,” giving men “the lust to kill, unreasonably and without motive.”

One of the first such reports came from a Texas police captain who claimed habitual marijuana users “become very violent, especially when they become angry, and will attack an officer even if a gun is drawn.” He added that they “seem to have no fear,” are “insensible to pain,” and display “abnormal strength,” so that “it will take several men to handle one man.”

This description is eerily similar to contemporary stories about PCP users, whose rage and superhuman strength are said to resemble those of the Incredible Hulk.

It seems that the police have quite a history of facing super-criminals “hopped up” on illegal drugs. When it wasn’t “reefer madness” that had southern sheriffs worried, it was “coked up Negroes” who could take a bullet to the heart and keep on coming. In the lab, these drugs don’t seem to demonstrate quite so much super-soldier potential:

In a 1988 review of 350 journal articles on PCP in humans, the psychiatrist Martin Brecher and his colleagues noted that high doses of PCP can produce “severe agitation and hyperactivity,” along with “cognitive disorganization, disorientation, hallucinations, and paranoia.” Combined with the drug’s anesthetic effect, which makes users less sensitive to pain and therefore harder to restrain, such acute reactions have contributed to PCP’s fearsome image.

Yet in their search of the literature, Brecher and his co-authors found only three documented cases in which people under the influence of PCP alone had committed acts of violence. They also noted that between 1959 and 1965, when PCP was tested as a human anesthetic, it was given to hundreds of patients, but “not a single case of violence was reported.”

Brecher and his colleagues concluded that “PCP does not live up to its reputation as a violence-inducing drug.” That does not mean PCP users are never violent. But when they are, their behavior cannot be understood as a straightforward effect of the drug.

If I may repeat an important point, when PCP was tested as a human anesthetic, it was given to hundreds of patients, but “not a single case of violence was reported.” And here’s the real point: drug crime isn’t because of drugs; it’s because of drug prohibition:

An analysis of New York City homicides committed in 1988 and identified as “crack-related” found that 85 percent grew out of black-market disputes. Only one homicide out of 118 involved a perpetrator who was high on crack.

Such findings put crime statistics in a different light. “In cases where we know or suspect a motive,” reports a D.C. police spokesman, “over one-third of the killings are drug-related.” If so, that is an indictment of the drug laws, not PCP. The Saint Valentine’s Day Massacre could be called “alcohol-related,” but not because Al Capone’s thugs were drunk.

Mecca-Cola Launches Across Mideast To Protest US Policy

Monday, January 20th, 2003

Surreal. From Mecca-Cola Launches Across Mideast To Protest US Policy:

French company Mecca-Cola, which sells its cola to protest U.S. foreign policy, announced its product launch across the Middle East on Thursday.

The company, which has sold its slightly less sweet version of the classic soft drink across Europe for the past two months, has signed sales and distribution agreements with local companies to distribute its cola brand across most of the Middle East and North Africa, its founder, Tawfik Mathlouthi, told a news conference in Dubai.

“Cola is the pre-eminent symbol of U.S. culture,” said Mathlouthi, adding that his company, by targeting the market shares of Coca-Cola Co. (KO) and PepsiCo Inc. (PEP), hopes to send a message to the U.S. administration that Muslims want a just peace between Israelis and Palestinians.

Mathlouthi, a French national of Tunisian origin, set up the company with EUR25,000 of his own funds. He has an agreement with a French factory that allows the company to produce his cola as and when the company receives orders, thereby reducing startup costs.

He also plans to set up a $3 million-$4 million factory in Jebel Ali, Dubai’s industrial free zone, to provide half of the Middle East’s demand.

The company’s product range — soon to include a coffee-flavored cola, as well as tonic, orange and lemon drinks — will go on sale in the Gulf region in one-and-a-half months’ time, once the product receives official sales approval.

Mecca-Cola will donate materials worth 10% of its profits to Palestinian children’s charities and 10% to Catholic charities in Europe. The remaining 80% covers business costs, such as advertising, marketing and tax.

A few things caught my eye. If “Cola is the pre-eminent symbol of U.S. culture,” isn’t selling cola an odd way to protest U.S. cultural imperialism? Is the mix of charities a shrewd political move? I wasn’t expecting 10% of its profits to got to Catholic charities — which must seem the French equivalent to Muslim charities to the Tunisian owner? And why is the U.S. the only place on earth where bottled coffee-flavored drinks don’t sell?

Fans Howl in Protest as Judge Decides X-Men Aren’t Human

Monday, January 20th, 2003

It seems the alt.nerd.obsessive types have an even looser grasp on reality than I realized. From Fans Howl in Protest as Judge Decides X-Men Aren’t Human:

Marvel subsidiary Toy Biz Inc. pushed Judge Barzilay to declare its heroes nonhuman so it could win a lower duty rate on action figures imported from China in the mid-1990s. At the time, tariffs put higher duties on dolls than toys. According to the U.S. tariff code, human figures are dolls, while figures representing animals or “creatures,” such as monsters and robots, are deemed toys.

To Brian Wilkinson, editor of the online site X-Fan, Marvel’s argument is appalling. The X-Men — mere creatures? “This is almost unthinkable,” he says. “Marvel’s super heroes are supposed to be as human as you or I. They live in New York. They have families and go to work. And now they’re no longer human?”

Foreign Scientists Are Stranded By Post-9/11 Security Concerns

Monday, January 20th, 2003

This hits a bit close to home — well, not to me, but to my Irish scientist friends — and to a mutual acquaintance who’s back in Ireland. From Foreign Scientists Are Stranded By Post-9/11 Security Concerns:

Heng Zhu, a genomics whiz and post-doctoral fellow at Yale University, is a meticulously careful molecular biologist. Last April, however, he made a careless mistake.

Dr. Zhu, 35 years old, let his U.S. work visa expire and had to return to his native China before the State Department would consider issuing him a new one. Nearly 10 months later, he’s still waiting in Beijing to find out if he can come back, despite letters, phone calls and petition drives by Yale officials and other supporters. His absence has derailed work under a $1.5 million National Institutes of Health grant to understand how thousands of genes work, a process that could ultimately aid drug discovery.