They would become the middle class

Sunday, August 17th, 2025

In Western Europe, Peter Frost notes, a consensus emerged on the need to execute violent males so that law-abiding people could live in peace:

By the Late Middle Ages, courts were condemning to death between 0.5 and 1% of all men in each generation, with perhaps just as many dying at the scene of the crime or in prison while awaiting trial. The pool of violent men dried up until most murders occurred under conditions of jealousy, intoxication or extreme stress. As a result, the homicide rate fell from 20–40 homicides per 100,000 in the Late Middle Ages to 0.5–1 per 100,000 in the mid-20th century.

People could now get ahead through trade and work, rather than through theft and plunder. This new, pacified environment favored the growth of the market economy and the success of those who possessed the necessary skills, especially literacy, numeracy and budgeting. They would become the middle class.

Sparkling Protein sounds like a joke

Friday, August 15th, 2025

Sparkling ProteinAs an experienced whey protein consumer, I was surprised to hear that Sparkling Protein was a thing, but I can now confirm Cremieux Recueil’s assessment that it does in fact look and taste like diet soda:

The development process for clear whey is fascinating. I’m going to stylize it, so bear with me.

A beverage team wanted protein that could disappear in a fruit drink—no milkiness, no haze (i.e., low turbidity)—at a tart pH. But there’s a problem with most protein sources, and it’s that they clump and throw a fog at the pH fruit drinks live at, around the protein’s isoelectric point. So in the early development of clear whey, everything looked like watered-down yoghurt.

So, researchers worked the problem the way any process-oriented person would: they tightened the loop between hypotheses, trials, and measurements, and gave the whole thing a few passes.

In the first pass, they swapped the protein. Whey protein concentrate was out because it had too many minerals and residuals that encourage haze. Whey protein isolate was swapped in— it’s cleaner, lower ash—and this helped, but only a little. Turbidity meters still screamed “cloudy” and the human eye could usually tell, too.

In the second pass, they controlled the ions. They dialed down calcium and phosphate, tested deionized water, played with ionic strength… clarity improved, but still not enough.

In the third pass, they changed when the acid hits. Dumping citric or malic acid into a neutral protein slurry was creating localized pH shocks and microaggregates that never fully redispersed. Pre-acidifying the protein and then spray-drying it—so the powder arrived ‘at pH’—produced a much better first mix. You might actually drink this stuff at this point.

In the fourth pass, the researchers tried to tame the heat. Heat is required for safety (see: pasteurization), but it denatures and links proteins. This isn’t a bioavailability issue, but more of a clumping one. They mapped time-temperature curves, shaved seconds off of their high-temperature short-time pasteurization steps, minimized hold times, and did anything they could to avoid shear/heat combinations that built up irreversible aggregates.

In the fifth pass, they fine-cut the protein itself. Light enzymatic hydrolysis (peptide cuts!) knocked down viscosity and reduced the tendency to form visible aggregates, but made the mix more bitter. That forced a second project: set a narrow ‘degree of hydrolysis’ window and pair it with flavor systems that mask any remaining protein notes without slipping into clearly ‘diet drink’ aftertastes.

In the sixth pass, the idea was to stress the mixture like the real world: run centrifuge clarity checks, catalogue particle-size distributions, do cold/ambient/40C holds, freeze-thaw, check carbonation compatibility, and do bottle trials. If the mixture had sufficiently low turbidity with meaningful protein load and stability for a few weeks, it would be ready to go. Fail, adjust, and repeat this process until the goal is achieved.

At the end of the day, clear whey was the product of a robust process window and an iterative discovery process. Since the discovery was trial-and-error with a clear goal in mind, it might even be more appropriate to say that clear whey wasn’t discovered, but was instead, ‘de-risked’: a finicky protein had its manufacturing controls tightened until it started behaving like a cooperative beverage input. Huzzah!

I preferred it watered down with unsweetened (but flavored) sparkling water.

The North Sea and the Baltic form the core zone of certain tendencies

Thursday, August 14th, 2025

DNA from human remains is showing us how different populations have evolved over time, Peter Frost explains, not only during prehistory but also well into recorded history:

This evolution has affected a wide range of mental and behavioral traits: cognitive ability, time preference, propensity for violence, monotony avoidance, rule following and empathy, among others.

[…]

Why did the North Sea overtake the Mediterranean in international trade? Certainly, the latter region was adversely affected by the Arab conquests of the Middle East and North Africa. But the economic decline began much earlier. Shipwrecks on the bottom of the Mediterranean have been dated overwhelmingly to the time between the first century BC and the first century AD. Silver mining in Spain and Cyprus likewise fell sharply after the first century AD, as shown by lead contamination of Greenland’s ice sheet.

This decline occurred not only before the Arab conquests of the seventh and eighth centuries, but also before the barbarian invasions of the fourth and fifth and the Imperial Crisis of the third. And it seems inconsistent with modern economic thinking: bigger markets should create economies of scale, as well as a better match between supply and demand. So what caused things to go wrong?

[…]

One cause was the low level of social trust. People trusted only their close friends and relatives, keeping everyone else at arm’s length. As a result, economic activity was bottled up within family networks, the major exception being physical marketplaces where buyer and seller could meet face to face. Because the market principle remained trapped within small pockets of space and time, it could not generalize to all transactions in Roman society. An economy of markets never evolved into a true market economy.

[…]

One [other cause] was a deterioration of physical health, as indicated by the length of long bones belonging to over 10,000 adult men and women born between 500 BC and 750 AD. The data show a steady decrease from the second century BC, reaching a low point in the second half of the first century AD, followed by a slow recovery and then a dramatic recovery from the fifth century AD.

[…]

The study’s authors concluded that the Romans created not only an integrated Mediterranean economy but also “the first integrated disease regime”.

[…]

The other cause was a decrease in average cognitive ability. Fewer people could master the skills of numeracy, literacy and budgeting that are so essential to economic activity.

This decline was driven by an uncoupling of reproductive success from economic success—as I argued in a previous article. The wealthy were no longer using their wealth to bring children into the world. A rich man might prefer to leave his wife for a younger woman of low social status, often adopting her children. Or he might never marry. The resulting fall in cognitive ability can be seen in DNA retrieved from the human remains of that period.

[…]

The North Sea and the Baltic form the core zone of certain tendencies that, for at least a millennium, have prevailed north and west of a line running from Trieste to St. Petersburg, i.e., the “Hajnal line.” These are tendencies toward individualism, the nuclear family, late marriage and solitary living, as well as a greater willingness to trust strangers and form bonds of impersonal prosociality.

Such tendencies didn’t come into being with the market economy — they arose long before for an unrelated reason. But they did provide the best behavioral conditions for a market economy once the possibility of creating one emerged.

Skilled immigrants often constitute an espionage risk

Wednesday, August 13th, 2025

Given the reality of mixed loyalties, Arctotherium notes, it shouldn’t be surprising that skilled immigrants often constitute an espionage risk:

Take the infamous Pakistani nuclear physicist AQ Khan. In 1961, he moved to West Berlin as a foreign student, then to the Netherlands and finally Belgium to finish his education, graduating with a Doctorate in Engineering in 1972. Khan was undoubtedly among the best and brightest of Pakistan, the sort of high-agency STEM genius that brain drain advocates hold up as America’s greatest strength. Was allowing A.Q. Khan into the West a good decision? No.

Khan got a position at the Physics Dynamics Research Laboratory, a Dutch firm specializing in uranium enrichment via centrifuge. He stole centrifuge designs and blueprints, and after returning to Pakistan set up an international network of illicit suppliers for centrifuge parts using his contacts, leading to the 1998 Pakistani nuclear bomb. From there, he diffused nuclear technology further. The North Korean, Iranian and Libyan nuclear programs all trace back to A.Q. Khan. Pakistan has had multiple serious nuclear war scares with India in the last five years. North Korea, which has a history of doing things like axe-murder Americans, can act with relative impunity thanks to its nuclear arsenal, and Israel and the US recently bombed Iran over their nuclear program.

There are many examples from the US. For instance, Noshir Gowadia, an Indian Parsi designer of the B-2 Spirit stealth bomber, and Chi Mak, who worked on nuclear submarines, both sold secrets to China.

This doesn’t sound a lot like culture

Monday, July 28th, 2025

Culture Transplant by Garett JonesGarett Jones has finished his Singapore Trilogy, Hive Mind, 10% Less Democracy, and The Culture Transplant:

One way to think about the book is to think of the person vs. situation debate in psychology. The question was this: what explains people’s behaviors better, their current life situation broadly speaking or their stable persona? The latter we now call trait theory — because it is about people’s stable psychological dispositions — and won the evidence debate, at least, academically. Things haven’t improved much for situationism since then with the downfall of previously popular experiments such as the Stanford prison experiment, and Rosenhan’s psych ward study. So instead of thinking just about typical westerners, we can also think of humanity at large. Sometimes people move around (immigrate). Thinking of each ethnic group as a person to be explained, we can thus look at whether the same ethno-person behaves similarly in different situations, say, whether they live in Somalia, Sweden, or USA. Here we must clarify that there are some issues with measurement of many psychological traits. We don’t really, in general, have perfect scales so that we can track people’s absolute standing on some trait across time and place (we simply don’t know how to construct such tests). We can, however, track relative differences. So we can see whether Somalis living in Somalia (taken as a country) perform well economically, and we can check whether Somalis who moved to USA or Sweden perform well economically. In each case we find that they do rather poorly everywhere we find them, again, taken as a group. We can repeat this method for any other set of natio-ethno groups across various countries, to see whether the relative differences remain relatively consistent across situations.

[…]

Anyway, so if you count patents or anything else really, you will find that a few large and relatively productive countries produce most of everything new in the world.

[…]

The world in general depends on the right tail inventing, innovating, researching, and building. This is just as true within a country as it is between them. As such, everybody loses when the few clusters in the world that contain the most such right tail people are disrupted. We see this disruption all over the Western world, but especially in the most critical places. Time and money is wasted on diversity (read: anti-meritocratic) hiring, communist-like indoctrination, and the parading of the mentally ill in public spaces (drag shows, pride events). This must come at a cost of progress. Criminal and unproductive foreigners are imported to the most productive places on Earth where they can cause maximum disruption (the capitals of Western Europe, Californian cities). This is crazy and not even in migrants’ own long-term interest. However, modern Western politics seems to have forgotten everything about long-term interests (massive COVID debts, short-sighted democratic vote buying). I could go on, but you get the point.

Jones spends a chapter talking about the unique Chinese experience in Asia. This is basically just the thesis of
World on Fire by Amy Chua, but from a positive perspective. Not about ethnic conflict, but about how much better off the South Asians with more Chinese neighbors are. The Chinese may own most of their countries, but if their own salaries and standard of living increases by some substantial percentage, we have to ask ourselves how much self-determination is worth.

[…]

Obviously, ‘culture’ that transfers with people even when they lose their native language (and native culture in any normal sense), and also stays present across sometimes 200+ years in a new country, this doesn’t sound a lot like culture, but it does sound like genetics.

[…]

He seems to want to stay within the Overton window, but go pretty close to the edge, so that the reader will draw their own conclusions, and perhaps seek out some of the evidence slightly to the right of the evidence the book covers

The mice that received psilocybin had a 30% increased lifespan

Friday, July 25th, 2025

Researchers have discovered that the active compound in psychedelic mushrooms can extend lifespan and reduce cellular aging by 50% in human cells and 30% in elderly mice:

The team from Emory University are calling it the first ever long-term study evaluating the systemic effects of psilocybin in aged mice. The animals were the equivalent of 60 to 65 in biological human years, and exhibited hair loss and greying, as well as reduced physical activity.

The mice were dosed with psilocin, the active ingredient in psilocybin that appears once the latter is broken down during digestion. The mice received a low level at first, and eventually with a higher dose of 15 milligrams once a month for 10 months.

Within the first 3 months, the mice receiving psilocybin exhibited signs of youth, including fewer instances of greying and hair loss — including a reversal of these symptoms — and a general improvement in physical activity. By trial’s end, the mice that received psilocybin had a 30% increased lifespan on average than the control group.

To date, more than 150 clinical studies have been completed or are ongoing for examining psilocybin in the treatment of various clinical conditions, including anxiety, depression, addiction, neurodegenerative diseases like Alzheimer’s, chronic physical pain, and more.

The authors cite a study from 2020 which found that a single-dose of psilocybin can improve debilitating physical and psychological symptoms with improvements lasting up to and beyond 5 years post-dosage.

[…]

The scientists also tested the effects of psilocin on human fibroblast cells from the lung in vitro, continually dosing them with the psychoactive compound or a placebo until they reached replicative senescence, or the point at which the cell has divided around 50 times and then stopped.

Psilocin treatment of 10 micrograms resulted in a 29% extension of cellular lifespan, characterized by delayed exhaustion of proliferative potential, increased cumulative population doublings, and decreased population doubling time. Strikingly, when increased to 100 micrograms, 29% lifespan extension became 57%.

The psilocin-dosed fibroblasts were also observed to have increased SIRT1 activity, and a preserved telomere length.

When questioned about the source of the number, he then claimed on multiple occasions that the number actually came from someone else, and that journalists had distorted his argument

Thursday, July 17th, 2025

Adam Strandberg works on metabolism and has run into the claim that chess grandmasters burn 6000 calories per day during tournaments:

I assumed when I dug into it that I would find a specific methodological error. But while methods enter the story, the real problem is that the number was completely made up.

As far as I can tell, the “patient zero” that caused this claim to become so widespread is this 2019 ESPN article:

Robert Sapolsky, who studies stress in primates at Stanford University, says a chess player can burn up to 6,000 calories a day while playing in a tournament, three times what an average person consumes in a day. Based on breathing rates (which triple during competition), blood pressure (which elevates) and muscle contractions before, during and after major tournaments, Sapolsky suggests that grandmasters’ stress responses to chess are on par with what elite athletes experience.

This story was then picked up by many outlets, such as CNBC, Men’s Health, Inc, GQ, Marginal Revolution, and Joe Rogan.

So the claim came from Robert Sapolsky. However, a Google Scholar search turned up no primary literature from him on the topic. Fortunately, someone on Reddit was also curious and shared an email from Professor Sapolsky explaining the number. He first references a footnote from his 1994 book Why Zebras Don’t Get Ulcers:

The definitive study on chess players was carried out by the physiologist Leroy DuBeck and his graduate student Charlotte Leedy. They wired up chess players in order to measure their breathing rates, blood pressure, muscle contractions, and so on, and monitored the players before, during, and after major tournaments. They found tripling of breathing rates, muscle contractions, systolic blood pressures that soared to over 200—exactly the sort of thing seen in athletes during physical competition. See the original report, Leedy’s thesis, “The effects of tournament chess playing on selected physiological responses in players of varying aspirations and abilities” (Temple University, 1975) or their brief report (Leedy, C., and DuBeck, L. 1971. Physiological changes during tournament chess. Chess Life and Review, 708). In a telephone conversation, DuBeck also tells the story of the international match in the early 1970s between grand masters Bent Larson and Bobby Fischer, in which the former had to be given antihypertensive medication in the middle of his losing match; his blood pressure remained elevated for days afterward. And for that special chess fan out there who just can’t get enough of this subject, may I suggest as the perfect gift a copy of Glezerov, V., and Sobol, E. 1987. Hygienic evaluation of the changes in work capacity of young chess players during training. Gigiena i Sanitariia 24, in the original Russian.

This doesn’t say anything about calories, though the “tripling of breathing rates” matches part of the ESPN quote. He goes on:

The figure of 6K calories/day is an extrapolation that DuBeck generated, based on those measures and the typical duration of tournaments. Obviously, it’s a pretty soft, squishy number. I’d asked the ESPN people to mention that the 6K was an indirectly derived measure, the number of calories shouldn’t be presented as gospel, so if they were going to cite the 6K, they should cite these caveats as well. But I guess the caveats didn’t make the editing process…

Hope that helps.

Robert Sapolsky

[…]

To summarize: a grad student took physiological measurements of 11 ordinary chess players (not grandmasters). They reported in a summary in a chess magazine that the maximum chest movement rate they measured in a 10 second period was almost three times that of an average measurement from a different study. Robert Sapolsky then cited this thesis in his popular book, dropping the distinction between maximum and average to give a 3X breathing rate. He later took the 3X number and multiplied that by 2000 calories per day to get the number 6000, adding the “grandmaster” rhetorical fluorish along the way. He spread this fact through his own talks at Stanford and through interviews with journalists, who accurately repeated him. When questioned about the source of the number, he then claimed on multiple occasions that the number actually came from someone else, and that journalists had distorted his argument.

You have a better measure of how hard your workout was than your watch or heart-rate monitor can provide

Monday, July 7th, 2025

A new study published in the International Journal of Sports Physiology and Performance compares seven different ways of calculating training load:

Four of them are variations on a concept known as TRIMP, which is short for “training impulse” and is based on heart rate measurements, using equations that account for lactate levels, breathing thresholds, and other details. A fifth uses heart-rate variability, and a sixth uses a subjective rating of effort. (Most fitness wearables, by the way, likely use a combination of the above methods, though their exact algorithms are typically proprietary.) The seventh method is the NASA questionnaire, which we’ll come back to.

The gold standard against which all these methods were compared is the “acute performance decrement,” or APD. Basically, you do an all-out time trial, then you do your workout, then you do another all-out time trial. Your APD is how much slower the second time-trial is compared to the first one, as a measure of how much the workout took out of you.

[…]

The performance test was running at VO2 max pace until exhaustion. When they were fresh, the runners lasted just under six minutes on average. After the one-hour easy run, their APD was 20.7 percent, meaning they gave up 20.7 percent earlier in the post-workout VO2 max run. After the medium-intensity run, the APD was 30.6 percent; after the long intervals, it was 35.9 percent; after the short intervals, it was 29.8 percent.

So how well were each of the seven training load calculations able to predict this APD? The short answer is: not very well.

[…]

The NASA questionnaire, on the other hand, bears a striking resemblance to the APD data, and the statistical analysis confirms that it’s a good predictor. In other words, it’s the only one of the seven calculations tested that, according to this study, accurately reflects how exhausted you are after a workout.

It’s called the NASA Task Load Index, or NASA-TLX, and was developed in the 1980s. It’s simply a set of six questions that ask you to rate the mental demand, physical demand, temporal demand (how rushed were you?), performance (how well did you do?), effort, and frustration of a task. You answer each of these questions on a scale of 1 to 100, then the six scores are averaged—and presto, you have a better measure of how hard your workout was than your watch or heart-rate monitor can provide.

Next thing he knew, the cops had him pinned to the floor, and he had no memory of what he’d just done

Saturday, July 5th, 2025

Chaos by Tom O’NeillAs Tom O’Neill (Chaos: Charles Manson, the CIA, and the Secret History of the Sixties) flipped through “Jolly” West’s papers, he found signs that the CIA psychiatrist was associated with the JFK assassination:

According to a first-person account that Ruby produced with a ghostwriter—published in newspapers in a scenario close to Susan Atkins’s, and again involving Lawrence Schiller—Ruby “lost [his] senses” when he pulled out his gun. Next thing he knew, the cops had him pinned to the floor, and he had no memory of what he’d just done. “What am I doing here?” he asked. “What are you guys jumping on me for?” A psychiatric analysis solicited by Ruby’s defense attorneys said he’d suffered “a ‘fugue state’ with subsequent amnesia.”

On the advice of his attorney at the time, Ruby said he’d murdered Oswald to spare the widowed First Lady, Jackie Kennedy, the ordeal of testifying against Oswald at trial. Another of Ruby’s attorneys, Melvin Belli, later wrote that Ruby had “a blank spot in his memory,” and that any explanation he provided was simply “confabulating.” Potential justifications “had been poured like water into the vacuum in his pathologically receptive memory and, once there, had solidified like cement.”

Seemingly as soon as the story of Oswald’s murder hit the presses, Jolly West tried to insinuate himself into the case. He hoped to assemble a panel of “experts in behavior problems” to weigh in on Ruby’s mental state. He took the extraordinary measure of approaching Judge Joe B. Brown, who’d impaneled the grand jury that indicted Ruby. West wanted the judge to appoint him to the case. At that time, police hadn’t revealed any substantial information about Ruby, his psychological condition, or his possible motive. And West was vague about his motive, too. Three documents among his papers said he’d been “asked” by someone, though he never said who, to seek the appointment from Brown “a few days after the assassination,” a fact never before made public.

[…]

Once Dr. Smith was driving Ruby’s legal team, one of his first acts was to request a new psychiatric examination of Ruby. He had one candidate in mind: Dr. Louis Jolyon West, whom he noted in a court brief had enjoyed acclaim for his studies of brainwashed American POWs. Perhaps, Smith wrote, West could use his “highly qualified” skills as a hypnotist and an administrator of the “truth serum, sodium pentothal” to help Ruby regain his memory of the shooting. (West may have rewarded Smith for the plum assignment by helping him land a teaching position at Oklahoma.)

[…]

West emerged from Ruby’s cell to announce that the previously sane inmate had undergone “an acute psychotic break” sometime during the preceding “forty-eight hours.” Whatever transpired between West and Ruby in that cell, only the two of them could say; there were no witnesses. West asserted that Ruby “was now positively insane.” The condition appeared to be “unshakable” and “fixed.”

In a sworn affidavit accompanying his diagnosis, West described a completely unhinged man who hallucinated, heard voices, and had suddenly acquired the unshakeable belief that a new holocaust was under way in America. “Last night,” West wrote, “the patient became convinced that all Jews in America were being slaughtered. This was in retaliation for him, Jack Ruby, the Jew who was responsible for ‘all the trouble.’” The delusions were so real that Ruby had crawled under the table to hide from the killers. He said he’d “seen his own brother tortured, horribly mutilated, castrated, and burned in the street outside the jail. He could still hear the screams… The orders for this terrible ‘pogrom’ must have come from Washington.”

West said the trouble had started sometime in the evening before the exam, when Ruby ran headfirst into his cell wall in an apparent suicide attempt. But Ruby’s jailer, Sheriff Bill Decker, shrugged it off as a cry for attention. “He rubbed his head on the wall enough that we had to put a little Merthiolate [antiseptic] on it,” Decker told a reporter. “That’s all.”

From that day forward, every doctor who examined Ruby made similar diagnoses: he was delusional. West, however, was hardly the first to have evaluated him. By then nearly half a dozen psychiatrists, many equally renowned, had taken stock of Ruby’s condition, finding him essentially compos mentis. West had been briefed on these opinions, but in his hubris, he wrote that he’d hardly bothered with them, having been “unable to read them until earlier today on the airplane. Tonight, my own findings make it clear that there has been an acute change in the patient’s condition since these earlier studies were carried out.”

The change was too “acute” for Judge Brown’s liking. In the preceding five months, he’d spent many hours in the courtroom with Ruby, and he’d never witnessed anything resembling the behavior West described. Presumably it wasn’t lost on him that this was the same doctor who’d clamored to see Ruby months earlier. After the judge heard West’s report, he ordered a second opinion, saying, “I would like some real disinterested doctors to examine Ruby for my own benefit. I want to get the truth out of it.”

That opinion came from Dr. William Beavers, who examined Ruby two days after West. Beavers’s report to the judge, never before made public, confirmed West’s findings. Ruby “became agitated,” Beavers wrote, and “asked if I did not hear the sounds of torture that were going on.” Like Judge Brown, he was alarmed by the abruptness of Ruby’s disintegration. He considered the possibility that Ruby was malingering—but quickly ruled it out, explaining that it was “highly unlikely that this individual could have convincingly faked hallucinations.” Beavers wondered if Ruby had been tampered with or drugged by an outsider. “The possibility of a toxic psychosis could be entertained,” he wrote, “but is considered unlikely because of the protected situation.”

[…]

But the most relevant insight came from Dr. Jay Shurley, his good friend of forty-five years, who’d worked with West at Lackland Air Force Base and the University of Oklahoma. Shurley was one of the few colleagues who admitted that West was an employee of the CIA. I asked him if he thought West would’ve accepted an assignment from the CIA to scramble Jack Ruby’s mind.

“I feel sort of disloyal to Jolly’s memory,” Shurley said, “but I have to be honest with you, my gut feeling would be yes. He would be capable of that.” Calling West “a very complex character,” he explained, “he had a little problem with grandiosity. He would not be averse at all to having influenced American history in some way or other, whether he got the credit for it or not… Jolly had a real streak of—I guess you’d call it patriotism. If the president asked him to do something, or somebody in a higher office… he would break his back to do that without asking too many questions.”

“Even if it meant distorting American history?”

“I suppose so,” Shurley said. “He was a pretty fearless kind of guy.”

[…]

The President’s Commission on the Assassination of President Kennedy—better known as the Warren Commission, after its chairman, Chief Justice of the United States Earl Warren—had some dubious members in its ranks. One was Allen Dulles, the former CIA director. Kennedy had fired him two years earlier, after he’d bungled the Bay of Pigs invasion. Another was the official CIA liaison to the group, Richard Helms, soon to become the agency’s director. A protégé of Dulles, Helms was the longtime secret employer of Jolly West, and one of the few agency officials aware of MKULTRA. But no one else on the commission—except, presumably, Dulles, who started the program—was aware that a CIA “asset” trained in mind control had assumed responsibility for the psychiatric care of Jack Ruby, whom the commission regarded as their “most important witness.”

In June 1964, Earl Warren and others from the group flew to Dallas to give Ruby a hearing in the interrogation room of the county jail. The bulk of his testimony was a morass of paranoid rambling. He begged Warren to get him out of Dallas. “The Jewish people are being exterminated at this moment,” he warned. “I know I won’t live to see you another time… Do I sound sort of screwy?” He demanded to speak with a Jew, whispering frantically, “You have to get me to Washington! They’re cutting off the arms and legs of Jewish children in Albuquerque and El Paso!”

[…]

The group was required to investigate the CIA as a routine suspect in the assassination of a sitting president. Neither Dulles nor Helms ever reported their knowledge of West’s employment by the CIA.

[…]

If the CIA wanted to shut Ruby up, what was it that he had on it? Burt Griffin, an attorney for the Warren Commission, appeared before the HSCA to say that he and his partner had nearly confirmed Ruby’s ties to gunrunning schemes by anti-Castro Cubans, who were shipping arms from the United States to Cuba in hopes of deposing the dictator.

At the time, Griffin had no idea that the CIA sponsored these gunrunning schemes. In March 1964—when Ruby was weeks away from his “examination” by Jolly West—Griffin and his partner approached Richard Helms, requesting all the information the CIA had on Ruby. They believed it was possible “that Ruby was involved in illegal dealings with Cuban elements who might have had contact with Oswald.”

Helms offered only a curt reply: “The CIA would be very limited in its possibility of assisting.” Griffin was baffled—this was someone who was supposed to be helping him. He appealed again. By the time Helms mustered a response, months had passed, and West had long since paid his fateful visit to Ruby. “An examination of Agency files,” Helms wrote, “has produced no information on Jack Ruby or his activities.”

As for Jolly West, he also did his part to keep Ruby untainted from any whiff of conspiracy. As the Warren Commission tried to divine Ruby’s motive, West sent a confidential letter to Earl Warren himself, a copy of which I discovered in the HSCA’s files. Dated June 23, 1964, and addressed to “My Dear Mr. Chief Justice,” West’s note contends that his “examinations” of Ruby gave him unique insight into the man’s “motivations for the murder.” (This despite the fact that West had said Ruby was “positively insane.”) He was confident that Ruby had acted in an “irrational and unpremeditated” manner when he shot Oswald, “wanting to prove that the Jews—through himself—loved their President and were not cowards.” Moreover, West asserted that Ruby “had never seen [Oswald] in his life” before his involvement in the Kennedy assassination broke. Without consent from his patient or his patient’s lawyers, West was offering confidential medical assessments tailored to political ends. “Please let me know if there is anything else that I can do to be of assistance,” he added.

Was it possible that the Manson murders were an MKULTRA experiment gone wrong?

Saturday, June 21st, 2025

Chaos by Tom O’NeillWith Alan Scheflin, a forensic psychologist and law professor who’d written a book on MKULTRA, Tom O’Neill (Chaos: Charles Manson, the CIA, and the Secret History of the Sixties) laid out a circumstantial case linking “Jolly” West to Charles Manson:

Was it possible, I asked, that the Manson murders were an MKULTRA experiment gone wrong? “No,” he said, “an MKULTRA experiment gone right.”

In the back of my mind was the most confounding passage in Helter Skelter—one that I’d underlined, highlighted, and finally torn out and taped above my computer. “The most puzzling question of all,” Bugliosi wrote, was how Manson had turned his docile followers into remorseless killers. Even with the LSD, the sex, the isolation, the sleep deprivation, the social abandonment, there had to be “some intangible quality… It may be something that he learned from others.” Something that he learned from others. Those had become the six most pivotal words in the book for me.

Are we born to succeed or are we made to succeed?

Friday, June 20th, 2025

Are we born to succeed or are we made to succeed? Lizah van der Aart illustrates a recent Nature Human Behaviour article:

SES 1
SES 2
SES 3
SES 4
SES 5
SES 6
SES 7

Cells exposed to erythritol exhibited a substantial increase in oxidative stress

Sunday, June 15th, 2025

Sugar substitute erythritol may impair cellular functions essential to maintaining brain blood vessel health, according to researchers at the University of Colorado Boulder:

Erythritol has become a fixture in the ingredient lists of protein bars, low-calorie beverages, and diabetic-friendly baked goods. Its appeal lies in its sweetness-to-calorie ratio, roughly 60–80% as sweet as sucrose with a tiny fraction of the energy yield, and its negligible effect on blood glucose.

[…]

Concerns about erythritol’s safety have escalated following epidemiological studies linking higher plasma concentrations with increased cardiovascular and cerebrovascular events.

[…]

Cells exposed to erythritol exhibited a substantial increase in oxidative stress. Reactive oxygen species levels rose by approximately 75% relative to untreated controls. Antioxidant defense markers were also elevated, with SOD-1 expression increasing by approximately 45% and catalase by approximately 25%.

Nitric oxide production declined by nearly 20% in response to erythritol.

Even before his CIA connections came out, West’s experiments got him in plenty of trouble

Saturday, June 14th, 2025

Chaos by Tom O’NeillDespite the furtive nature of “Jolly” West’s research, Tom O’Neill explains (in Chaos: Charles Manson, the CIA, and the Secret History of the Sixties), he could be surprisingly garrulous

Among the press clippings in his file were two items from Portland, Oregon, newspapers, both dated October 1963—the murky period between his Oklahoma hypnosis studies and the Haight-Ashbury Project. West had given an address to the Mental Health Association of Oregon, letting it slip that he was inducing insanity in the lab. He framed these studies as positive developments: they might someday cure mental illness.

“We are at the dawning of a new era,” West told the crowd, “learning for the first time to produce temporary mental derangement in the laboratory.” The Oregon Journal noted that West “listed the new hallucination drug LSD, along with other drugs, hypnosis, and sleep deprivation as some of the things that [he was] using to produce temporary mental illness effects in normal people.” Reporting that West had done “extensive work” with LSD, the Journal continued: “The most important contribution of the drug so far is in producing model mental illnesses.”

Almost fifteen years later, besieged by reporters after the New York Times alleged that he’d taken part in MKULTRA’s secret LSD experimentation program, West insisted that all of his LSD work “had been confined to animals,” denying any CIA affiliation. When reporters pointed out that he’d received an awful lot of money from the agency, he retorted that he’d had no idea that the Geschickter Fund and other sources were CIA fronts. Legally, the CIA was obligated to tell the University of Oklahoma that one of its faculty had been on the agency payroll. Oklahoma revealed a heavily redacted memo saying that an unnamed professor—West, I confirmed through financial records—had been investigating “a number of dissociative phenomena” on humans “in the lab,” including an exceptionally rare clinical disorder known as “latah,” “a neurotic condition marked by automatic obedience.”

None of the allegations harmed West’s reputation. By then he’d left Oklahoma for UCLA, where he offered a steady stream of denials and continued to thrive through his retirement in 1988. Irascible and arrogant, he was quick to threaten lawsuits when anyone brought up the charges. Sometimes he threw in diversionary tactics: in a 1991 rebuttal, he claimed, “My secret connection to Washington, D.C. is not as a spook, but rather as a confidential advisor to Presidents… From Eisenhower to Bush, Democrat and Republican Presidents alike have freely sought and received my counsel.” In a 1993 letter to the editor of the UCLA Bruin, he had the temerity to compare his accusers to Nazi propagandists “in Goebbels’ tradition of the Big Lie.” West added, “I have never taken part in ‘mind-control’ experiments funded by the CIA or anybody else”: a statement belied by his own files.

Even before his CIA connections came out, West’s experiments got him in plenty of trouble. In 1972, he announced plans to build a lab in an abandoned Nike Missile base in the Santa Monica Mountains. He would call it “The Center for the Study and Reduction of Violence,” or the Violence Center, for short. There, in perfect isolation, he could study the origins and control of human violence by experimenting on prisoners. Governor Ronald Reagan gave the Violence Center a full-throated endorsement.

But West’s proposal for grant money landed him in hot water. He planned to test radical forms of behavior modification, implanting electrodes and “remote monitoring devices” in prisoners’ brains. A federal investigation concluded that the program involved “coercive methods” that threatened “privacy and self-determination.”

The committee’s disclosures stymied the Violence Center before it got past the planning stages. The California legislature vetoed the project; UCLA’s student body rose up in protest of West. And this, to reiterate, was before anyone had a clue about his CIA work.

His friends called him “Jolly”

Saturday, June 7th, 2025

Chaos by Tom O’NeillThrough his research on the Haight-Ashbury Free Medical Clinic, Tom O’Neill learned that yet another shadowy researcher kept an office there — as he explains in Chaos: Charles Manson, the CIA, and the Secret History of the Sixties — and this researcher’s work with LSD had clearer, more nefarious ties to the CIA than any of the others:

At least his name wasn’t Smith this time: he was Dr. Louis Jolyon West. His friends called him “Jolly,” for his middle name, his impressive girth, and his oversized personality.

[…]

Born in Brooklyn in 1924, West had enlisted in the army air force during World War II, eventually rising to the rank of colonel. He came to my interest when I learned that he’d accepted an office at the Haight-Ashbury clinic from David Smith himself to recruit subjects for LSD research.

Earlier in his career, West researched methods of controlling human behavior at Cornell University. During the Korean War, he helped to “deprogram” returning prisoners of war who’d allegedly been brainwashed. His success earned him national attention. Around the same time, he achieved still more fame when he joined civil rights activists like his friend the actor Charlton Heston, as well as Dr. Martin Luther King Jr., in marches demanding equal rights for African Americans. Ironically, while he was fighting for the rights of some, he was suspected of infringing on those of others. His detractors alleged that through the fifties and early sixties, at air force bases in Texas and Oklahoma, he performed experiments on unwitting subjects using LSD and hypnosis.

After John F. Kennedy was assassinated in November 1963, West psychiatrically examined Jack Ruby, who’d murdered Kennedy’s assassin, Lee Harvey Oswald. Not long before Ruby was due to testify for the Warren Commission, West examined him alone in his jail cell. He emerged to report that Ruby had suffered an “acute psychotic break.” Sure enough, Ruby’s testimony before the commission succeeded only in making him sound unhinged. He could never fully explain why he’d decided to kill Oswald.

Through the seventies, journalists linked West to the CIA’s mind-control research program, MKULTRA. He denied all involvement, vigorously attacking anyone who suggested otherwise. He kept up those attacks until his death in 1999. Then seventy-four, he’d been diagnosed with metastatic cancer, and he prevailed on his son to help him commit suicide with a cocktail of pills.

[…]

West had spent the last decades of his career at UCLA, where he’d become something of an institution, heading the psychiatry department’s renowned neuroscience center; the university had named an auditorium in his honor. When I called the school, I learned that he’d donated his papers to them, but since no one had asked to see them, they’d never been processed. No one had so much as opened the first box. I would be the first reporter to look at them.

[…]

Late in the fall of 1966, Jolly West arrived in San Francisco to study hippies and LSD. The Bay Area had seen an unprecedented migration of middle-class youth and an explosion of recreational drug use. West felt he had to witness it firsthand. He secured a government grant and took a yearlong sabbatical from his professorship at the University of Oklahoma, nominally to pursue a fellowship at Stanford, although that school had no record of his participation in a program there.

West was a square—tall, broad, and crew cut, with an all-American look in keeping with his military past. If he wanted a good glimpse of the hippies, he’d have to blend in. He started cobbling together a new wardrobe and skipping haircuts.

At least he had a solid knowledge base. The summer of love had yet to come, and the Tate–LaBianca murders were still years away, but West would effectively predict them both. In a 1967 psychiatry textbook, he’d contributed a chapter called “Hallucinogens,” warning students of a “remarkable substance” percolating through college campuses and into cities across the United States. It was LSD, known to leave users “unusually susceptible and emotionally labile” as it caused a “loosening of ego structure.” That language was reminiscent of the “reprogramming” spiel that Charles Manson would soon develop, urging his acid-tripping followers to “negate their egos.”

When West cautioned against the “LSD cults” springing up in America’s “bohemian” quarters, he described exactly the kind of disenchanted wanderers who’d flock to a personality like Manson’s in the years to come. West had a hunch that alienated kids “with a pathological desire to withdraw from reality” would crave “shared forbidden activity in a group setting to provide a sense of belonging.”

Another paper by West, 1965’ s “Dangers of Hypnosis,” foresaw the rise of dangerous groups led by “crackpots” who hypnotized their followers into violent criminality. Contrary to the prevailing science at the time, West asserted that hypnosis could make people so pliable that they’d violate their moral codes. Scarier still, they’d have no memory of it afterward. Just because such outcomes were rare, he argued, didn’t mean they were impossible.

West cited two cases to back up his argument: a double murder in Copenhagen committed by a hypno-programmed man, and a “military offense” induced experimentally at an undisclosed U.S. Army base. He “personally knew” of two other instances, and he’d “heard on excellent authority” of three more, but he didn’t elaborate. Later, I’d get a sense of what, or who, he might have had in mind.

When he arrived in Haight-Ashbury, then, West was the only scientist in the world who’d predicted the emergence of potentially violent “LSD cults.” How had he learned so much about acid? You’d never know from his published writing that he’d conducted innumerable experiments with it. In San Francisco, he hoped to conduct more still.

In the Haight, West found a group of kindred spirits at David Smith’s new clinic, where plenty of shrinks from the “straight world” were basking in hippiedom. Getting his bearings at the HAFMC, he arranged for the use of a crumbling Victorian house on nearby Frederick Street, where he opened what he described as a “laboratory” disguised as a “hippie crash pad.” This would serve as a “semi-permanent observation post,” granting him an up-close-and-personal look at the youth. He installed six graduate students in the “pad,” telling them to “dress like hippies” and “lure” itinerant kids into the apartment. Passersby were welcome to do as they pleased and stay as long as they liked, as long as they didn’t mind grad students taking copious notes on their behavior.

The “pad” opened in June 1967, at the dawn of the summer of love. West took pains to ensure that it felt realistic, decorating it “with posters, flowers and paint.” Thus was born the Haight-Ashbury Project, as he called it, or “HAP,” for short. For the next six months, he undertook “an ongoing program of intensive interdisciplinary study into the life and times of the hippies.”

To drum up hippie business, West stopped by the HAFMC, where David Smith could furnish willing subjects. Smith even gave him an office. Having a nationally recognized researcher like West working out of the HAFMC would attract sorely needed government funding.

“We helped him with research,” Smith told me. He was sympathetic to West’s project, even though he admitted that he never bothered to find out what it was, or what its objectives were. He assumed that West, like himself, was diagnosing “psychedelic patterns in the counterculture,” trends that others had dismissed as boorish fads.

“They came over and interviewed kids that came into our clinic,” Smith said of West and his students. “He wanted to know, ‘What is a hippie?’” Smith reminded me that “this was a very new population… the fact that large numbers of white middle-class kids would use illicit drugs was a total mindblower.”

Who was paying for all this? According to records in West’s files, his “crash pad” was funded by the Foundations Fund for Research in Psychiatry, Inc., which had bankrolled a number of his other projects, too, across decades and institutions. For reasons soon to be clear, I concluded that the Foundations Fund was a front for the CIA.

This wouldn’t have been the agency’s first “disguised laboratory” in San Francisco. A few years earlier, the evocatively titled Operation Midnight Climax had seen CIA operatives open at least three Bay Area safe houses disguised as upscale bordellos, kitted out with one-way mirrors and kinky photographs. A spy named George Hunter White and his colleagues hired prostitutes to entice prospective johns to the homes, where the men were served cocktails laced with acid. White scrupulously observed the ensuing activities, whatever they were. The goal was to see if LSD, paired with sex, could be used to coax sensitive information from the men—something of a psychedelic honeypot experiment. White so enjoyed the proceedings that he had a portable toilet and a mini-fridge installed on his side of the mirror, so he could watch the action and swill martinis without taking a bathroom break. He later wrote to his CIA handler, “I was a very minor missionary, actually a heretic, but I toiled wholeheartedly in the vineyards because it was fun, fun, fun. Where else could a red-blooded American boy lie, kill and cheat, steal, deceive, rape and pillage with the sanction and blessing of the All-Highest? Pretty Good Stuff, Brudder!”

West knew better than to commit such sentiments to paper, but by 1967 he’d “toiled wholeheartedly in the vineyards,” too. Before he moved to the Haight, he’d supervised a similar study in Oklahoma City, hiring informants to infiltrate teenage gangs and engender “a fundamental change” in “basic moral, religious or political matters.” The title of the project was Mass Conversion. As I was soon to see, its funds came from Sidney J. Gottlieb, the head of the CIA’s MKULTRA program.

[…]

Bob Conrich, a cofounder of the HAFMC, saw through the ruse right away. West “walked into the clinic one day and my first reaction was that he’d read too many Tim Leary interviews,” Conrich wrote to me. West was a careerist in hippies’ clothing. “What I remember is his enthusiasm for the whole ‘summer of love’ thing, which seemed exaggerated and insincere.”

[…]

He soon concluded that the constellation of sex, drugs, and communalism shining over the Haight that summer was “doomed to fail”: “The very chemicals they use will inevitably enervate them as individuals and bleed the energies of the hippie movement to its death.” He called this an “ineffable tragedy,” but it’s hard to imagine he saw it that way. For West, the failure of sixties idealism was the most desirable outcome—one that he was quite possibly working toward. A copy of his résumé from this period hints at the thrust of his research. He was at work on a book called Experimental Psychopathology: The Induction of Abnormal States. But he never published it. Nor, on the surface, would “the induction of abnormal states” dovetail with the stated goals of his HAP. By the early seventies he removed the title from his résumé and never mentioned it again.

Stephen Pittel, the forensic psychologist, worked briefly with West in 1968 and referred to him as “the only benevolent psychopath I ever met.” The man could “charm the pants off of anyone, and manipulate people into doing all sorts of things they didn’t want to do.”

[…]

The grad students hired to man West’s “crash pad” laboratory were assigned to keep diaries of their work. In unguarded moments, nearly all these students admitted that something didn’t add up. They weren’t sure what they were supposed to be doing, or why West was there. And often he wasn’t there.

[…]

When West made one of his rare appearances, he was “dressed funny,” like a hippie; sometimes he would have friends in tow, costumed just as poorly. Collins wrote, “The rest of us tended to look to them in trying to understand what we were supposed to do or what Jolly wanted. Their general reply was that this was a good opportunity to have fun. I gather that they did. They spent a good deal of the time stoned.”

[…]

Pressed for specific guidelines, West exuded “phoniness and dishonesty,” suggesting that the students answer sweeping, high-flown questions about the Haight, such as “Is this an asphalt Sherwood Forest?” She “got the impression that this question had already been answered.”

[…]

Albert Hofmann, the Swiss scientist who’d discovered its hallucinogenic qualities in 1943, described it as a “sacred drug” that gestured toward “the mystical experience of a deeper, comprehensive reality.” The actor Cary Grant, on the advice of his shrink, took some one hundred LSD trips during their weekly meetings in the late fifties, experiencing a “rebirth” and picturing himself “as a giant penis launching off from Earth like a spaceship.”

Charles Fischer, a drug researcher who worked with David Smith, described to me the early perceptions of acid, when “trips” were planned like literal journeys. “Very few people took LSD without having somebody being a ‘trip leader,’” Fischer said. The suggestibility from LSD was akin to hypnosis—and Jolly West, of course, had known well enough to study the two in tandem. “You can tell somebody to hurt somebody, but you call it something else,” Fischer explained. “Hammer the nail into the wood, and the wood, perhaps, is a human being… [It] could result in some violent activity, even though LSD was considered a love drug.”

[…]

Full-fledged U.S. research into LSD began soon after the end of World War II, when American intelligence learned that the USSR was developing a program to influence human behavior through drugs and hypnosis. The United States believed that the Soviets could extract information from people without their knowledge, program them to make false confessions, and perhaps persuade them to kill on command.

The CIA, then in its infancy, saw mind control as a natural extension of communism, spreading like fire where the forces of unreason prevailed. In 1949 it launched Operation Bluebird, a mind-control program whose chipper name belied its brutal ambitions and its propensity for trampling on human rights. In its yen to best the Soviets, the CIA tested drugs on American citizens—most in federal penitentiaries or on military bases—who didn’t even know about, let alone consent to, the battery of procedures they underwent.

Their abuse found further justification in 1952, when, in Korea, captured American pilots admitted on national radio that they’d sprayed the Korean countryside with illegal biological weapons. It was a confession so beyond the pale that the CIA blamed Communists: the POWs must have been “brainwashed.” The word, a literal translation of the Chinese xi nao, didn’t appear in English before 1950.

[…]

Once the Korean War was over and the American POWs returned, the army brought in a team of scientists to “deprogram” them. Among those scientists was a young psychiatrist from Cornell, Dr. Louis J. West. He would later claim to have studied eighty-three prisoners of war, fifty-six of whom had been forced to make false confessions. West interviewed them at length, undoing the treacheries of the “thought reform” they’d undergone in enemy hands. He and his colleagues were credited with reintegrating the POWs into Western society and, maybe more important, getting them to renounce their claims about having used biological weapons.

West’s success with the POWs gained him entrée to the upper echelons of the intelligence community. As the Cold War bred paranoia, the CIA accelerated its mind-control efforts, and West, I learned, carved out a niche he’d occupy for decades to come. Initially, the agency wanted only to prevent further brainwashing by the Soviets. But the extraordinary power of psychotropic drugs, particularly LSD, was hard to ignore. Thus a defensive program became an offensive one. Operation Bluebird morphed into Operation Artichoke, a search for an all-purpose truth serum.

Dr. Sidney Gottlieb, a poisons expert who headed the chemical division of the CIA’s Technical Services Staff, had convinced the agency’s director, Allen Dulles, that mind-control ops were the future. Gottlieb, whose aptitude and amorality had earned him the nickname the “Black Sorcerer,” developed gadgetry straight out of schlocky sci-fi: high-potency stink bombs, swizzle sticks laced with drugs, exploding seashells, poisoned toothpaste, poisoned handkerchiefs, poisoned cigars, poisoned anything. Mind control became Gottlieb’s pet project. Dulles, convinced that the American dream was at stake, ensured that Gottlieb was well funded. In a speech at Princeton University, Dulles warned that Communist spies could turn the American mind into “a phonograph playing a disc put on its spindle by an outside genius over which it has no control.” Just days after those remarks, on April 13, 1953, he officially set Project MKULTRA into motion.

The project’s broadest goal was “to influence human behavior.” Under its umbrella were 149 subprojects, many involving research that used unwitting participants. Having persuaded an Indianapolis pharmaceutical company to replicate the Swiss formula for LSD, the CIA had a limitless domestic supply of its favorite new drug. The agency hoped to produce couriers who could embed hidden messages in their brains, to implant false memories and remove true ones in people without their awareness, to convert groups to opposing ideologies, and more. The loftiest objective was the creation of hypno-programmed assassins.

In their defense, CIA spooks weren’t above experimenting on themselves. The same substance that held the promise of controlling minds and quashing communism was used in churlish office pranks, with agents quietly slipping LSD into their colleagues’ drinks to achieve much needed “firsthand knowledge.” A plan to spike the punch bowl at the CIA Christmas party was quashed when higher-ups reminded the office that it could cause insanity.

The most sensitive work was conducted far from Langley—farmed out to scientists at colleges, hospitals, prisons, and military bases all over the United States and Canada. The CIA gave these scientists aliases, funneled money to them, and instructed them on how to conceal their research from prying eyes, including those of their unknowing subjects. Feeling that it was their patriotic duty, the scientists accepted their secret missions in defiance of the Hippocratic oath: “First, do no harm.”

In 1949, at the Nuremberg trials that adjudicated the crimes of World War II, the United States adopted the International Code for Human Experimentation: “A person must give full and informed consent before being used as a subject.” MKULTRA scientists flouted this code constantly, remorselessly—and in ways that stupefy the imagination. Their work encompassed everything from electronic brain stimulation to sensory deprivation to “induced pain” and “psychosis.” They sought ways to cause heart attacks, severe twitching, and intense cluster headaches.

[…]

Operated on a strict need-to-know basis, MKULTRA was so highly classified that when John McCone succeeded Dulles as CIA director late in 1961 he was not informed of its existence. Fewer than half a dozen agency brass were aware of MKULTRA at any period during its twenty-year history. When Gottlieb retired, in 1972 or ’73, the project retired with him.

[…]

Director Richard Helms ordered Gottlieb to destroy all MKULTRA files. In January 1973, the Technical Services Staff shredded countless documents describing the use of hallucinogens, including every known copy of a manual called “LSD: Some Un-Psychedelic Implications.”

[…]

In their haste to purge their misdeeds, the agents forgot about a cache of some sixteen thousand additional papers in an off-site warehouse. Even internally, those files would remain undiscovered for several years, but it was only a matter of time until the story broke; MKULTRA had become fodder for rumors around Washington.

In December 1974, the project finally came to light in a terrific flash of headlines and intrigue. Seymour Hersh reported it on the front page of the New York Times: “Huge C.I.A. Operation Reported in U.S. Against Antiwar Forces.”

[…]

First came the Church Committee and the Rockefeller Commission, each mentioned earlier regarding CHAOS and COINTELPRO. The Church Committee’s final report unveiled a 1957 internal evaluation of MKULTRA by the CIA’s inspector general. “Precautions must be taken,” the document warned, “to conceal these activities from the American public in general. The knowledge that the agency is engaging in unethical and illicit activities would have serious repercussions.” A 1963 review from the inspector general put it even more gravely: “A final phase of the testing of MKULTRA products places the rights and interests of U.S. citizens in jeopardy.”

In fact, as the Church Committee’s report went on, MKULTRA had caused the deaths of at least two American citizens. One was a psychiatric patient who’d been injected with a synthetic mescaline derivative. The other was Frank Olson, a CIA-contracted scientist who’d been unwittingly dosed with LSD at a small agency gathering in the backwoods of Maryland presided over by Gottlieb himself. Olson fell into an irreparable depression afterward, which led him to hurl himself out the window of a New York City hotel where agents had brought him for “treatment.” (Continued investigation by Olson’s son, Eric, strongly suggests that the CIA arranged for the agents to fake his suicide; they threw him out of the window themselves out of fear that he would blow the whistle on MKULTRA and the military’s use of biological weapons in the Korean War.)

[…]

Senators Ted Kennedy and Daniel Inouye subpoenaed a number of CIA spooks. Among them was Gottlieb, rousted from his retirement in California and forced to defend his actions before the Senate. Or rather, before some of the Senate. Gottlieb claimed that his heart condition precluded the possibility of his addressing the whole chamber; instead, he was installed in an anteroom, where he answered questions from a select group while the masses listened over a public address system.

As the New York Times pointed out, Gottlieb “managed to elude the lights and microphones and the crush of reporters waiting for him in the Senate hearing room.” He was spared the sight of the incredulity that spread over their faces as he admitted that he had destroyed MKULTRA’s files not to cover up “illegal activity,” but “because this material was sensitive and capable of being misunderstood.” He resented the harm done to his reputation, and he was loath to provide specifics about MKULTRA experiments, saying that he’d never witnessed any himself.

Gottlieb’s destruction of the MKULTRA files was a federal crime. It was investigated by the Justice Department in 1976, but, according to the Times, “quietly dropped.” His brutal courses of experimentation broke any number of laws, and his perjury that day did, too. But he was never prosecuted. He’d testified before the Senate only under the condition that he receive total criminal immunity.

[…]

Surviving records named eighty institutions, including forty-four universities and colleges, and 185 researchers, among them Louis J. West. The New York Times identified him, in a front-page lead story, no less, as one of seven suspected scientists who’d secretly participated in MKULTRA under academic cover. And yet not one researcher was ever federally investigated, and only two victims were ever notified. The Times had called MKULTRA “a secret twenty-five year, twenty-five million dollar effort by the CIA to learn how to control the human mind.” It looked like no one would suffer any consequences for it.

Griffin Bell, the Attorney General at the time of the revelations, told me the files never arrived at the Justice Department, despite Stansfield Turner’s sworn claim to the contrary. Bell said they must’ve just “fall[ en] through the cracks.” As for Turner himself, he told me he could no longer remember having testified that the CIA sent the files. “I’m just drawing a total blank here,” he said. I read his remarks back to him. “I guess I did testify about this,” he said. “Somebody fed me the stuff and I played it back.”

The New York Times ran twenty-seven stories on MKULTRA, eight on the front page. But no one in the press corps, and none of the senators involved, followed up to see that the promised investigations took place.

[…]

West’s archive comprised two hundred boxes, most of them full of ephemera. There were tons of press clippings. West had tracked the media’s coverage of assassinations, the CIA, aggression in cats, psychosurgery, capital punishment, alcoholism among Native Americans, behavior modification, and the civil rights movement, among other subjects. I was intrigued to see many clippings on the Manson murders, and papers by Roger Smith, David Smith, and Alan Rose.

[…]

On August 25, among a batch of research papers on hypnosis, I found them: letters between West and his CIA handler, “Sherman Grifford.”

I didn’t recognize the name, so as soon as I got home, I began tearing through every book I had that mentioned MKULTRA, hoping that it would jump out at me. In the first and most definitive of the bunch, John Marks’s The Search for the Manchurian Candidate, there it was, buried in a footnote: “CIA operators and agents all had cover names,” it said, “even in classified documents. Gottlieb was ‘Sherman R. Grifford.’”

So West really had lied all those years. Not only was he a part of MKULTRA, he’d corresponded with the “Black Sorcerer” of MKULTRA himself. Preserved in his files, the letters picked up midstream, with no prologue or preliminaries. The first one was dated June 11, 1953, a mere two months after MKULTRA started. West was then chief of psychiatric service at the airbase at Lackland, Texas.

Addressing Gottlieb as “S.G.,” he outlined the experiments he proposed to perform using a combination of psychotropic drugs and hypnosis. Enumerating short-and long-term goals, he offered a nine-point list, beginning with a plan to discover “the degree to which information can be extracted from presumably unwilling subjects (through hypnosis alone or in combination with certain drugs), possibly with subsequent amnesia for the interrogation and/ or alteration of the subject’s recollection of the information he formerly knew.” Another item proposed honing “techniques for implanting false information into particular subjects… or for inducing in them specific mental disorders.” West wanted to reverse someone’s belief system without his knowledge, and make it stick. He hoped to create “couriers” who would carry “a long and complex message” embedded secretly in their minds, and to study “the induction of trance-states by drugs.” All of these were the goals of MKULTRA, and they bore a striking resemblance to Manson’s accomplishments with his followers more than a decade later.

“Needless to say,” West added, the experiments “must eventually be put to test in practical trials in the field.”

West’s colleagues wouldn’t approve of his activities. He yearned to “cut down considerably the number of people who can properly call me to account.” Because he’d be using drugs that were “not on the Air Force list of standard preparations,” he wanted to secure “some sort of carte blanche.” (He would go on to suggest a number of security measures in his letters, including disguised funding, double envelopes, and false names.)

Next West addressed a sensitive matter: who would the guinea pigs be? He listed four groups—basic airmen, volunteers, patients, and “others, possibly including prisoners in the local stockade.” Only the volunteers would be paid. The others could be unwilling, and, though it wasn’t spelled out, unwitting. It’d be easier to preserve his secrecy if he was “inducing specific mental disorders” in people who already exhibited them. “Certain patients requiring hypnosis in therapy, or suffering from dissociative disorders (trances, fugues, amnesias, etc.) might lend themselves to our experiments.”

As if to prove his thoroughness, he affixed two addenda to his four-page letter, begging Gottlieb to get one of his superiors, a Major Robert Williams, “transferred to another base.” Williams was “an uncomfortably close scrutinizer of all my activities” who believed that hypnosis was “tampering with the soul,” West complained.

Gottlieb’s reply came on letterhead from “Chemrophyl Associates,” a front company he used to correspond with MKULTRA subcontractors. “My Good Friend,” he wrote, “I had been wondering whether your apparent rapid and comprehensive grasp of our problems could possibly be real… you have indeed developed an admirably accurate picture of exactly what we are after. For this I am deeply grateful.” He would arrange top-secret clearances for anyone who might become ensnared in their work, giving West “a separate sum” for the purchase of materials.

Gottlieb saluted his new recruit: “We have developed quite an asset in the relationship we are developing with you.”

West returned the camaraderie. “It makes me very happy to realize that you consider me ‘an asset,’” he replied. “Surely there is no more vital undertaking conceivable in these times.”

With that, the record of their correspondence ceased for nearly nine months. When it resumed, in April 1954, West had begun arrangements to relocate to the University of Oklahoma School of Medicine, which wanted him to head its psychiatry department. He would be a civilian again. Gottlieb commended his “new look,” noting, “it appears at the moment to be a move which would in the long run be beneficial for us.” He signed off intimately, “Give my regards to your family.”

West had lied to his prospective employer, writing, “My present job is purely clinical and I have been doing no research, classified or otherwise.” The university took him at his word. Now performing his duties for Gottlieb at both the university and the air force base, West asked the judge advocate at Lackland for permission to accept money from the Geschickter Fund for Medical Research, which he called “a non-profit private research foundation.” In fact, as the CIA later acknowledged, Geschickter was another of Gottlieb’s fictions, enabling him to keep West and other researchers properly paid.

[…]

In a paper titled “The Psychophysiological Studies of Hypnosis and Suggestibility,” he claimed to have achieved the impossible: he knew how to replace “true memories” with “false ones” in human beings without their knowledge. In case the CIA didn’t grasp the significance of this, he put it in layman’s terms: “It has been found to be feasible to take the memory of a definite event in the life of an individual and, through hypnotic suggestion, bring about the subsequent conscious recall to the effect that this event never actually took place, but that a different (fictional) event actually did occur.”

The document, marked “classified,” was right there in West’s files; I had to assume that the CIA had destroyed any copies. They’ve never publicly acknowledged West’s groundbreaking deed. He’d done it, he claimed, by administering “new drugs” effective in “speeding the induction of the hypnotic state and in deepening the trance that can be produced in given subjects.”

As in his initial experiments, West performed most of these psychiatric feats on mental health patients. “The necessity to obtain most of the subject material from a population of psychiatry patients made standardized observations very difficult,” he groused. In the report, which doubled as a request for continued funding—a successful request; West received government backing through 1965 at the least—he enthusiastically described a high-tech laboratory he planned to construct at Oklahoma. It would include “a special chamber [where] various hypnotic, pharmacologic, and sensory-environmental variables will be manipulated.”

West had hypnotized mental patients and “normal subjects” and exposed them to a host of drugs, including chlorpromazine, reserpine, amphetamines, and LSD—the same ones that David Smith would inject in his confined rodents about a decade later. Of course, at least two of these, LSD especially, would prove instrumental in the Manson Family’s group psychology.

[…]

Acid, he wrote, made people more difficult to hypnotize; it was better to pair hypnosis with long bouts of isolation and sleep deprivation. Using hypnotic suggestion, he claimed, “a person can be told that it is now a year later and during the course of this year many changes have taken place… so that it is now acceptable for him to discuss matters that he previously felt he should not discuss… An individual who insists he desires to do one thing will reveal that secretly he wishes just the opposite.”

Since West’s paper was light on specifics, it’s hard to know if it was only a ploy for more funding.

[…]

At the National Security Archives in D.C., I found the version of “The Psychophysiological Studies of Hypnosis and Suggestibility” that the CIA had turned over to the Senate. West’s name and affiliation were redacted, as expected. But what shocked me was that the Senate’s version didn’t include West’s nine-page attachment, but rather an unsigned summary. There was no mention of West’s triumphant accomplishment, the replacement of “the memory of a definite event in the life of an individual” with a “fictional event.”

In sworn testimony, the CIA said that everything it shared with Congress was intact except for the redactions of researchers’ and institutions’ names. Now it turned out they hadn’t just censored West’s report; they’d completely misrepresented its contents.

Where your sugar comes from matters just as much as how much you consume

Friday, June 6th, 2025

New research from Brigham Young University suggests that where your sugar comes from matters just as much as how much you consume:

In the most extensive analysis of its kind, researchers from BYU and institutions in Germany examined data from over 500,000 people across multiple continents. Their discovery? Sugars from drinks like soda and even fruit juice were consistently linked to a higher risk of developing type 2 diabetes (T2D). Surprisingly, sugars from other sources did not show this same risk. In fact, some were even linked to a lower risk.

[…]

With each additional 12-oz serving of sugar-sweetened beverages (i.e., soft drinks, energy drinks, and sports drinks) per day, the risk for developing T2D increased by 25%. This strong relationship showed that the increased risk began from the very first daily serving with no minimum threshold below which intake appeared to be safe.

With each additional 8-oz serving of fruit juice per day (i.e., 100% fruit juice, nectars and juice drinks), the risk for developing T2D increased by 5%.

The above risks are relative not absolute. For example, if the average person’s baseline risk of developing T2D is about 10%, four sodas a day could raise that to roughly 20%, not 100%.

Comparatively, 20 g/day intakes of total sucrose (table sugar) and total sugar (the sum of all naturally occurring and added sugars in the diet) showed an inverse association with T2D, hinting at a surprising protective association.

[…]

Sugar-sweetened beverages and fruit juice supply isolated sugars, leading to a greater glycemic impact that would overwhelm and disrupt liver metabolism, thereby increasing liver fat and insulin resistance.

On the other hand, dietary sugars consumed in or added to nutrient-dense foods, such as whole fruits, dairy products, or whole grains, do not cause metabolic overload in the liver. These embedded sugars elicit slower blood glucose responses due to accompanying fiber, fats, proteins, and other beneficial nutrients.