Suction Healing Device

Sunday, April 18th, 2010

No one really knows why, Cliff Kuang says, but applying suction dramatically speeds healing times for open wounds:

But for almost everyone, that treatment is out of reach — simply because the systems are expensive — rentals cost at least $100 a day and need to be recharged every six hours.

No more. Danielle Zurovcik, a doctoral student at MIT, has created a hand-powered suction-healing system that costs about $3. The device is composed of an airtight wound dressing, connected by a plastic tube to a cylinder with accordion-like folds. Squeezing it creates the suction, which lasts as long as there’s no air leak. What’s more, where regular dressings need to be replaced up to three times a day — a painful ordeal — the new cuff can be left on for several days.

You can thank your friendly FDA for keeping such cheap, unsafe medical devices out of the hands of the masses.

Race Riots 2.0

Saturday, April 17th, 2010

I recently mentioned how the tech-savvy hipster fad of forming flash mobs has been picked up by a less ironic demographic. Richard Spencer dubs the movement Race Riots 2.0:

If you live in one of America’s “vibrant” big cities, you’ve probably become aware of an alarming new trend in violent marauding — flash mobs. If you’re a tech geek, you’ve also probably become aware of this term, though in a far more benign context. More on that below — but first to the kinds of flash mobs that threaten your life.

This is one of those social phenomena, like immigrant crime, that the national media either ignores or else treats with heavy doses of misdirection and euphemism. One must thus turn to the less refined local news for the raw footage — such as these image from last summer captured by a Philadelphia drugstore’s surveillance camera.

The original flash mobs weren’t so mob-like:

Philadelphia: rioting. Antwerp: musical theater.

Consulting isn’t about advice

Friday, April 16th, 2010

Consulting isn’t about advice, as the story BCG offered Keith Yost $16,000 not to tell demonstrates:

Despite having no work or research experience outside of MIT, I was regularly advertised to clients as an expert with seemingly years of topical experience relevant to the case. We were so good at rephrasing our credentials that even I was surprised to find in each of my cases, even my very first case, that I was the most senior consultant on the team.

I quickly found out why so little had been invested in developing my Excel-craft. Analytical skills were overrated, for the simple reason that clients usually didn’t know why they had hired us. They sent us vague requests for proposal, we returned vague case proposals, and by the time we were hired, no one was the wiser as to why exactly we were there.

I got the feeling that our clients were simply trying to mimic successful businesses, and that as consultants, our earnings came from having the luck of being included in an elaborate cargo-cult ritual. In any case it fell to us to decide for ourselves what question we had been hired to answer, and as a matter of convenience, we elected to answer questions that we had already answered in the course of previous cases — no sense in doing new work when old work will do. The toolkit I brought with me from MIT was absolute overkill in this environment. Most of my day was spent thinking up and writing PowerPoint slides. Sometimes, I didn’t even need to write them — we had a service in India that could put together pretty good copy if you provided them with a sketch and some instructions.
[...]
What I could not get my head around was having to force-fit analysis to a conclusion. In one case, the question I was tasked with solving had a clear and unambiguous answer: By my estimate, the client’s plan of action had a net present discounted value of negative one billion dollars. Even after accounting for some degree of error in my reckoning, I could still be sure that theirs was a losing proposition. But the client did not want analysis that contradicted their own, and my manager told me plainly that it was not our place to question what the client wanted.
[...]
Early on, before I began case work, one manager I befriended gave me some advice. To survive, he told me, I needed to remember The Ratio. 50 percent of the job is nodding your head at whatever is being said. 20 percent is honest work and intelligent thinking. The remaining 30 percent is having the courage to speak up, but the wisdom to shut up when you are saying something that your manager does not want to hear.

I spoke up once. And when it became clear that I would be committing career suicide to press on, I shut up.
[...]
Nominally, my job was to provide advice and aid in my client’s decision-making process. In practice, my job consisted of sitting quietly and resisting the urge to dissent. Each day was like a punishment from Greek mythology; with every meeting my liver would grow anew to be eaten again by eagles.

Speeding Tickets Infographic

Friday, April 16th, 2010

This speeding tickets infographic puts some things in perspective:

(Hat tip to Graham’s Automatic Ballpoint.)

Rosetta Stone

Friday, April 16th, 2010

The Rosetta Stone is a Ptolemaic-era stele discovered by Napoleon’s troops during their occupation of Egypt and famous for its role in deciphering ancient Egyptian script, because it includes the same message in hieroglyphs, Demotic script, and classical Greek.

But what kind of message deserves to be inscribed in granite-hard rock in three different writing systems?

In essence, the Rosetta Stone is a tax amnesty given to the temple priests of the day, restoring the tax privileges they had traditionally enjoyed from more ancient times. Some scholars speculate that several copies of the Rosetta Stone must exist, as yet undiscovered, since this proclamation must have been made at many temples. The complete Greek portion, translated into English, is about 1600–1700 words in length, and is about 20 paragraphs long (average of 80 words per paragraph):

In the reign of the new king who was Lord of the diadems, great in glory, the stabilizer of Egypt, but also pious in matters relating to the gods, superior to his adversaries, rectifier of the life of men, Lord of the thirty-year periods like Hephaestus the Great, King like the Sun, the Great King of the Upper and Lower Lands, offspring of the Parent-loving gods, whom Hephaestus has approved, to whom the Sun has given victory, living image of Zeus, Son of the Sun, Ptolemy the ever-living, beloved by Ptah;

In the ninth year, when Aëtus, son of Aëtus, was priest of Alexander and of the Savior gods and the Brother gods and the Benefactor gods and the Parent-loving gods and the god Manifest and Gracious; Pyrrha, the daughter of Philinius, being athlophorus for Bernice Euergetis; Areia, the daughter of Diogenes, being canephorus for Arsinoë Philadelphus; Irene, the daughter of Ptolemy, being priestess of Arsinoë Philopator: on the fourth of the month Xanicus, or according to the Egyptians the eighteenth of Mecheir.

THE DECREE: The high priests and prophets, and those who enter the inner shrine in order to robe the gods, and those who wear the hawk’s wing, and the sacred scribes, and all the other priests who have assembled at Memphis before the king, from the various temples throughout the country, for the feast of his receiving the kingdom, even that of Ptolemy the ever-living, beloved by Ptah, the god Manifest and Gracious, which he received from his Father, being assembled in the temple in Memphis this day, declared: Since King Ptolemy, the ever-living, beloved by Ptah, the god Manifest and Gracious, the son of King Ptolemy and Queen Arsinoë, the Parent-loving gods, has done many benefactions to the temples and to those who dwell in them, and also to all those subject to his rule, being from the beginning a god born of a god and a goddess — like Horus, the son of Isis and Osirus, who came to the help of his Father Osirus; being benevolently disposed toward the gods, has concentrated to the temples revenues both of silver and of grain, and has generously undergone many expenses in order to lead Egypt to prosperity and to establish the temples… the gods have rewarded him with health, victory, power, and all other good things, his sovereignty to continue to him and his children forever.

If I had tax amnesty, I too would want it written in stone, in triplicate.

Incompetent Locals

Friday, April 16th, 2010

If the twentieth century and probably the twenty-first could be summed up with one banal truism, Joseph Fouché says, it would be this:

People prefer being ruled by an incompetent local who looks like them to being ruled by a competent outsider who doesn’t look like them.

T.E. Lawrence said as much:

Do not try to do too much with your own hands. Better the Arabs do it tolerably than that you do it perfectly. It is their war, and you are to help them, not to win it for them. Actually, also, under the very odd conditions of Arabia, your practical work will not be as good as, perhaps, you think it is.

The Expensive Gym Membership Effect

Friday, April 16th, 2010

One of Gretchen Rubin’s revelations from her Happiness Project is that people do not spend enough time thinking about how money could buy them some happiness and instead fall prey to the expensive gym membership effect:

The expensive-gym-membership effect is when you pay money for something in order to force yourself to make time for a priority.

Because you want to make yourself go to the gym, you pay a lot for a membership, with the thought, “Gosh, this costs so much, I’ll feel like I have to go to the gym!” Guess what. You won’t. The expensive-gym-membership effect is how gyms stay in business. They can’t afford to have a treadmill for every member, but they know a lot of paying members will never show up.

The effect is more general than that though:

Merely spending money on something doesn’t do much to push you along. You have to decide to make an activity a priority. Probably the reason you’re not taking long baths isn’t because you don’t have the right bath oil, but because you have three kids and no time. You buy the bath oil as an expression of your desire to change something in your life – but that purchase won’t do it.

The Blackboard Jungle of Kingston, Jamaica

Thursday, April 15th, 2010

While visiting her father’s side of the family, in Kingston, Jamaica, Miss Snuffleupagus, a London school teacher, decided to visit a school in the wrong part of town. Here’s how bad it was:

Round about the classrooms I go, chatting to children. Everyone is black, children, teachers, workmen. The classrooms have broken blackboards, broken tables and broken chairs. Nothing on the scale of African poverty, but certainly much worse than the girls boarding school in the Jamaican countryside. There is some noise coming from the classrooms, and every now and then, I see a child run around the corner into a door, clearly rushing, because he doesn’t want to get into trouble.

The children aren’t bright like they were at the girls’ boarding school. Jamaica has a stringent testing system which streams the children from school to school. These children are at the bottom of the ladder. So I cannot have conversations about freedom with them. We chat about their favourite subjects, and they smile awkwardly with embarrassment.

When I walk into classrooms, the boys and girls rise immediately. ‘Good morning visitor!’ they chant, some of them waving with delight. I remember my own children in London, who often laugh at visitors, mocking them as soon as they turn to leave.

I chat to one of the teachers who is in charge of the SEN (special needs) children. These children are always the most difficult in any school. And they are always the children that every school (in England) tries to palm off to another, to make their chances of raising standards into a possibility. I ask her what it is like to work at the school. She explains that she has been there for over 10 years, but that at first, it took her a while to get used to the difficulties of the inner city. I ask her what she means.

Well, 80% of their children come from single parent homes. About 50% rarely see their fathers. Some 50 children have no parents at all, and as the state doesn’t look after them as we do here, well… The stats are far worse than any school I have ever worked in, or indeed even exists in England. She explains how this has a negative effect on the children’s behaviour and that sometimes they can be very rude.

So I ask her to tell me about a time when a child did something really bad. She takes a deep breath, and I pull my chair closer to her desk, waiting to hear the delectable details. ‘Well,’ she starts, pausing as if to catch her breath, ‘once I told a boy to sit down, and…’ I lean in closer. ‘And what…? I ask, as if in a Roman coliseum, waiting for the gore. She whispers… ‘He said he didn’t want to sit down.’ Her eyes open wide as she sits back, satisfied that she has shocked me to the core.

‘What’s it like at your school in inner city London?’ She asks.

I smile. ‘Much the same.’ I lie. What else can I say? I’m simply astonished.

Having spent the morning with them, I thank the Principal for having me. She shakes my hand vigorously, smiling from ear to ear. ‘Thank you, thank you,’ she squeals, ‘thank you for not being too intimidated to come.’

Thou, Thee, Ye, You

Thursday, April 15th, 2010

I was recently reading The Civilising Mission, and I couldn’t help but notice that its header includes a line from Kipling’s “The White Man’s Burden”:

The blame of those ye better, The hate of those ye guard

I suppose most modern English speakers vaguely recognize ye as an archaic form of you:

You is the second-person personal pronoun in Modern English. Ye was the original nominative form; the oblique/objective form is you (functioning originally as both accusative and dative), and the possessive is your or yours.

I know you. Ye know me.

Ye is not the only archaic form of you we’ve got, as thou already knowest:

In standard English, you is both singular and plural; it always takes a verb form that originally marked the word as plural, such as you are. This was not always so. Early Modern English distinguished between the plural you and the singular thou.

This distinction was lost in modern English due to the importation from France of a Romance linguistic feature which is commonly called the T-V distinction. This distinction made the plural forms more respectful and deferential; they were used to address strangers and social superiors. This distinction ultimately led to familiar thou becoming obsolete in standard English, although this did not happen in other languages such as French.

Because thou is now seen primarily in literary sources such as the King James Bible (often directed to God, who is traditionally addressed in the familiar) or Shakespeare (often in dramatic dialogs, e.g. “Wherefore art thou Romeo?”), many modern anglophones erroneously perceive it as more formal, rather than familiar (case in point: in Star Wars: The Empire Strikes Back, Darth Vader addresses the Emperor saying, “What is thy bidding, my master?”).

Naturally, once y’all use you for both singular and plural, y’all need a new plural:

Because you is both singular and plural, various English dialects have attempted to revive the distinction between a singular and plural you to avoid confusion between the two uses. This is typically done by adding a new plural form; examples of new plurals sometimes seen and heard are y’all, or you-all (primarily in the southern United States and African American Vernacular English), you guys (in the U.S., particularly in Midwest, Northeast, and West Coast, in Canada, and in Australia; regardless of the genders of those referred to), you lot (in the UK), youse (in Scotland), youse guys (in the U.S., particularly in New York City region, Philadelphia, Michigan’s Upper Peninsula and rural Canada; also spelt without the E), and you-uns/yinz (Western Pennsylvania, The Appalachians).

The Third Nuclear Age

Thursday, April 15th, 2010

Sometimes a gun isn’t just a gun, Richard Fernandez says:

About 740,000 assault rifles and pistols are stored in Swiss homes or in private possession. Nobody knows the exactly how many firearms are in circulation, but there may be up to 1.3 million firearms in Switzerland. Despite this you are more likely to murdered by knife than by gun. “Police statistics for the year 2006 records 34 killings or attempted killings involving firearms, compared to 69 cases involving bladed weapons and 16 cases of unarmed assault. Cases of assault resulting in bodily harm numbered 89 (firearms) and 526 (bladed weapons)”

And sometimes a nuke isn’t just a nuke:

The country with the largest known deposits of uranium, which tested 7 nuclear devices on its soil in the 50s and whose head of government isn’t even going to attend President Obama’s nonproliferation summit won’t keep statesmen up at night. It’s Australia.

The danger posed by weapons depends on their “human modifiers”:

Guns in the hands of the Swiss are not the same as guns in the hands of a Sudanese militia. Enriched uranium in Australia is no worry; but uranium in the hands of Kim Jong Il is.

His real point is that we’ve moved from the First Nuclear Age, with two nuclear superpowers policing their own allies and satellites, to a Second Nuclear Age, of many nuclear powers — and perhaps to a Third Nuclear Age, in which even non-state actors may wield nuclear weapons:

The key to understanding the difficulty of the nonproliferation problem is to realize that the core of the difficulty is a human one. Above all it is a question of who has nuclear weapons; it is one of legitimacy and rationality rather than technology. Bracken noted that the Second Nuclear Age required a “massive change to intelligence programs” precisely because the problem consisted of monitoring the who. The billions of dollars that the Obama administration is prepared to spend on buying fancy locks and safeguards for Pakistan and other Second Age countries may be more useful in terms of developing intelligence contacts within their nuclear establishments than for buying the safeguards themselves. It’s not what’s in the vaults that is the problem, it is who can get to use them.

Why Startups are Agile and Opportunistic

Wednesday, April 14th, 2010

A startup is an organization formed to search for a repeatable and scalable business model, Steve Blank says:

At a board meeting last week I watched as the young startup CEO delivered bad news. “Our current plan isn’t working. We can’t scale the company. Each sale requires us to handhold the customer and takes way too long to close. But I think I know how to fix it.” He took a deep breath, looked around the boardroom table and then proceeded to outline a radical reconfiguration of the product line (repackaging the products rather than reengineering them) and a change in sales strategy, focusing on a different customer segment. Some of the junior investors blew a gasket. “We invested in the plan you sold us on.” A few investors suggested he add new product features, others suggested firing the VP of Sales. I noticed that through all of this, the lead VC just sat back and listened.

Finally, when everyone else had their turn, the grey-haired VC turned to the founder and said, “If you do what we tell you to do and fail, we’ll fire you. And if you do what you think is right and you fail, we may also fire you. But at least you’d be executing your plan not ours. Go with your gut and do what you think the market is telling you. That’s why we invested in you.” He turned to the other VC’s and added, “That’s why we write the checks and entrepreneurs run the company.”

Tax collection is the most efficient department of government

Wednesday, April 14th, 2010

Tax collection is the most efficient department of government, Nick Szabo says; its efficiency rivals that of many private sector institutions:

The tax collector’s incentives are aligned with the other branches of their government in a task that benefits all associated with the government, namely the collection of their revenue. No organization of any type collects more revenue with fewer expenditures than tax collection agencies. Of course, they have the advantage of coercion, but they must overcome measurement problems that are often the same as other users of accounting systems, such as owners of large companies. It is not surprising, then, that tax collectors have sometimes pioneered value measurement techniques, and often have been the first to bring them into large scale use.

Mis-measuring value means taxing various things too much or too little:

On a larger scale, the Laffer curve may be the most important economic law of political history. Adams[2] uses it to explain the rise and fall of empires. The most successful governments have been implicitly guided by their own incentives — both their short-term desire for revenue and their long-term success against other governments — to optimize their revenues according to the Laffer Curve.

Governments that overburdened their taxpayers, such as the Soviet Union and later Roman Empire, ended up on the dust-heap of history, while governments that collected below the optimum were often conquered by their better-funded neighbors.

Democratic governments may maintain high tax revenues over historical time by more peaceful means than conquering underfunded states. They are the first states in history with tax revenues so high relative to external threats that they have the luxury of spending most of the money in non-military areas. Their tax regimes have operated closer to the Laffer optimum than those of most previous kinds of governments. (Alternatively, this luxury may be made possible by the efficiency of nuclear weapons in deterring attack rather than the increased incentives of democracies to optimize to tax collection).

When we apply the Laffer curve to examining the relative impact of tax rules on various industries, we conclude that the desire to optimize tax revenues causes tax collectors to want to accurately measure the income or wealth being taxed. Measuring value is crucial to determining the taxpayer’s incentives to avoid or evade the tax or opt out of the taxed activity.

For their part, taxpayers can and do spoof these measurements in various ways. Most tax shelter schemes, for example, are based on the taxpayer minimizing reported value while optimizing actual, private value. Tax collection involves a measurement game with unaligned incentives, similar to but even more severe than measurement games between owner and employee, investor and management, store and shopper, and plaintiff-defendant (or judge-guilty party).

As with accounting rules, legal damage rules, or contractual terms, the choice of tax rules involves trading off complexity (or, more generally, the costs of measurement) for more accurate measures of value. And worst of all, as with the other rule-making problems, rule choices ultimately ground out on subjective measures of value. Thus a vast number of cases are left where the tax code is unfair or can be avoided. Since tax collectors are not mind readers, tax rules and judgments must substitute for actual subjective values its judgments of what the “reasonable” or “average” person’s preferences would be in the situation.
[...]
The resulting rules often seem arbitrary, but they are not. They are trade-offs, often non-obvious but brilliant, between the costs of measuring more value with greater accuracy and extra revenue extracted thereby. However, the value measurement problem is hardly unique to tax collection. It is endemic when assessing damages in contract and tort law, and when devising fines punishments in administrative and criminal law.

Many private sector rules found in contracts, accounting, and other institutions also have the quality that they use highly non-obvious measures of value that turn out, upon close examination, to be brilliant solutions to seemingly intractable problems of mind-reading and the unacceptable complexity of covering all cases or contingencies. Such measurement problems occur in every kind of economic system or relationship. The best solutions civilization has developed to solve them are in most institutions brilliant but highly imperfect. There is vast room for improvement, but failed large-scale experiments in attempts to improve these measures can be devastating.

The Laffer curve and measurement costs can also be used to analyze the relative benefits of various tax collection schemes to government. Prior to the industrial revolution, for example, the income tax was infeasible. Most taxes were on the prices of commodities sold, or on various ad-hoc measures of wealth such as the frontage of one’s house. (This measurement game resulted in the very tall and deep but narrow houses that can still be found in some European cities such as Amsterdam. The stairs are so narrow that even normal furniture has to be hauled up to the upper story and then through a window with a small crane, itself a common feature on these houses).

Prior to the industrial revolution, incomes were often a very private matter. However, starting in England in the early nineteenth century, large firms grew to an increasing proportion of the economy. Broadly speaking, large firms and joint-stock companies were made possible by two phases of accounting advances. The first phase, double-entry bookkeeping, was developed for the trading banks and “super companies” of early fourteenth century Italy. The second phase were accounting and reporting techniques developed for the larger joint stock companies of the Netherlands and England, starting with the India companies in the seventeenth century.

Accounting allowed manager-owners to keep track of employees and (in the second phase) for non-management owners to keep track of managers. These accounting techniques, along with the rise of literacy and numeracy among the workers, provided a new way for tax collectors to measure value. Once these larger companies came to handle a sufficient fraction of an jurisdiction’s value of transactions, it was rational for governments to take advantage of their measurement techniques, and they did so — the result being the most lucrative tax scheme ever, the income tax.

Nazgulnarsil, a commenter, points out that whether or not a society that is taxing below the optimum can survive would seem to depend on the relative costs of offense and defense:

Thus when defense is cheap relative to offense we can expect freer societies since they can afford not to tax at the optimum rate for military expenditures.

Nick goes further:

Nazgulnarsil, since the optimal point for economic growth or wealth is at a tax rate well below the Laffer optimum, one could derive as a corollary that societies with better natural defenses, and thus lower defense costs (in the days before the welfare state) would have higher economic growth (or higher population growth in the Malthusian era before the industrial revolution) per acre of arable land, and perhaps other desirable characteristics as well, such as a more libertarian legal system, and that such societies will be more more likely to conquer than be conquered.

There seems to be some geographical evidence for this: countries with natural barriers of sea or mountain tended to create empires rather than be ruled under them, and tended to have better legal systems and more economic prosperity.

How Jerry Murrell Started Five Guys

Wednesday, April 14th, 2010

Jerry Murrell explains how he created Five Guys Burgers and Fries — perhaps the closest thing the Atlantic coast has to In-In-Out:

My parents died my last year in college. I married, had three kids, divorced, then remarried. I moved to northern Virginia and was selling stocks and bonds. My two eldest sons, Matt and Jim, said they did not want to go to college. I supported them 100 percent.

Instead, we used their college tuition to open a burger joint. Ocean City had 50 places selling boardwalk fries, but only one place always has a 150-foot line — Thrashers. They serve nothing but fries, but they cook them right — high-quality potato, peanut oil. That impressed me. I thought a good hamburger-and-fry place could make it, so we started with a takeout shop in Arlington, Virginia.

Our lawyer said, “You need a name.” I had four sons — Matt, Jim, Chad are from my first marriage, and Ben from my second to Janie, who has run our books from Day One. So I said, “How about Five Guys?” Then we had Tyler, our youngest son, so I’m out! Matt and Jim travel the country visiting stores, Chad oversees training, Ben selects the franchisees, and Tyler runs the bakery.

Three days before we opened, I was still working as a trader in stocks and bonds and was in a hotel for a meeting in Pittsburgh. I found a book in the nightstand, next to the Bible, about JW Marriott — he had an A&W stand that he converted and built into the Hot Shoppes chain. He said, Anyone can make money in the food business as long as you have a good product, reasonable price, and a clean place. That made sense to me.

We figure our best salesman is our customer. Treat that person right, he’ll walk out the door and sell for you. From the beginning, I wanted people to know that we put all our money into the food. That’s why the décor is so simple — red and white tiles. We don’t spend our money on décor. Or on guys in chicken suits. But we’ll go overboard on food.

Most of our potatoes come from Idaho — about 8 percent of the Idaho baking potato crop. We try to get our potatoes grown north of the 42nd parallel, which is a pain in the neck. Potatoes are like oak trees — the slower they grow, the more solid they are. We like northern potatoes, because they grow in the daytime when it is warm, but then they stop at night when it cools down. It would be a lot easier and cheaper if we got a California or Florida potato.

Most fast-food restaurants serve dehydrated frozen fries — that’s because if there’s water in the potato, it splashes when it hits the oil. We actually soak our fries in water. When we prefry them, the water boils, forcing steam out of the fry, and a seal is formed so that when they get fried a second time, they don’t absorb any oil — and they’re not greasy.

The magic to our hamburgers is quality control. We toast our buns on a grill — a bun toaster is faster, cheaper, and toasts more evenly, but it doesn’t give you that caramelized taste. Our beef is 80 percent lean, never frozen, and our plants are so clean, you could eat off the floor. The burgers are made to order — you can choose from 17 toppings. That’s why we can’t do drive-throughs — it takes too long. We had a sign: “If you’re in a hurry, there are a lot of really good hamburger places within a short distance from here.” People thought I was nuts. But the customers appreciated it.

What Five Guys lacks is the high level of customer service delivered by In-N-Out’s high-quality employees. Chick-fil-A has that — but no burgers.

Arcade Game Propaganda Posters

Wednesday, April 14th, 2010

Steve Thomas has produced a number of arcade game propaganda posters.

Three Drug-Delivery Breakthroughs

Wednesday, April 14th, 2010

Jay Cornell shares three drug-delivery breakthroughs that may minimize dosages, maximize benefits, and avoid side-effects:

Dr. Hanadi Sleiman and his team at the McGill University Chemistry Department have invented a new method for using DNA to create nanotubes of any shape that can encapsulate drugs or other cargo. The nanotubes can be porous or closed and then, by the addition of a specific DNA strand, triggered to open and release their contents.

Bacteria (and other microorganisms) often adhere to surfaces and form tough, self-protective biofilms. Existing antibiotics often have difficulty penetrating them, especially in the case of antibiotic-resistant bacteria such as MRSA. Dr. Christian Melander and his team at North Carolina State University have discovered an effective new weapon for the fight. By pretreating the bacteria with a 2-aminoimidazole compound, penicillin became 128 times more effective, even against penicillin-resistant bacteria. Biofilm dispersal was 1,000 times more effective.

Magnets have been in the bags of quacks for generations, but sometimes real doctors find a good use for them. Ke Cheng, Tao-Sheng Li, Konstantinos Malliaras, Darryl Davis, Yiqiang Zhang, and Eduardo Marbán of Cedars-Sinai Medical Center in Los Angeles are using magnets to improve stem cell therapy for heart disease. Normally many of the injected cells are washed away by blood flow and don’t make it to (or stay in) the area of the heart where they are needed. Their solution: load the stem cells with tiny iron particles, then place a toy magnet externally, close to the damaged part of the heart. Experiments with rats showed that three times as many cells stayed in the heart, and healing improved.