Drug mitigates toxic effects of radiation in mice

Friday, July 16th, 2010

Investigators at the University of North Carolina (UNC) Lineberger Comprehensive Cancer Center have found an oral drug that mitigates the toxic effects of radiation in mice by inhibiting enzymes involved in cell division:

Several decades of work have shown that cells which are not dividing are resistant to agents that damage DNA, like radiation. Workers in the Sharpless lab were then able to show that the induction of PQ [Pharmacological Quiescence, the drug-induced cessation of cell-division] immediately before or up to 20 hours after radiation exposure were able to protect mice from a lethal dose of radiation. PQ protected all the normal cells of blood, including platelets, red cells and white cells.

(Hat tip to Nyrath.)

Responsibility has been completely severed from authority

Thursday, July 15th, 2010

A few years ago, Mencius Moldbug recommended Richard Crossman’s diaries, which were the inspiration for the BBC series Yes, Minister, as an unbeatable introduction to the reality of modern government — the reality being that the bureaucrats are in charge.

Foseti, who’s living the dream as a bureaucrat in Washington, explains the process for firing a government employee:

I’ve done a bit of asking around and found one person who works in government who is familiar with a federal employee actually being fired.

A bit of background. Apparently the fired person did nothing. The conservative estimate was that this guy did 10-20 hours of work in a year. (They swear up and down that he did no more than this). He did, however, consistently show up to work. For years, his supervisors basically ignored him. Then, he got a new supervisor who decided that enough was enough. So, the supervisor began the firing process.

First, the supervisor has to do document that the employee does not do or is incapable of performing his job functions. In this case, the supervisor documented requests to the employee and the employee’s response or lack thereof. This part of the process took several months.

Then the employee has to be flunked at a couple performance reviews. Another year down the drain. This flunking kicks off the official process.

Finally, the official process includes the employee enlisting the help of a union representative. It ends with full-on review by some sort of board.

My understanding is that this process took longer than one year. Further, during much of the union review, the process took up a huge amount of the supervisor’s time. So, firing multiple employees would take years and (with multiple employees) it would require 100% of the supervisor’s time during a significant portion of the union review process.

Before concluding, I should point out that the supervisor gets no reward for firing a bad employee. In fact, a supervisor’s budget may be cut, since the supervisor now has one less staff member. Good employees may choose to avoid that particular supervisor as well. There is no upside to firing an employee as far as I can tell. The amount of time and energy it costs a supervisor is downside enough to dissuade almost any sane supervisor from firing anyone.

I find this darkly amusing:

Also note that the fact that the process is so slow means that it’s basically impossible for the head of an agency to fire anyone. If an appointment at the head of an agency lasts for 4 years, the process would not be concluded by the time the head’s term had expired.

The root of the problem, Foseti continues, is that responsibility has been completely severed from authority:

Finally, it’s not always clear that “political heat” is bad for federal employees. Want to guess whether average salaries at healthcare agencies will go up or down after passage of healthcare reform? Care to make the same guess for the financial agencies after the financial crisis? Congress even protects employees of federal agencies that are being eliminated.

As Devin Finbarr adds, the feedback system might actively select for sadism and misrule:

If a bureaucracy screws an area up, more resources must be dedicated to fix the problem. This will result in more power for that bureaucracy, and because their is no firing or reorgs, more power for the people who screwed up in the first place.

The Incentive Taboo

Thursday, July 15th, 2010

Eric Falkenstein notes that the following quotes are considered patently idiotic by TalkingPointsMemo:

“I’ve literally had construction companies tell me, ‘I can’t get people to come back to work until…they say, I’ll come back to work when unemployment runs out.’”
—Pennsylvania Attorney General Tom Corbett

“As bad as it sounds, ultimately we do have to sometimes accept a wage that’s less than we had at our previous job in order to get back to work and allow the economy to get started again. Nobody likes that, but it may be one of the tough love things that has to happen.”
—Rand Paul, Republican nominee for senator of Kentucky

“[C]ontinuing to pay people unemployment compensation is a disincentive for them to seek new work.”
—Sen. Jon Kyl (R-AZ)

“[It's] facilitating the problem if you give an animal or a person ample food supply,” he said. “They will reproduce, especially ones that don’t think too much further than that. And so what you’ve got to do is you’ve got to curtail that type of behavior. They don’t know any better.”
—South Carolina Lt. Gov. Andre Bauer

You’re just not supposed to say that incentives matter; it’s taboo.

My question is this: What is the rationale for making unemployment benefits a grant and not a loan?

Addendum: Unemployment benefits are nominally insurance payouts — but I can’t imagine too many insurance companies structuring a policy to be so susceptible to moral hazard.

If the goal is to get people through a rough patch, why give them money outright, when we could help more people, more efficiently, by loaning them (more) money?

Sawdust Cannon

Thursday, July 15th, 2010

When I first saw the title — sawdust cannon — I was expecting them to use a grain silo-style explosion to propel a cannon ball.

As much as I enjoyed the giant fireball, I have to recommend against igniting pillars of flame in a wooded glen.

(Hat tip to Borepatch.)

A Chance to Flex Their Moral Muscles

Thursday, July 15th, 2010

Edward Banfield explains how reasonable policy suggestions get dismissed as unacceptable, even repellent, because they do not seem morally improving:

It does not appear to be improving to a youth to send him to work rather than to school, especially as this is what is in one’s interest as a taxpayer to do. It does not appear to be improving to a recidivist to keep him in jail pending trial, especially as this is what accords with one’s feelings of hostility toward him. It does not appear to be improving to a slum dweller to say that if he has an adequate income but prefers to spend it for things other than housing he must not expect the public to intervene, especially as it is in one’s “selfish” interest that the public not intervene.

In reality, the doing of good is not so much for the benefit of those to whom the good is done as it is for that of the doers, whose moral faculties are activated and invigorated by the doing of it, and for that of the community, the shared values of which are ritually asserted and vindicated by the doing of it.

For this reason, good done otherwise than by intention, especially good done in pursuance of ends that are selfish or even “nontuistic,” is not really “good” at all. For this reason, too, actions taken from good motives count as good even when in fact they do harm.

By far the most effective way of helping the poor is to keep profit-seekers competing vigorously for their trade as consumers and for their services as workers; this, however, is not a way of helping that affords members of the upper classes the chance to flex their moral muscles or the community the chance to dramatize its commitment to the values that hold it together. The way to do these things is with a War on Poverty; even if the War should turn out to have precious little effect on the incomes of the poor — indeed, even if it should lower their incomes — the undertaking would nevertheless represent a sort of secular religious revival that affords the altruistic classes opportunities to bear witness to the cultural ideal and, by doing so, to strengthen society’s adherence to it.

One recalls Macaulay’s remark about the attitude of the English Puritans toward bear-baiting: that they opposed it not for the suffering that it caused the bear but for the pleasure that it gave the spectators.

Perhaps it is not far-fetched to say that the present-day outlook is similar: the reformer wants to improve the situation of the poor, the black, the slum dweller, and so on, not so much to make them better off materially as to make himself and the whole society better off morally.

(From The Unheavenly City Revisited.)

Medical Literacy

Thursday, July 15th, 2010

Medical literacy is rare:

Materials that accompany common pediatric drugs exceed most parents’ reading levels, according to a study in Academic Pediatrics.

Researchers filled identical prescriptions for two common pediatric medications — prednisolone (an anti-inflammatory steroid) and amoxicillin (an antibiotic) — at 20 pharmacies in Colorado, Georgia and Tennessee. Seventeen of the pharmacies provided written material along with the medications.

The researchers rated the difficulty of reading this material using two tests: the Flesch-Kincaid formula, which counts the average words per sentence and average syllables per word; and McLaughlin’s Simplified Measure of Gobbledygook, which focuses on the number of words with three or more syllables.

According to these formulas, the materials were written at an average grade level of around 9.6 or 11.2, respectively. At least 85% of parents nationwide would have trouble deciphering language of this complexity, “since less than 15% of parents nationwide read at or above a high school level,” a recent study said.

Is it ironic that the title of that study is Evaluation of Consumer Medical Information and Oral Liquid Measuring Devices Accompanying Pediatric Prescriptions?

What conclusion are we supposed to draw from the statistic that less than 15% of parents nationwide read at or above a high school level? (The high school graduation rate is over 70 percent.)

Dad Life

Wednesday, July 14th, 2010

I’m guessing this wouldn’t have been nearly as funny to me a decade ago — like Dilbert when I was still in college:

(Hat tip to Buckethead.)

How Microbes Defend and Define Us

Wednesday, July 14th, 2010

If you’re squeamish, you may not want to dig into the details of bacteriotherapy:

In 2008, Dr. Khoruts, a gastroenterologist at the University of Minnesota, took on a patient suffering from a vicious gut infection of Clostridium difficile. She was crippled by constant diarrhea, which had left her in a wheelchair wearing diapers. Dr. Khoruts treated her with an assortment of antibiotics, but nothing could stop the bacteria. His patient was wasting away, losing 60 pounds over the course of eight months. “She was just dwindling down the drain, and she probably would have died,” Dr. Khoruts said.

Dr. Khoruts decided his patient needed a transplant. But he didn’t give her a piece of someone else’s intestines, or a stomach, or any other organ. Instead, he gave her some of her husband’s bacteria.

Dr. Khoruts mixed a small sample of her husband’s stool with saline solution and delivered it into her colon. Writing in the Journal of Clinical Gastroenterology last month, Dr. Khoruts and his colleagues reported that her diarrhea vanished in a day. Her Clostridium difficile infection disappeared as well and has not returned since.

The procedure — known as bacteriotherapy or fecal transplantation — had been carried out a few times over the past few decades. But Dr. Khoruts and his colleagues were able to do something previous doctors could not: they took a genetic survey of the bacteria in her intestines before and after the transplant.

Before the transplant, they found, her gut flora was in a desperate state. “The normal bacteria just didn’t exist in her,” said Dr. Khoruts. “She was colonized by all sorts of misfits.”

Two weeks after the transplant, the scientists analyzed the microbes again. Her husband’s microbes had taken over. “That community was able to function and cure her disease in a matter of days,” said Janet Jansson, a microbial ecologist at Lawrence Berkeley National Laboratory and a co-author of the paper. “I didn’t expect it to work. The project blew me away.”

(Hat tip to Aretae.)

Katrina’s Silver Lining

Wednesday, July 14th, 2010

New Orleans had one of the worst performing public school districts in the nation — until Katrina:

Of the children entering kindergarten in New Orleans, virtually none knew their letters. The charter schools expect to turn that around:

“They say no matter how poor you are, no matter who you is or where you come from, you can go to college.”

North Dakotan Monarchist

Wednesday, July 14th, 2010

Hilaire du Berrier explains how a boy from North Dakota became a monarchist:

When I was 9 years old I was given a book on Napoleon’s cavalry, and my mind was made up. One of the first things I did when I came to Paris was to join the French monarchist party.

I think that one of the most sublime speeches a head of state ever made was the reply that King Alphonso XIII gave to the men from Madrid who came to ask him to abdicate. His Majesty was in the Maurice Hotel in Paris, heard them through and when they were finished he stood up, addressed them and said: “You have asked me to abdicate. But abdicate I cannot. For I am not only the King of Spain, but I am the King of all the Spaniards. And I not only have my own reign, but those of my family who have gone before me, for which I must someday give a rigorous accounting.”

I was walking in the Rue de Rivioli one day, and there was a tall man approaching. I recognized him, and I tipped my hat. He tipped his hat. It was Alphonso. After that I would have followed him anywhere.
[...]
Did you ever read [Oswald] Spengler? He put it this way: “Tradition is cosmic force at its highest energy.” And he said, “Modern man rejects everything he does not understand and destroys with an epigram institutions reared by the inarticulate wisdom of the centuries.”

Turbo-Electric Hybrids

Wednesday, July 14th, 2010

A series-hybrid, or Range-Extended Electric Vehicle (REEV), like the Chevy Volt, uses electric motors — which have a high power-to-weight ratio and provide adequate torque over a wide range of speeds — to spin the wheels.

The hybrid’s internal combustion engine isn’t connected to the wheels by a heavy transmission. It simply runs a generator and then sends the generated electricity to the electric motors, which turn the wheels. The only transmission is electric.

This isn’t a new idea. So-called Diesel locomotives are actually Diesel-electric locomotives. Eliminating the mechanical transmission is especially helpful when you have four or more axles, and you need dozens of different gears to keep the engine within its power band.

What a modern hybrid adds is significant battery storage between the generator and the motors, so the engine can always run at its optimal speed, either storing extra energy in the batteries or drawing some off, as demand fluctuates. But even this isn’t new; pre-nuclear diesel submarines used their engines to charge batteries while on the surface and ran all-electric when submerged without air.

Of course, once you’ve switched to electric motors, you’re no longer tied to any one kind of generator, and you may decide to switch away from a conventional, reciprocating, piston engine to a gas turbine engine, which has its own strengths and weaknesses:

Advantages of gas turbine engines

  • Very high power-to-weight ratio, compared to reciprocating engines;
  • Smaller than most reciprocating engines of the same power rating.
  • Moves in one direction only, with far less vibration than a reciprocating engine.
  • Fewer moving parts than reciprocating engines.
  • Low operating pressures.
  • High operation speeds.
  • Low lubricating oil cost and consumption.

Disadvantages of gas turbine engines

  • Cost
  • Less efficient than reciprocating engines at idle
  • Longer startup than reciprocating engines
  • Less responsive to changes in power demand compared to reciprocating engines

Those disadvantages are significant in a passenger road vehicle — as Chrysler found out — until you disconnect the turbine from the wheels and switch to a turbo-electric hybrid, with batteries to buffer power demand.

GM apparently did just that, if only briefly, in 1999, with an experimental version of its EV1, which used a 100-kg (220-lb) gas turbine to deliver 40 kW of electrical power, enough to achieve speeds up to 80 mph (128.8 km/h) and to return the car’s 44 NiMH cells to a 50% charge level:

A fuel tank capacity of 6.5 US gal (24.6 L; 5.4 imp gal) and fuel economy of 60 mpg-US (3.9 L/100 km; 72 mpg-imp) to 100 mpg-US (2.4 L/100 km; 120 mpg-imp) in hybrid mode, depending on the driving conditions, allowed for a highway range of more than 390 miles (627.6 km). The car accelerated to 0-60 mph (96.6 km/h) in 9 seconds.

Now Capstone Turbine Corporation is putting its MicroTurbines in hybrid electric buses, trolleys, and supercars:

The CMT-380 plug-in hybrid is powered by lithium-polymer batteries that can be charged at home or at public recharging stations. The car can operate on battery power alone for up to 80 miles. Then, when batteries reach a predetermined state of discharge, the Capstone C30 microturbine starts up to recharge the batteries and extend driving range up to 500 miles. The C-30 provides 30 kW of electric power and can run on a variety of fuels including natural gas, landfill gas, biodiesel, diesel, kerosene, and propane.

Interestingly, the CMT-380 was developed by Richard Hilleman, Chief Creative Director at video game producer Electronic Arts, with support from Capstone Turbine. The series hybrid system is installed in a Factory Five Racing GTM body and chassis that’s normally powered by a Chevy Corvette V-8. The result is a supercar with a 0-60 mph acceleration time of 3.9 seconds and 150 mph top speed.

The CMT-380′s microturbine features an electric generator and turbine components mounted on a single shaft supported by air bearings. Capstone microturbines operate at extremely high speeds of up to 96,000 rpm, resulting in a very high power-to-weight ratio. No liquids are needed to lubricate or cool the microturbine so little maintenance is required.

While this microturbine hybrid was developed primarily to showcase the potential of microturbines in hybrid range extender applications, substantial interest has prompted the company to plan for the production of a limited number of these high-tech supercars for discerning customers. No price has been identified.

A Small Clean Hole

Wednesday, July 14th, 2010

Concerned soldiers in the modern US Army have complained that the M4 carbine is less effective than it should be at 500 meters. That is, at long ranges, shot from a short barrel, the glorified .22 leaves a tiny hole. (At closer ranges, or from a longer barrel, it shatters bone.)

A century ago, Theodore Roosevelt was saying the same thing about the new 7 mm Mauser rifle the Spaniards were using — it left a small clean hole:

Thomas Isbell, a half-breed Cherokee in the squad under Hamilton Fish, was among the first to shoot and be shot at. He was wounded no less than seven times. The first wound was received by him two minutes after he had fired his first shot, the bullet going through his neck. The second hit him in the left thumb. The third struck near his right hip, passing entirely through the body. The fourth bullet (which was apparently from a Remington and not from a Mauser) went into his neck and lodged against the bone, being afterward cut out. The fifth bullet again hit his left hand. The sixth scraped his head and the seventh his neck. He did not receive all of the wounds at the same time, over half an hour elapsing between the first and the last. Up to receiving the last wound he had declined to leave the firing-line, but by that time he had lost so much blood that he had to be sent to the rear. The man’s wiry toughness was as notable as his courage.
[...]
The Mauser bullets themselves made a small clean hole, with the result that the wound healed in a most astonishing manner. One or two of our men who were shot in the head had the skull blown open, but elsewhere the wounds from the minute steel-coated bullet, with its very high velocity, were certainly nothing like as serious as those made by the old large-calibre, low-power rifle. If a man was shot through the heart, spine, or brain he was, of course, killed instantly; but very few of the wounded died — even under the appalling conditions which prevailed, owing to the lack of attendance and supplies in the field-hospitals with the army.

A typical Mauser 7 mm bullet weighs 162 grains (10.5 g) and leaves the muzzle at 2,600 feet per second (800 m/s), with 2,480 foot-pounds (3,360 J) of energy.

A 5.56 mm bullet weighs just 62 grains (4 g) but leaves the muzzle (of an M16) at 3,100 feet per second (940 m/s) — for 1,303 foot-pounds (1,767 J) of energy. And the tiny bullet loses energy quickly.

The Mauser 7 mm could make its characteristic small clean hole in a large muddy beast, too:

The ballistics of the 7x57mm became popular with deer and plains game hunters. The relatively flat trajectory and manageable recoil ensured its place as a sportsman’s cartridge. The 7x57mm can offer very good penetrating ability due to a fast twist rate that enables it to fire long, heavy bullets with a high sectional density.

This made it popular in Africa, where it was used on animals up to and including elephants, for which it was particularly favored by noted ivory hunter W. D. M. Bell, who shot 1,011 elephants using a 7x57mm rifle, when most ivory hunters were using larger-caliber rifles. Bell selected the cartridge for moderate recoil, and used 11-gram military full metal jacket bullets for reliable penetration. Bell sectioned an elephant skull to determine the size and location of the brain, and used careful aim to ensure bullet placement in the brain.

Suburban Poverty

Wednesday, July 14th, 2010

I’ve been discussing urban issues lately, and commenter Ross noted that, according to the Brookings Institute poverty is increasingly suburban, not rural or urban:

Judging from the report, the absolute per capita poverty is still greater in the cities, but both the rate of increase and the total amount is significantly greater in suburbia. Perhaps the cities have “maxed out” and adapted to their poverty carrying capacity, and the suburbs are now playing catch-up? Interesting implications.

The best graphics and tables are here.

In fact, I mentioned the same idea a couple years ago. Part of the problem is that suburbs don’t mature gracefully:

Sprawling, large-lot suburbs become less attractive as they become more densely built, but urban areas — especially those well served by public transit — become more appealing as they are filled in and built up. Crowded sidewalks tend to be safe and lively, and bigger crowds can support more shops, restaurants, art galleries.

Three Attitudes Toward Government

Tuesday, July 13th, 2010

Mencius Moldbug wrote a letter to a liberal friend who had sent him a link to J.M. Bernstein’s NY Times opinion piece on the very angry tea party:

If I had to describe it in a sentence, I would say that the rage is easily explained, but not easily explained in the terms of those who feel it. They are clearly angry about something, but the actual words that come out of their mouths are often nonsensical and contradictory. This is why it is so hard for so many to get a handle on. It is simply inarticulate demotic discontent.

Basically, you will see this in any hieratic system of government which the peasants do not really understand. They feel, somehow, that they are getting jobbed. They are (in my opinion) getting jobbed. But how they are getting jobbed is infinitely more complicated than their simple peasant mind can understand. (Also, the idea that they are in some way jobbing the peasants is the farthest possible concept from the collective mind of the gentlemen.)

Therefore, the peasants open their mouths and out comes rage and nonsense. As a gentleman, you are fascinated and repelled by this extraordinary wave of rage and nonsense. Do I have this reaction right? You may of course feel free to disregard the crude metaphor of medieval class conflict, which is no more than a metaphor. Still, I feel it is a good way to ground the conversation in history.

One easy reaction is to blame Fox News. It is true: for the first time in a long time, the peasants have an exclusively peasant-themed mass propaganda channel. However, the objective observer notes quickly that Fox News is not so much telling its audience what to think, as telling them they are allowed to think what they already think. Since they are peasants, lacking any semblance of an aristocratic culture that can accumulate and transmit collective wisdom across generations, what they think is generally nonsense.

Fox News aggregates and retransmits this nonsense, but does not really direct it much in Goebbels style. In some ways it even moderates it — for instance, Fox, and neocons in general, are not much less aggressive in purging racism than establishment journalists.
[...]
But, although they do not reason openly and explicitly in this existential manner, the tea partiers feel emotionally that their entire system of government has lost, over the course of decades, their confidence, and needs to be replaced by something entirely different. The basic problem with their rhetoric is that in place of “something entirely different,” they insert two-dimensional cliches of historical American nationalism, dimly remembered at a folk level from the 1920s. It was no less nonsense then, but at least it had an aristocratic leadership caste, which was actually capable of governing a country. In short, it had Calvin Coolidge. Sarah Palin is no Calvin Coolidge.

There are three basic attitudes toward government in America today:

There are people who believe government is there to serve them; there are people who believe government is there to serve others; there are people who believe government is there to subsidize them. In our medieval metaphor, these correspond to peasants, gentlemen, and varlets respectively. The last is the caste Marx called the “lumpenproletariat” — and he was no fan of this group, or of political movements that exploited it. Respectable people say “underclass.”

When gentlemen look at progressivism, they see a movement whose purpose is to help the underclass, those whose plight is no fault of their own. When peasants look at progressivism, they see a movement whose purpose is to employ gentlemen in the business of public policy, by using the peasants’ money to buy votes from varlets. Who, in the peasants’ perception, abuse the patience and generosity of both peasants and gentlemen in almost every imaginable way, and are constantly caressed by every imaginable authority for doing so.

Among gentlemen, the idea that government could be there to serve us is almost socially taboo.
[...]
Peasants see a patron-client relationship between the gentlemen and the varlets — a relationship not at all unlike the late Roman relationship of clientela, where a patrician measured his social status by the vast army of plebeians that battened on his trenches. Again, what to the gentleman appears as a noble act of charity, compassion, etc, to the coarse and cynical peasant reveals itself as a purchase of political power, with his tax dollars if not his physical safety. Therefore a vision of the gallows arises in his hindbrain.

Can both be correct? Of course they can. Every case, in every detail, is different, and every case can be viewed from both perspectives. As Solzhenitsyn said, the line between good and evil runs through every human heart.

And again — are the tea partiers thinking this story? No such elaborate historio-political fantasy has ever come anywhere close to their heads. But it is, I would argue, the reality of history in our time. Truth, even if not realized in totum, glints off every surface. Therefore, it is an emotional subtext that spawns a continuous stream of inchoate, inarticulate and inexplicable rage. Precisely as your New School prof observes!

Fancy Shavers Leave Some Men Feeling Nicked

Tuesday, July 13th, 2010

The Wall Street Journal reports that men are hoarding old-model razors, because they’re tired of the endless “upgrades” that don’t provide a better shave:

Steven Schimmel, owner of Pasteur Pharmacy in Manhattan, says he quadrupled sales in his shaving aisle by carrying hard-to-find products like British shave creams, badger-hair brushes and safety razors. He sells eight brands of double-edge blades, including Gillette’s 7 O’Clock blades, bought from a dealer in India.

While the latest advances in shaving remain big sellers on Drugstore.com Inc., unit sales of hard-to-find blades including the Schick Injector and Wilkinson Sword increased in 2009 over the year before. Drugstore.com regularly lobbies blade-makers to maintain their inventories.

Shaving is big business:

Gillette brings in more than $4 billion in annual sales; Schick sees sales of around $1 billion a year, according to analysts’ estimates. Though the recession hurt sales of blades and boosted sales of cheaper disposable razors, the two companies still have a lock on the U.S. market. Gillette commands 70% of the razors-and-blades category, and Schick holds about 10%, according to market-data firm Euromonitor International Inc.