Study Shows Why the Flu Likes Winter

Thursday, December 6th, 2007

Study Shows Why the Flu Likes Winter:

Reading a paper published in 1919 in the Journal of the American Medical Association on the flu epidemic at Camp Cody in New Mexico, he came upon a key passage: “It is interesting to note that very soon after the epidemic of influenza reached this camp, our laboratory guinea pigs began to die.” At first, the study’s authors wrote, they thought the animals had died from food poisoning. But, they continued, “a necropsy on a dead pig revealed unmistakable signs of pneumonia.”

Dr. Palese bought some guinea pigs and exposed them to the flu virus. Just as the paper suggested, they got the flu and spread it among themselves. So Dr. Palese and his colleagues began their experiments.

By varying air temperature and humidity in the guinea pigs’ quarters, they discovered that transmission was excellent at 41 degrees. It declined as the temperature rose until, by 86 degrees, the virus was not transmitted at all.

The virus was transmitted best at a low humidity, 20 percent, and not transmitted at all when the humidity reached 80 percent.

The animals also released viruses nearly two days longer at 41 degrees than at a typical room temperature of 68 degrees.

Flu viruses spread through the air, unlike cold viruses, Dr. Palese said, which primarily spread by direct contact when people touch surfaces that had been touched by someone with a cold or shake hands with someone who is infected, for example.

Flu viruses are more stable in cold air, and low humidity also helps the virus particles remain in the air. That is because the viruses float in the air in little respiratory droplets, Dr. Palese said. When the air is humid, those droplets pick up water, grow larger and fall to the ground.

A Liquor of Legend Makes a Comeback

Thursday, December 6th, 2007

A Liquor of Legend Makes a Comeback:

Since the start of the year, at least four absinthes, including two from Europe and one from South America, have been cleared for sale. At the same time, hundred-year-old legends about its ties to murder and madness have been discredited. For years, absinthe’s chief appeal has been its shady reputation and contraband status. It was said to have caused artists like Van Gogh to hallucinate. Now that it is safe and legal, will anyone still drink it?

To find out, I tried the two absinthes on sale in New York along with an early sample of St. George Absinthe Verte. And I was astonished by how delicate, gentle and refreshing they were. Astonished in part because of my earlier run-ins with absinthe. There was the Portuguese stuff that looked like radiator fluid and tasted like a mouthful of copper. There was the Czech product that a friend smuggled past customs in a mouthwash bottle. I would have preferred the mouthwash.

Another European brand is “the color of reactor cooling fluid and there’s nothing natural about that,” said Mr. Winters, who would know. Before turning to alcohol as a full-time job, he worked as an engineer on a reactor on board a nuclear-powered aircraft carrier.

Absinthe aficionados agree that a lot of absinthe isn’t very good.

Here’s how real absinthe is made:

After a few tries, Mr. Winters found that grand wormwood was best used in just the first step of absinthe making, when it is infused into grape brandy along with anise and fennel and then distilled, so its bitterness could be left behind in the still. In the second step, he infused a portion of what came out of the still with lemon balm, hyssop, tarragon and other botanicals, including a much less bitter cousin of grand wormwood. Finally this flavorful infusion is mixed back into the result of the first distillation.

So, how did absinthe become illegal and then legal again?

Absinthe was banned in America in 1912 because of health concerns fanned by some of the same anti-alcohol forces who would later push through Prohibition. Due to a reorganization of the government’s food-safety bureaucracy, the ban was effectively lifted before World War II, although it took decades before anybody realized it.

Co-ed Combat

Thursday, December 6th, 2007

I have not been reading the Volokh Conspiracy, but Megan McArdle (née Jane Galt) recently expressed shock over something that came up in a guest-blog by Kingsley Browne, whose new book, Co-ed Combat, argues that women should not fight our nation’s wars.

Browne notes that “advocates of integration of women into combat forces often downplay the sex difference in physical capacity,” then goes on to examine the evidence. Megan’s response:

Is this actually an argument made by large numbers of people? Because it’s completely, obviously insane. Being on the tail end of the size distribution, this realization was perhaps delayed slightly for me — but not past the age of sixteen, when I playfully snatched a hat from the head of a male companion who was a year younger and five inches shorter than I was, only to have him calmly and without visible effort use one hand to pin my arms behind my back while with the other he retrieved his chapeau. I’m both (very) large and strong for my gender, and yet I’m not sure I’ve ever met a (healthy) man who wasn’t stronger than me; even the 130 pound scarecrows I’ve dated were clearly my superiors in physical strength.

Since I’ve seen that exact argument come up numerous times — and I’ve seen the holders of that belief ignore both the evidence of daily life and of quantitative scientific studies — I don’t see it as any kind of silly straw man at all. (Straw person? Person of strawness?)

Browne summons a lot of evidence for the physical differences between the sexes:

Advocates of integration of women into combat forces often downplay the sex difference in physical capacity, correctly pointing out that some women are stronger than some men. In fact, however, there is little overlap between the sexes in terms of strength.

Women, on average, have only one-half to two-thirds the upper-body strength of men. The probability that a randomly selected man will have greater upper-body strength than a randomly selected woman is generally between 95 and 99 percent, depending upon the measure and the sample. Most of this difference is due to differences in the quantity of muscle tissue, a difference attributable primarily to sex hormones.

Although most discussion of physical sex differences focuses on strength, the sexes also differ on a host of other performance measures, such as running speed, aerobic and anaerobic capacity, endurance, and throwing speed and accuracy. These abilities are all potentially important in combat.

Some assert that these large physical differences can be overcome through training. In fact, however, training often increases the sex difference. Both sexes benefit from strength training, and in samples of out-of-shape individuals, women may initially gain more from training than men. Nonetheless, the overlap between the sexes decreases, because training not only increases the strength of both groups, it also decreases the variability within the groups. When males and females both start out in good physical condition, women gain less from further conditioning than men do, so the gap between the sexes actually increases.

Related to differences in strength and bone mass is the high rate of injuries, especially stress fractures, suffered by women in physical training. An extensive study of physical capacity by the British Ministry of Defence concluded that only about 0.1 percent of female recruits and 1 percent of trained female soldiers could satisfy the required physical standards for infantry and armor without sustaining substantially higher rates of injuries than men.

These physical differences still matter:

Modern ground combat still requires substantial physical strength. Today’s infantry soldier often carries between 75 and 100 pounds, and sometimes more. Just his rifle, ammunition, helmet, and body armor can weigh 60 pounds. Add to that food, water, night-vision goggles, various other electronic gear (and the batteries for it), and pretty soon the soldier is carrying a very heavy load — indeed, heavier than that of the soldier of World War II.

After carrying this heavy load, soldiers often must dig in to hard ground for shelter, perhaps in 120-degree heat. If there is concern about chemical or biological agents, as at the outset of the Iraq war, soldiers may have to wear stifling protective gear, which imposes greater physiological stress on women than on men.
[...]
Many combat-support positions also require physical strength. A study conducted in the 1980s found that all Army men in heavy-lifting Military Occupational Specialties (MOSs) were qualified for their jobs, but only about 15 percent of women were. The military has been reluctant to impose strength requirements widely, however, and even if realistic standards were set for particular jobs, adverse conditions often interfere with the neat system of MOSs. “It’s not in my job description” is not a permissible response in a firefight.
[...]
Similarly, if a ship gets struck by a bomb, missile, or mine, all hands may have to turn to the tasks of damage control, such as fire fighting, flood limitation, and evacuation of the wounded. In 1988, after the guided-missile frigate USS Samuel B. Roberts struck an Iranian mine in the Persian Gulf, it came closer than any other U.S. ship since the Korean War to be sunk due to hostile action. Sailors of all specialties turned to fighting the resulting fire and flooding.

Because the captain of the Roberts was concerned that shells would “cook off,” he ordered one of the magazines cleared of ammunition. A “bucket brigade” of fifty sailors — twenty percent of the ship’s crew — passed the fifty-pound shells from man to man. Although the regular job duties of many of these sailors did not require heavy lifting, if the sailors had been unable to perform when necessary, the Roberts would almost certainly have sunk. Yet a Navy study found that almost all Navy women fail the physical standards for critical damage-control tasks, while virtually all men pass.

Browne also has much to say about the psychological differences between the sexes, which he says are milder, with more overlap, but still significant:

RISK PREFERENCE: From toddlerhood on, males have a greater preference than females for risk – especially, but not only, physical risk – a fact reflected in the substantially higher rate of accidental death among boys worldwide and the roughly twelve-fold sex difference in workplace deaths among adults in the U.S. A meta-analysis of 150 risk-taking studies covering subjects of all ages concluded that “males took risks even when it was clear that it was a bad idea,” while females “seemed to be disinclined to take risks even in fairly innocuous situations or when it was a good idea.”

FEAR LEVELS: Risk-taking and fear are intimately related, and females from infancy experience greater fear than males. Sex differences in fear and risk-perception have two components. Women are more likely to perceive risk in a situation than men are, and even when the sexes perceive the same level of risk, women have higher levels of fear.

Psychologist Anne Campbell has argued that sex differences in fear and risk-taking are a consequence of differences in selective pressures acting on the two sexes over evolutionary time. Women have stood to gain less than men from risk-taking, which among men is often related to reproductive competition. Moreover, women have more to lose in terms of reproductive fitness than men, because in primitive societies the death of the mother is a greater blow to the odds of a child’s survival than the death of a father. Indeed, the death of the mother often amounts to a death sentence for her children. Thus, Campbell argues, women’s minds have evolved to rate the costs of physical danger higher than men’s do.

PHYSICAL AGGRESSION AND DOMINANCE: As with risk-taking, sex differences in aggression and dominance appear early in development, being present from about two years of age. Among adults, the clearest evidence for sex differences comes from criminal activity, with men being incarcerated for violent offenses at a rate more than ten times that of women.

Men not only engage in more physical forms of attack, they also have more positive attitudes about aggression. They are more inclined to view it as an acceptable way of achieving one’s ends, and they experience less guilt and anxiety about having acted aggressively than women do.

NURTURANCE AND EMPATHY: Women score higher on most measures of empathy, which, to paraphrase a former president of the United States, consists of the ability to feel someone else’s pain. This greater empathy may be responsible for the heightened guilt and anxiety that women feel about acting aggressively.

The sexes also differ in the circumstances that attenuate empathy, as demonstrated by a recent study examining empathic responses with functional magnetic resonance imaging (fMRI) of the brain. Subjects watched two players playing a game, some players playing fairly and some unfairly. Players were then given electrical shocks.

When a player who had played fairly was shocked, both male and female subjects showed activation of brain areas that respond both to one’s own pain and to observation of pain in others. When an unfair player was shocked, however, the empathic response of male – but not female — subjects was substantially reduced. Areas of the brain associated with reward processing, on the other hand, showed enhanced activation in men, but not women, when the unfair player was shocked. These findings suggest that men’s empathy may be more easily “switched off” and that they may derive greater psychic satisfaction from inflicting harm on those perceived as deserving it.

PAIN TOLERANCE: Although it is commonly asserted that women have a higher tolerance for pain than men — a belief apparently resting on women’s endurance of painful childbirth — a large body of data refutes that argument. Instead, women generally withstand pain less well than men. A major review of pain studies found differences of over one-half a standard deviation for both pain threshold (the level at which a stimulus is perceived as painful) and pain tolerance (the level at which pain is no longer bearable).

Ethanol Production Consumes Six Units Of Energy To Produce Just One

Thursday, December 6th, 2007

Ethanol Production Consumes Six Units Of Energy To Produce Just One:

Patzek’s ethanol critique began during a freshman seminar he taught in which he and his students calculated the energy balance of the biofuel. Taking into account the energy required to grow the corn and convert it into ethanol, they determined that burning the biofuel as a gasoline additive actually results in a net energy loss of 65 percent. Later, Patzek says he realized the loss is much more than that even.

“Limiting yourself to the energy balance, and within that balance, just the fossil fuel used, is just scraping the surface of the problem,” he says. “Corn is not ‘free energy.’”

Recently, Patzek published a fifty-page study on the subject in the journal Critical Reviews in Plant Science. This time, he factored in the myriad energy inputs required by industrial agriculture, from the amount of fuel used to produce fertilizers and corn seeds to the transportation and wastewater disposal costs. All told, he believes that the cumulative energy consumed in corn farming and ethanol production is six times greater than what the end product provides your car engine in terms of power.

Bruce Schneier Blazes Through Your Questions

Thursday, December 6th, 2007

The author of Beyond Fear, Bruce Schneier, blazes through questions on security from Freakonomics readers. I enjoyed this response:

Q: How do you remember all of your passwords?

A: I can’t. No one can; there are simply too many. But I have a few strategies. One, I choose the same password for all low-security applications. There are several Web sites where I pay for access, and I have the same password for all of them. Two, I write my passwords down. There’s this rampant myth that you shouldn’t write your passwords down. My advice is exactly the opposite. We already know how to secure small bits of paper. Write your passwords down on a small bit of paper, and put it with all of your other valuable small bits of paper: in your wallet. And three, I store my passwords in a program I designed called Password Safe. It’s is a small application — Windows only, sorry — that encrypts and secures all your passwords.

Here are two other resources: one concerning how to choose secure passwords (and how quickly passwords can be broken), and one on how lousy most passwords actually are.

The Legend of Brunhild

Thursday, December 6th, 2007

Ben Boxer has created a comic-strip version of The Legend of Brunhild.

As Adam at Drawn! noted: Happy ending not included.

Blond Hair Map

Thursday, December 6th, 2007

The Eupedia includes a page of maps of Europe by language, religion, population density, hair & eye color, etc..

Knut’s First Birthday

Wednesday, December 5th, 2007

It was Knut’s first birthday today — and he’s not the cute, little cub he used to be:

The Berlin Zoo’s famous polar bear Knut, who was rejected by his mother but went on to win the hearts of millions around the world, celebrated his first birthday Wednesday with more than 2,000 well-wishers.

But Knut — no longer a tiny cub, thanks partly to his penchant for croissants — probably didn’t get a taste of his own giant birthday cake, made with 300 eggs and 22 pounds of marzipan. He now tips the scales at more than 240 pounds and has been on a diet since July.

His special treat, instead, was a healthier concoction of fresh fruit, vegetables and rice — topped with a toy wooden candle.

I hope he doesn’t end up like other child stars.

Serious Taboos

Wednesday, December 5th, 2007

As I’ve already mentioned, in Serious Play, Michael Schrage, of the MIT Media Lab, examines how organizations use models, simulations, and prototypes to stimulate innovation.

He notes that when we want to learn about an organization, we should fight the impulse to look at what it puts into its models and simulations:

“I’ve learned that you learn far more about an organization from what they won’t model than from what they do,” asserts political scientist Garry Brewer, coauthor of the classic study of U.S. military simulations The War Game. “What I’ve observed — in both the military and private industry — is that organizations frequently leave out the very assumptions that are most important or most threatening to their sense of themselves. They always have a ‘good reason’ for this…. As a result, many organizations expend an extraordinary amount of effort developing models that can never be as useful or as valid as they say they want.”

For example:

In its war games during the 1980s, for example, the U.S. Navy would not allow aircraft carriers — its biggest, most expensive, and perhaps most controversial weapons platform — to be sunk hypothetically. This taboo persisted even after the Argentines successfully sank a British carrier during the Falklands War. It held fast even when the navy’s own submariners argued that carriers were particularly vulnerable to under-sea attack. For a variety of budgetary, political, interservice-rivalry and national-security reasons, the navy was permitted to run extensive war games and simulations in which its biggest and most vulnerable carriers were given a pass. The taboo was tacitly respected in virtually all formal reviews. External efforts to simulate conflicts in which carriers were destroyed were met with threats of security classification. One result, documented in Thomas B. Allen’s War Games, a popular history of U.S. war gaming, is that the navy acquired a reputation for cheating that undermined the credibility of naval proposals and exacerbated interservice rivalries. This particular taboo was deeply ironic because, as Harvard’s Stephen Peter Rosen ably documents in Winning the Next War, simulations and war games had been largely responsible for encouraging the navy to adopt aircraft carriers in the first place.

I discussed the U.S. Navy’s effective use of war games in Learning to Learn to Fight.

Erratum: I bow to mon frère‘s superior war-nerditry, for he caught this error in Schrage’s text: The HMS Sheffield was a destroyer not a carrier.

Soda, sweet drinks main source of calories in U.S.

Wednesday, December 5th, 2007

Soda, sweet drinks main source of calories in U.S.:

Tufts researchers recently reported that while the leading source of calories in the average American diet used to be from white bread, that may have changed. Now, according to preliminary research conducted by scientists at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Americans are drinking these calories instead.
[...]
Among respondents to the 1999-2000 National Health and Nutrition Examination Survey (NHANES), more than two thirds reported drinking enough soda and/or sweet drinks to provide them with a greater proportion of daily calories than any other food. In addition, obesity rates were higher among these sweet drink consumers. Consumers of 100% orange juice and low fat milk, on the other hand, tended to be less overweight, on average.

Knut’s First Birthday

Wednesday, December 5th, 2007

It was Knut’s first birthday today — and he’s not the cute, little cub he used to be:

The Berlin Zoo’s famous polar bear Knut, who was rejected by his mother but went on to win the hearts of millions around the world, celebrated his first birthday Wednesday with more than 2,000 well-wishers.

But Knut — no longer a tiny cub, thanks partly to his penchant for croissants — probably didn’t get a taste of his own giant birthday cake, made with 300 eggs and 22 pounds of marzipan. He now tips the scales at more than 240 pounds and has been on a diet since July.

His special treat, instead, was a healthier concoction of fresh fruit, vegetables and rice — topped with a toy wooden candle.

I hope he doesn’t end up like other child stars.

Antibiotics may not aid sinus infections

Wednesday, December 5th, 2007

Antibiotics may not aid sinus infections — or, more specifically, amoxicillin may not aid in most sinus infections:

Researchers randomly assigned 240 adults to receive one of four treatments: 500 milligrams of amoxicillin three times daily for seven days and 400 units of steroid spray for 10 days; only amoxicillin; only steroid spray; or fake medicine.

Patients on the drugs didn’t get better quicker than those using the placebo.

Sinus infections are diagnosed in about 31 million Americans each year and are among the most common reasons for doctor visits. In the United Kingdom, primary care doctors see 50 or more cases a year, the study authors said.

The infections affect air spaces called sinuses around the nose and in the lower forehead. Inflammation and excess mucous can cause nose congestion, headaches and eye and face pain. Causes include bacteria, viruses, fungal infections and allergies.

Despite a long-held notion, recent studies have found that yellowish or greenish mucous doesn’t always mean the infections are bacterial, said Dr. Vincenza Snow, a Philadelphia internist and director of clinical programs and quality of care at the American College of Physicians.

Moreover, while antibiotics are designed to treat bacteria, these drugs aren’t always very effective at treating bacterial sinus infections because the medicine has a tough time reaching the sinuses, she said.

The U.S. physicians’ group issued guidelines in 2001 advising against using antibiotics for most sinus infections in otherwise healthy people, blaming overuse for contributing to the growing problem of bacteria resistant to drugs.

Fitness trumps fatness in longevity study

Wednesday, December 5th, 2007

Fitness trumps fatness in longevity study:

Men and women who were fit, as judged by a treadmill test, but were overweight or obese had a lower mortality risk than those of normal weight but low fitness levels, the study in the Journal of the American Medical Association showed.

Exercise expert Steven Blair of the University of South Carolina and colleagues tracked about 2,600 people age 60 and up, examining how physical fitness and body fat affected their death rates over 12 years.

Those in the lowest fifth in terms of fitness had a death rate four times higher than participants ranked in the top fifth for fitness.
[...]
The researchers assessed the fitness of the participants using a treadmill test, seeing how long they could walk while the treadmill’s incline increased. They measured body mass index — calculated from a person’s weight and height — as well as waist circumference and body fat percentage.

The study showed that even a modest effort to improve physical activity can provide health benefits, the researchers said. Those in the bottom fifth in terms of fitness were about twice as likely to die than those in the next fifth.

Protein found to turn up metabolism in mice

Wednesday, December 5th, 2007

Protein found to turn up metabolism in mice — and increase their average lifespan:

Tricking muscle tissue to burn rather than store fat has succeeded in increasing the average life span of mice and staved off some age-related diseases, U.S. researchers said on Tuesday.

Mice bred to make too much of a protein known as uncoupling protein 1 released food energy as heat instead of storing it as fat.

“What we’re uncoupling is the process of burning energy from storing energy,” said Dr. Clay Semenkovich of Washington University School of Medicine in St. Louis, Missouri whose research appears in the journal Cell Metabolism.

“Normally when you metabolize food, you take the energy that comes from that food and you store it. In essence, you are coupling the energy in the food into a stored form,” Semenkovich said in a telephone interview.

Mice that overproduced this uncoupling protein in their muscle tissue weighed less and had less fat tissue, even though they ate the same amount as normal mice in the study.

“They lived about three months longer on average, which translates into six or seven years in human life, which is pretty good,” Semenkovich said.

The protein did not extend the maximum life span of the mice, but it did increase their average life span, perhaps because they were less prone to age-related diseases, Semenkovich said.

Mice in the study had a lower incidence of vascular disease, hypertension and lymphoma, a type of cancer.

Semenkovich said these same uncoupling proteins occur in humans, and genetic variations in the proteins have been linked with people weighing more or less.

“It may be possible to accelerate metabolism and find an alternative way of treating diseases,” he said.

Soda, sweet drinks main source of calories in U.S.

Wednesday, December 5th, 2007

Soda, sweet drinks main source of calories in U.S.:

Tufts researchers recently reported that while the leading source of calories in the average American diet used to be from white bread, that may have changed. Now, according to preliminary research conducted by scientists at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Americans are drinking these calories instead.
[...]
Among respondents to the 1999-2000 National Health and Nutrition Examination Survey (NHANES), more than two thirds reported drinking enough soda and/or sweet drinks to provide them with a greater proportion of daily calories than any other food. In addition, obesity rates were higher among these sweet drink consumers. Consumers of 100% orange juice and low fat milk, on the other hand, tended to be less overweight, on average.