Fatostatin

Friday, August 28th, 2009

Researchers have developed a drug that makes mice lose weight, reverses their diabetes, and lowers their cholesterol — and they’ve dubbed it fatostatin. Seriously:

Fatostatin is a small molecule, meaning it has the potential to be absorbed in pill form.

It works on so-called sterol regulatory element binding proteins or SREBPs, which are transcription factors that activate genes involved in making cholesterol and fatty acids.

“Fatostatin blocked increases in body weight, blood glucose, and hepatic (liver) fat accumulation in (genetically) obese mice, even under uncontrolled food intake,” the researchers wrote.

Genetic tests showed the drug affected 63 different genes.

The idea of interfering with SREBP is not new. GlaxSmithKline has been working on a new-generation cholesterol drug that uses this pathway.

After four weeks, mice injected with fatostatin weighed 12 percent less and had 70 percent lower blood sugar levels, the researchers wrote.

Now they plan to test rats and rabbits, Wakil said.

Not Quite Hercules

Friday, August 21st, 2009

When I recently read an old Modern Mechanix piece from 1930, I came across this old Charles Atlas ad, featuring his measurements:

I couldn’t help but wonder, where are his thigh measurements? Heck, where are his thighs? Everything else seems close to the classic Greek ideals, but his legs seem scrawny — not quite Hercules:

Born to Run

Tuesday, August 11th, 2009

James McCormick is a miserable runner, he says, but he enjoyed Christopher McDougall’s Born to Run: A Hidden Tribe, Superathletes, and the Greatest Race the World Has Never Seen:

In Born to Run, magazine writer McDougall has managed to bring together a tale of endurance running, sports capitalism, evolutionary biology, and Mexican ethnography to create a compelling reading experience. Maybe, just maybe, it’s an insight into who we were.

A chance reading of a Spanish language magazine article on the exceptional running achievements of the Tarahumara Indians led the author on a multi-year quest to confirm what seemed counter-intuitive. A tribe of people (men and women) who could run incredible distances well into old age, without exotic diets, footwear, training regimes, warm-ups, etc. etc. Like the !Kung, they were reputed to run down deer through sheer stamina. As an oft-injured runner himself, McDougall simply couldn’t believe it. The Copper Canyon area of Mexico, where the Tarahumara live, is a remote, rugged, but increasingly dangerous part of Mexico where drug gangs, dope growers, and resource extraction compete to make life miserable for the natives. The author took considerable risks on his first journey to visit these people, only to discover that a white man had been living, and running, among them for many years — The White Horse — Caballo Blanco.

The story thread running through Born to Run is Caballo Blanco’s efforts to assemble a small group of America’s elite ultradistance runners to compete in a race through the mountains of Mexico with the best runners of the Tarahumara. Included in the mix are one of the leading American advocates of barefoot running, and the author himself, attempting to recover from years of running injuries by altering his training to mirror Tarahumara methods. In providing a back story for this race, McDougall notes that the Tarahumara once made a huge splash in the running world in the 1990s by twice dominating a brutal high-altitude race in Colorado, the Leadville 100. Then they “disappeared.” By weaving the biographical details of the Western participants in the 2006 race, with the ethnographic literature of the Tarahumara, the author sets the scene for the friendly showdown, a “middle of nowhere” mountain race out of sight of cameras and the world’s attention. At the same time, McDougall gets a chance to make his case for the negative effects of high-tech running shoes on runner health and performance … and for the evolutionary forces that apparently shaped the human frame for endurance running even before our species made tools or used fire.

It’s a possibility that our ancestors ran down their prey for tens of thousands of years without leaving a single trace in the archaeological record. Selective forces slowly altered their physiology (large head, springy Achilles tendon, hairless skin, upright posture) in ways that made it simply impossible for game animals to out-run humans. I must admit, I was shocked when the author outlined the limitations of four-legged creatures when it comes to running. For sprints, no problem. For long distances, however, the humans win. When added to the advanced cognition required for tracking and predicting game movement (proposed by South African scholar, Louis Liebenberg), one school of scholars now firmly proposes the “Running Man” theory of human evolution — that we are literally born to run down animals. That is our niche in the world.

So this book is a skillful mix of adventure tale, archival research, plus interviews with running coaches, physiologists, race directors, and evolutionary biologists … culminating in that “secret” race in Mexico in 2006.

Charles Atlas

Wednesday, August 5th, 2009

This year marks the 80th that Charles Atlas‘s mail-order company has been in business:

Atlas himself is long gone — he died in 1972 — and Charles Atlas Ltd. now operates out of a combined shrine, archive and office over a nail salon in the northern New Jersey town of Harrington Park. But the Internet has given Dynamic-Tension a new life. From all over the world, letters and e-mails continue to pour in, testament to one of the most successful fitness programs ever devised. And to its mythic founder.

The man who made history marketing his muscles was an unlikely hero. Born in Acri, a tiny town in southern Italy, he arrived with his parents at Ellis Island in 1903 at age 10. His name was Angelo Siciliano, and he spoke not a word of English.

He didn’t look like much, either. Skinny and slope-shouldered, feeble and often ill, he was picked on by bullies in the Brooklyn neighborhood where his family had settled, and his own uncle beat him for getting into fights. He found little refuge at Coney Island Beach, where a hunky lifeguard kicked sand in his face and a girlfriend sighed when the 97-pound Atlas swore revenge.

On a visit to the Brooklyn Museum, he saw statuary depicting Hercules, Apollo and Zeus. That, and Coney Island’s side show, got him thinking. Body building was then a fringe pursuit, its practitioners consigned to the freak tents beside the fat lady and the sword swallower. Alone at the top was Eugen Sandow, a Prussian strongman discovered by showman Florenz Ziegfeld. Sandow toured vaude ville theaters, lifting ponies and popping chains with his chest. Atlas pasted a photo of Sandow on his dresser mirror and, hoping to transform his own body, spent months sweating away at home with a series of makeshift weights, ropes and elastic grips. The results were disappointing, but on a visit to the Bronx Zoo one day he had an epiphany, or so he would recall in his biography Yours in Perfect Manhood, by Charles Gaines and George Butler. Watching a lion stretch, he thought to himself, “Does this old gentleman have any barbells, any exercisers?…And it came over me….He’s been pitting one muscle against another!”

Some of us might draw another conclusion: he’s a lion. Anyway, this supposedly drove Atlas to create his method of dynamic tension:

Atlas threw out his equipment. He began flexing his muscles, using isometric opposition and adding range of motion to stress them further. He tensed his hands behind his back. He laced his fingers under his thighs and pushed his hands against his legs. He did biceps curls with one arm and squeezed his fist down with the other. Experimenting with varied techniques, and likely aided by exceptional genes, Atlas emerged from many months at home with a physique that stunned school chums when he first revealed himself on the beach. One of the boys exclaimed, “You look like that statue of Atlas on top of the Atlas Hotel!”

Fans of the old pulp hero, Doc Savage, may recognize dynamic tension in his series of special exercises pitting one muscle against another to build tremendous strength and endurance.

Anyway, Charles Atlas got his big break when an artist spotted him on the beach in 1916:

A boom in public sculpture was coming, and busy carvers were desperate for models with well-built bodies. Among the most prominent was socialite sculptor Gertrude Vanderbilt Whitney, who, watching Atlas disrobe, exclaimed, “He’s a knockout!” Further impressed by his ability to hold a pose for 30 minutes, she soon had him running from studio to studio. By the time he was 25, Atlas was everywhere, posing as George Washington in Washington Square Park, as Civic Virtue in Queens Borough Hall, as Alexander Hamilton in the nation’s capital. He was Dawn of Glory in Brooklyn’s Prospect Park and Patriotism for the Elks’ national headquarters in Chicago.

He went on to win a “World’s Most Beautiful Man” photo contest sponsored by Physical Culture magazine. When he brought on a savvy marketer, Charles Roman, who coined the dynamic-tension name, the money started rolling in. It didn’t last forever — but it has come back:

It turned out the World Wide Web was the perfect marketing tool: cheaper even than the back pages of comics, international in scope, the ideal vehicle for mail-order sales. Seemingly immune from inflation — the course now sells for $49.95, only $20 more than in the early 1930s — Atlas’ promise to “Make You a New Man!” was only a click away in banner ads on youth-oriented sites. The company says it now does 80 percent of its business online. “We are literally overwhelmed by the Web site activity,” says Hogue, who declines to provide figures on revenue or growth. And such high-profile brands as the Gap, Mercedes and IBM have licensed the Atlas image or “Hey, Skinny!” comic strips for retro advertisements.

Frankly, I’m shocked that his mail-order course could sell for anywhere near $29.95 in the 1930s. That’s the equivalent of hundreds of dollars today. The ads themselves offer a free 32-page illustrated book. I guess you don’t have to convert too many of those to make a decent living. It’s sure easier than selling and shipping iron weights.

Organic has no health benefits

Thursday, July 30th, 2009

Organic has no health benefits, according to researchers from the London School of Hygiene and Tropical Medicine:

Among the 55 of 162 studies that were included in the final analysis, there were a small number of differences in nutrition between organic and conventionally produced food but not large enough to be of any public health relevance, said study leader Dr Alan Dangour.
Overall the report, which is published in the American Journal of Clinical Nutrition, found no differences in most nutrients in organically or conventionally grown crops, including in vitamin C, calcium, and iron.

The same was true for studies looking at meat, dairy and eggs.

Differences that were detected, for example in levels of nitrogen and phosphorus, were most likely to be due to differences in fertilizer use and ripeness at harvest and are unlikely to provide any health benefit, the report concluded.

The study ignored what I would consider the primary reason for going organic: avoiding pesticides.

A mystery batter-dipped in an enigma

Tuesday, July 14th, 2009

Elizabeth Kolbert calls it a mystery batter-dipped in an enigma:

According to the first National Health study, which was done in the early nineteen-sixties, 24.3 per cent of American adults were overweight — roughly defined as having a body-mass index greater than twenty-seven. (The metrics are slightly different for men and women; by the study’s definition, a woman who is five feet tall would count as overweight if she was more than a hundred and forty pounds, and a man who is six feet tall if he weighed more than two hundred and four pounds.)

By the time of the second survey, conducted in the early nineteen-seventies, the proportion of overweight adults had increased by three-quarters of a per cent, to twenty-five per cent, and, by the third survey, in the late seventies, it had edged up to 25.4 per cent. The results that Flegal found so surprising came from the fourth survey. During the nineteen-eighties, the American gut, instead of expanding very gradually, had ballooned: 33.3 per cent of adults now qualified as overweight.

Flegal began asking around at professional meetings. Had other researchers noticed a change in Americans’ waistlines? They had not. This left her feeling even more perplexed. She knew that errors could have sneaked into the data in a variety of ways, so she and her colleagues checked and rechecked the figures. There was no problem that they could identify. Finally, in 1994, they published their findings in the Journal of the American Medical Association. In just ten years, they showed, Americans had collectively gained more than a billion pounds. “If this was about tuberculosis, it would be called an epidemic,” another researcher wrote in an editorial accompanying the report.

During the next decade, Americans kept right on gaining. Men are now on average seventeen pounds heavier than they were in the late seventies, and for women that figure is even higher: nineteen pounds. The proportion of overweight children, age six to eleven, has more than doubled, while the proportion of overweight adolescents, age twelve to nineteen, has more than tripled.

(According to the standards of the United States military, forty per cent of young women and twenty-five per cent of young men weigh too much to enlist.)

One explanation is known as the mismatch paradigm:

“We evolved on the savannahs of Africa,” Power and Schulkin write. “We now live in Candyland.”

But that doesn’t explain the recent increase in weight — which might be an economic phenomenon:

Between 1983 and 2005, the real cost of fats and oils declined by sixteen per cent. During the same period, the real cost of soft drinks dropped by more than twenty per cent.

“For most people, an ice cold Coca-Cola used to be a treat reserved for special occasions,” Finkelstein observes. Today, soft drinks account for about seven per cent of all the calories ingested in the United States, making them “the number one food consumed in the American diet.” If, instead of sweetened beverages, the average American drank water, Finkelstein calculates, he or she would weigh fifteen pounds less.

Much of the issue revolves around portion sizes:

n the early nineteen-sixties, a mannamed David Wallerstein was running a chain of movie theatres in the Midwest and wondering how to boost popcorn sales. Wallerstein had already tried matinée pricing and two-for-one specials, but to no avail. According to Greg Critser, the author of “Fat Land (2003), one night the answer came to him: jumbo-sized boxes. Once Wallerstein introduced the bigger boxes, popcorn sales at his theatres soared, and so did those of another high-margin item, soda.

A decade later, Wallerstein had retired from the movie business and was serving on McDonald’s board of directors when the chain confronted a similar problem. Customers were purchasing a burger and perhaps a soft drink or a bag of fries, and then leaving. How could they be persuaded to buy more? Wallerstein’s suggestion — a bigger bag of fries — was greeted skeptically by the company’s founder, Ray Kroc. Kroc pointed out that if people wanted more fries they could always order a second bag.

“But Ray,” Wallerstein is reputed to have said, “they don’t want to eat two bags — they don’t want to look like a glutton.” Eventually, Kroc let himself be convinced; the rest, as they say, is supersizing.

The elasticity of the human appetite is the subject of Brian Wansink’s Mindless Eating (2006). Wansink is the director of Cornell University’s Food and Brand Lab, and he has performed all sorts of experiments to test how much people will eat under varying circumstances. These have convinced him that people are — to put it politely — rather dim. They have no idea how much they want to eat or, once they have eaten, how much they’ve consumed. Instead, they rely on external cues, like portion size, to tell them when to stop. The result is that as French-fry bags get bigger, so, too, do French-fry eaters.

Consider the movie-matinée experiment. Some years ago, Wansink and his graduate students handed out buckets of popcorn to Saturday-afternoon filmgoers in Chicago. The popcorn had been prepared almost a week earlier, and then allowed to become hopelessly, squeakily stale. Some patrons got medium-sized buckets of stale popcorn and some got large ones. (A few, forgetting that the snack had been free, demanded their money back.) After the film, Wansink weighed the remaining kernels. He found that people who’d been given bigger buckets had eaten, on average, fifty-three per cent more.

In another experiment, Wansink invited participants to cook dinner for themselves with ingredients that he provided. One group got big boxes of pasta and big bottles of sauce, a second smaller boxes and smaller bottles. The first group prepared twenty-three per cent more, and downed it all. In yet another experiment, Wansink rigged up bowls that could be refilled, via a hidden tube. When he served soup out of the trick bowls, people, he writes, “ate and ate and ate.” On average, they consumed seventy-three per cent more than those who were served from regular bowls. “Give them a lot and they eat a lot,” he writes.

Before McDonald’s discovered the power of re-portioning, it offered just a small bag of French fries, which contained two hundred calories. Today, a small order of fries has two hundred and thirty calories, and a large order five hundred. (Add fifteen calories for each package of ketchup.) Similarly, a McDonald’s soda used to be eight ounces. Today, a small soda is sixteen ounces (a hundred and fifty calories), and a large soda is thirty-two ounces (three hundred calories).

Perhaps owing to the influence of fast-food culture, up-sizing has by now spread to all sorts of other venues. In a 2002 study, Marion Nestle, a nutrition professor at New York University, and Lisa Young, an adjunct there, examined the offerings, past and present, at American supermarkets. They found that during the nineteen-eighties the amount of food that was counted as a single serving increased rapidly.

A similar jump showed up in cookbooks; when the researchers compared dessert recipes in old and new editions of volumes like The Joy of Cooking, they discovered that, even in cases where the recipes themselves had remained unchanged, the predicted number of servings had shrunk.

According to the federally supported National Heart, Lung, and Blood Institute, the bagels that Americans eat have in the past twenty years swelled from a hundred and forty to three hundred and fifty calories each. If, as Wansink argues, people are relying on external cues to determine their consumption, then the new, bigger bagel is sneaking in an additional two hundred and ten calories. For someone who is in the habit of eating a bagel a day, these extra calories translate into a weight gain of more than a pound a month.

High-Tech Weights for Space Workout

Saturday, April 18th, 2009

The rocket scientists at NASA have devised some high-tech “weights” for space workouts:

In the first-ever analysis of muscles from International Space Station astronauts, Trappe’s team found that six months in near zero-gravity had produced a 15 percent loss in muscle volume and 25 percent loss in strength.
[...]
However, the exercise of space station astronauts is limited to the machines they’re given. Though a treadmill and stationary bicycle work fine, they’re intended primarily for aerobic conditioning. Muscle strength is the responsibility of the Interim Resistance Exercise Device, or iRED — and, with a maximum resistance of just 300 pounds, it can’t do the job.

“Astronauts are working out hard, but the loading characteristics aren’t there,” said Trappe. “They’re losing more muscle mass than they should be.”

Simply maintaining muscle mass in space, said Trappe, requires a high-weight, low-repetition workout. The aRED is the first piece of NASA exercise equipment to meet this need. Providing resistance in each exercise are two piston-driven vacuum cylinders that are a bit like oversize bicycle pumps. Resistance increases as a piston is pulled in or out, so weights are set by adjusting the length of a mechanical arm that attaches pistons to lift bar.

Attached to the pistons is a flywheel, explained NASA astronaut strength conditioning and rehabilitation specialist Jim Loehr. Pushing the pistons out sets the flywheels spinning. That rotation, combined with vacuum pressure, provides a counter force against direction reversal so that a leg press in space requires effort as the weight is returned to its starting position, just as it does on Earth.

“ARED was designed to provide a constant force throughout the range of motion,” said Loehr, mimicking the physiological gold standard of free weight resistance. In contrast, the iRED was a 21st century version of a Bowflex machine, with unidirectional resistance provided by an ingenious arrangement of rubber bands that provide an “ascending force curve that doesn’t match traditional free weights,” and can lose strength over time.

For some exercises, like squats, a person needs to lift twice as much weight in space to get the same result as on Earth. So iRED’s maximum weight of 300 pounds translates to just 150 pounds squatted on Earth. Maintaining leg strength becomes extremely difficult with that amount of weight. And it’s the legs, accustomed to constantly supporting our bulks against Earth gravity, that weaken first in space. ARED’s maximum load of 600 pounds means astronauts can squat the equivalent of 300 pounds on Earth, which should be enough to keep their legs in shape.

Another problem with a Bowflex-style apparatus, said Trappe, is safety. “They have all these rubber cords and things attached to it that could snap,” he said, explaining that people fail to appreciate the extraordinary demands placed upon exercise machines in space.

Relying on pistons and fly wheels sounds less like a requirement and more like an interesting problem for the techies to solve.

I find it particularly amusing that the iRED is considered flawed because its ascending force curve doesn’t match free weights’ flat force curve, when earth-bound powerlifters now rely on elastic bands and metal chains attached to their barbells in order to attain just such an ascending force curve. The human body can handle more weight at the top of a squat or bench press than at the bottom. (And the specialized lifting suits allowed in powerlifting help more at the bottom than at the top.)

Anyway, with “just” 300 pounds of resistance and no body weight, a decent trainer would recommend some variation on split squats or true one-legged squats. But I don’t suppose they have a whole lot of trainers there at NASA.

Calorie-Burning Brown Fat

Thursday, April 9th, 2009

Rodents, unable to shiver, use calorie-burning brown fat to stay warm. So do human infants. So do human adults, it turns out; scientists just didn’t know how to look for it:

The key to finding brown fat in humans was PET-CT scans. The PET scans pinpoint areas where cells are actively burning glucose and the CT scans identify it as fat. Because brown fat rapidly burns glucose to produce heat, it lights up in PET scans. In two of the three studies, investigators also studied samples of brown fat that were removed from a few subjects, confirming that the cells had a protein, UCP-1, that is unique to brown fat.

Brown fat in adult humans was in an unexpected place. Infants have it mostly as a sheet of cells covering their backs. Rodents have it mostly between their shoulder blades, just down from the neck. But in adult humans, it showed up in the upper back, on the side of the neck, in the dip between the collarbone and shoulder, and along the spine.

That may be one reason it was missed for so long, Dr. Kahn said.

“There was an interest in looking at humans 20 or 25 years ago with different scanning techniques, but people were always looking between the shoulder blades,” he said. And since there is so little brown fat — just a few grams of tissue — it can be hard to find, Dr. Kahn added.

His study, one of the three published Thursday, involved 1,972 people who had had PET-CT scans for a variety of reasons. The scans showed brown fat in 7.5 percent of the women and 3 percent of the men — an underestimate, Dr. Kahn says, because the people had not activated brown fat by getting cold.

Dr. Kahn and his colleagues also examined surgical samples taken from the necks of two patients. They concluded that what looked like brown fat in their scans was indeed brown fat.

A second study, led by Wouter D. van Marken Lichtenbelt of Maastricht University in the Netherlands, involved 24 healthy young men. Ten were lean, the rest overweight or obese.

The scans showed no brown fat when the men had been in a room that was a comfortable temperature. But after they were in a chilly room for two hours, scans showed brown fat in all but one, an obese man.

A third study, led by Dr. Sven Enerbäck of the University of Goteborg in Sweden, involved five healthy adults. Each had two scans — one after being in a room at a comfortable temperature, the other after being in a chilly room for two hours. The investigators saw brown fat in their chilled subjects. Three participants allowed the researchers to remove some white fat and some brown fat to demonstrate that what looked like brown fat in the scans really was that elusive substance.

The studies, investigators say, should stimulate research on safe ways to activate brown fat. It is known to be activated not only by cold but also by catecholamines, hormones that are part of the fight or flight response. That is why beta blockers, which block catecholamines, can suppress brown fat activation.

Epinephrine, or adrenaline, and ephedra, an herbal supplement containing epinephrine, can stimulate brown fat, said Dr. Rudolph Leibel, co-director of the Naomi Berrie Diabetes Center at the Columbia University Medical Center. But the drugs have too many side effects to be used for weight loss, he said, adding that while caffeine can bolster ephedra’s effects, it is easy to eat your way out of a brown fat effect.

Study finds 1 in 5 obese among 4-year-olds

Thursday, April 9th, 2009

Study finds 1 in 5 obese among 4-year-olds:

A striking new study says almost 1 in 5 American 4-year-olds is obese, and the rate is alarmingly higher among American Indian children, with nearly a third of them obese. Researchers were surprised to see differences by race at so early an age.

Overall, more than half a million 4-year-olds are obese, the study suggests. Obesity is more common in Hispanic and black youngsters, too, but the disparity is most startling in American Indians, whose rate is almost double that of whites.
[...]
The study is an analysis of nationally representative height and weight data on 8,550 preschoolers born in 2001. Children were measured in their homes and were part of a study conducted by the government’s National Center for Education Statistics. The results appear in Monday’s Archives of Pediatrics & Adolescent Medicine.

Almost 13 percent of Asian children were obese, along with 16 percent of whites, almost 21 percent of blacks, 22 percent of Hispanics, and 31 percent of American Indians.

Children were considered obese if their body-mass index, a height-weight ratio, was in the 95th percentile or higher based on government BMI growth charts. For 4-year-olds, that would be a BMI of about 18.

In case it didn’t jump out at you, 18 percent of children are in the top 5 percent. Hmm…

Morbidly obese adults almost completely sedentary

Wednesday, April 8th, 2009

It should come as no surprise that morbidly obese adults are almost completely sedentary:

Morbidly obese adults [BMI 40+] are sedentary for more than 99 percent of the day, getting only a fraction of the amount of walking that experts recommend for staying healthy, a small study suggests.

The study of 10 men and women found that participants spent an average of 23 hours and 52 minutes sleeping, lying down or sitting each day. They typically took about 3,700 steps throughout the day — compared with the 10,000 steps that experts recommend for healthy living.

The average person does not log 10,000 steps per day either. Men average over 7,000, women over 5,000.

Teeth are able to heal themselves

Saturday, April 4th, 2009

Your dentist probably never told you that teeth are able to heal themselves:

That’s how traditional cultures such as the Inuit can wear their teeth down to the pulp due to chewing leather and sand-covered dried fish, yet still have an exceptionally low rate of tooth decay. It’s also how the African Wakamba tribe can file their front teeth into sharp points without causing decay. Both cultures lost their resistance to tooth decay after adopting nutrient-poor Western foods such as white flour and sugar.

So, it looks like there’s a good reason your dentist never told you that teeth can heal — in his experience, they don’t. Americans — especially those who get cavities that need healing — eat a modern diet full of white flour and sugar:

When enamel is poorly formed and the diet isn’t adequate, enamel dissolves and decay sets in. Tooth decay is an opportunistic infection that takes advantage of poorly built or maintained teeth. If the diet remains inadequate, the tooth has to be filled or removed, or the person risks more serious complications.

Edward Mellanby had this to say — about his wife’s research on dog teeth — in his Nutrition and Disease:

Since the days of John Hunter it has been known that when the enamel and dentine are injured by attrition or caries, teeth do not remain passive but respond to the injury by producing a reaction of the odontoblasts in the dental pulp in an area generally corresponding to the damaged tissue and resulting in a laying down of what is known as secondary dentine.

In 1922 M. Mellanby proceeded to investigate this phenomenon under varying nutritional conditions and found that she could control the secondary dentine laid down in the teeth of animals as a reaction to attrition both in quality and quantity, independently of the original structure of the tooth.

Thus, when a diet of high calcifying qualities, ie., one rich in vitamin D, calcium and phosphorus was given to the dogs during the period of attrition, the new secondary dentine laid down was abundant and well formed whether the original structure of the teeth was good or bad.

On the other hand, a diet rich in cereals and poor in vitamin D resulted in the production of secondary dentine either small in amount or poorly calcified, and this happened even if the primary dentine was well formed.

What about humans?

Drs. Mellanby set out to see if they could use their dietary principles to cure tooth decay that was already established. They divided 62 children with cavities into three different diet groups for 6 months. Group 1 ate their normal diet plus oatmeal (rich in phytic acid). Group 2 ate their normal diet plus vitamin D. Group 3 ate a grain-free diet and took vitamin D.

Those three groups seem odd — where’s the control? — but the results are interesting:

Vitamin D does seem important for dental health.

How to Lose 30 Pounds in 24 Hours

Wednesday, March 18th, 2009

Former wrestler — and shameless self-promoter — Tim Ferriss (The 4-Hour Workweek) explains how to lose 30 pounds in 24 hours — that is, how to cut weight for a weight-classed sport with weigh-ins well ahead of competition:

If weigh-ins are hypothetically held at 9am Saturday morning, restrict additional salt intake beginning at Thursday dinner. No red meat or starchy carbohydrates (bread, rice, potatoes) should be consumed on Thursday night or on Friday, as both of these food product categories cause the disproportionate storage of water (3 grams of water per 1 gram of glycogen; creatine and fibrous tissue water retention in red meat). Drink your normal volume of liquids in the form of purified or distilled water until Friday morning, at which point water consumption, limited still to purified or distilled water, should be reduced to 1/3 your normal volume. If you don’t want to do the math, just drink 1/3 cup every time you would drink a full cup.

On Friday night, following a early (5–6pm) and light dinner consisting primarily of vegetables, thermoregulatory work should begin and water consumption should be eliminated until weigh-ins. Non-prescription diuretics, discussed in the following section, would be consumed at breakfast, lunch, and dinner on Friday, in addition to upon waking on Saturday.

Here’s where it gets interesting:

The bathtub is the preferred tool for dehydration based on the outside humidity in total submersion, which is 100%. The higher the humidity, the less the evaporation, and the more your body must sweat to cool core body temperature. This is why athletes will sweat more in a steam room than in a dry sauna. Fill the bathtub with water that does not burn the hand but causes moderate pain if the hand is moved underwater. Your target weight by bedtime should be 2–3 lbs. more than your necessary competition weight, as you will evaporate that volume range of water during 6–9 hours of sleep.

Set an alarm clock next to the bath for 10 minutes, and preferably have someone who will also alert you at the 10-minute mark. Submerge your entire body and head in the bathtub, entering which should take at least 2 minutes. For ease of entry and to minimize movement, sit cross-legged at the front of the bath and lay down slowly, putting your head underwater so that only your face is exposed to the air and pointing towards the ceiling. If you feel faint at any point or when you reach 10 minutes, exit the tub and run cold water over your scalp but no other areas; ideally, place an ice pack on your head and neck instead of using water. Towel off, but do not shower, as you will reabsorb water through the skin.

He also recommends two potassium-sparing non-prescription diuretics: dandelion root (Taraxicum officianalis) and caffeine:

Dandelion root has the highest vitamin A of any known plant (14,000 iu per 100 g of raw material) and a high choline content. Dandelion root is one of few commonly available plants that increases sodium chloride excretion by the renal (kidney) tubule while simultaneously exhibiting potassium-sparing properties. When sodium excretion is increased, the kidneys increase water excretion to maintain electrolyte and osmotic balance. Dosages for dehydration, based on a 4:1 extract, are 250–500 mg 3x daily with meals.

Caffeine not only increases sodium chloride excretion but acts primarily by increasing renal blood flow and stimulating parietal cells to increase gastric secretions. The latter combines with dandelion’s effect of increased bile flow to not only increase water excretion but food elimination (gastric emptying). Dosages for dehydration are 200–400 mg caffeine (preferably caffeine anhydrous) 2–3x daily with meals. 200 mg is roughly equivalent to two cups of drip coffee, or one medium cup of french-pressed coffee.

Used in combination for a 200 lb. competitor, 250–500 mg of dandelion root would be taken with 200–400 mg of caffeine at all three Friday meals (remember that dinner is early, 5–6 pm), and upon waking 3 hours prior to weigh-in at 9 am. It is recommended that the athlete also supplement each meal with a non-prescription 99 mg potassium product.

There’s a whole nuther complicated routine for rehydrating after weigh-ins, but it basically involves drinking water with some sodium and carbs — and glycerol.

How strong is a chimpanzee, really?

Friday, February 27th, 2009

I’ve been asking, How strong is a chimpanzee, really?, and John Hawks of Slate has done the research to answer that question — rather than repeat the same factoids going around:

After last week’s chimpanzee attack in Connecticut, in which an animal named Travis tore off the face of a middle-aged woman, primate experts interviewed by the media repeated an old statistic: Chimpanzees are five to eight times stronger than people. The literature — or at least 19th-century literature — concurs: Edgar Allan Poe’s fictional orangutan was able to hurl bodies and pull off scalps. Edgar Rice Burroughs’ fictional anthropoid apes were likewise possessed of remarkable strength. Even Jules Verne’s gentle ape, Jupiter, had the muscle to drag a stuck wagon from the mire.

In 1923 biologist John Bauman decided that a scalp-pulling orangutan was grotesquely impossible, so he decided to test the strength of actual apes at the Bronx Zoo with a dynamometer. The apes didn’t generally cooperate, but one chimp managed to pull 1,260 pounds. Later, the largest chimpanzee then in captivity, named Boma, pulled 847 pounds one-handed. This was more than the “husky lads” on his South Dakota football team could pull — 200 pounds with one hand, 500 with two.

This is the number that entered the anthropology textbooks and the talking points of primatologists like Jane Goodall and Sue Savage-Rumbaugh.

But the “five times” figure was refuted 20 years after Bauman’s experiments:

In 1943, Glen Finch of the Yale primate laboratory rigged an apparatus to test the arm strength of eight captive chimpanzees. An adult male chimp, he found, pulled about the same weight as an adult man. Once he’d corrected the measurement for their smaller body sizes, chimpanzees did turn out to be stronger than humans — but not by a factor of five or anything close to it.

Repeated tests in the 1960s confirmed this basic picture. A chimpanzee had, pound for pound, as much as twice the strength of a human when it came to pulling weights. The apes beat us in leg strength, too, despite our reliance on our legs for locomotion. A 2006 study found that bonobos can jump one-third higher than top-level human athletes, and bonobo legs generate as much force as humans nearly two times heavier.

Still impressive.

Chimps have proportionally more arm muscle than humans, but their muscles tend to be stronger in general, because chimps have the “strong” form of the ACTN3 gene — like Jamaican sprinters — and thus have more “fast twitch” muscle fibers.

Comparative Anatomy of Chimpanzee and Human

Friday, February 20th, 2009

The recent chimpanzee attack has raised the issue of how strong chimpanzees really are — a question that lacks a solid answer, since chimps rarely compete in either Olympic-style weightlifting or powerlifting.

The Human Evolution Coloring Book provides a useful illustration of the Comparative Anatomy of Chimpanzees and Humans:

Notice that the chimp has roughly twice the relative arm mass of a human. That alone would imply that chimps are stronger but less than twice as strong as similarly sized humans — 22/3 as strong — but their arms aren’t simply bigger human arms. How close tendons attach to the joint, for instance, can dramatically affect the mechanical advantage of a muscle — whether it’s naturally in low gear or high gear, so to speak.

Our illustration has other limitations, too. First, it shows a gracile chimpanzee, the Bonobo or Pan paniscus, rather than its more robust cousin, the Common Chimpanzee or Pan troglodytes. Second, it shows a human female, which arguably exaggerates the difference in upper-body and lower-body mass between species. Adult human males have dramatically more upper-body mass than females.

Vitamin C hampers adaptation to endurance training

Friday, February 20th, 2009

Dennis Mangan points to a fascinating study that shows that vitamin C hampers adaptation to endurance training:

Briefly, the authors took a group of young men and had them train on stationary bicycles. One group took one gram of vitamin C daily, the other did not. A parallel study was done on rats using the same general idea – only with rats, one can exercise them to exhaustion. The result: vitamin C put a major dent in the training effect due to exercise.

The figure above shows gene expression of two of the most important internal antioxidant-enhancing enzymes, superoxide dismutase and glutathione peroxidase. The first bar shows levels without training, the second with training, and the third with training plus vitamin C, which shows that the vitamin practically abolished the training effect. The reason seems to be that reactive oxygen species (ROS) formed during exercise are important signals for the synthesis of more mitochondria, the cell’s energy factories. Vitamin C quenches the ROS and thus the signals.