The enemy will snuff out one life, dozens, hundreds or thousands without any qualms if this would further his aims

Tuesday, April 15th, 2025

Total Resistance by H. Von DachThe 1957 military manual Total Resistance is the only Swiss book to ever land on Germany’s banned books list:

“One thing is certain,” the guide states. “The enemy will show no mercy.”

“The enemy will snuff out one life, dozens, hundreds or thousands without any qualms if this would further his aims. The captured soldier will face deportation, forced labor or death. But so will the worker, the employee, the self-employed and the housewife.”

Von Dach’s proposed solution was to arm and prepare these everyday people for a guerrilla war waged from mountains and the radioactive ruins of Swiss cities.

For a lot of reasons, the Swiss military never officially adopted the manual. The 173-page guide begins with the assumption that the Swiss army no longer exists as a cohesive fighting force in the aftermath of an invasion.

Yet the book was arguably more influential outside the country. German left-wing terrorists studied it during the Red Army Faction’s heydays during the 1970s and 1980s.

The German Federal Department for Media Harmful to Young Persons banned the book — only putting it up for review in 2013.

[…]

Translations spread globally, according to the Zurich newspaper Neue Zürcher Zeitung. America’s Special Operations Forces read it. The book circulated in Lebanon during the country’s civil war. Vietnamese insurgents allegedly studied it during the 1960s.

But there’s not much evidence the Swiss military took the book very seriously.

[…]

There’s techniques on how to avoid patrolling helicopters and hiding incriminating documents. There’s tips for sabotaging railroads, power lines and parked aircraft. The guide has battle tactics for surrounding and overrunning isolated outposts.

There’s even illustrations on “disposing of guards without any notice” with an axe. “Obliquely between the small of the back and loin,” the book states.

Perhaps showing its age, the guide recommends keeping a reserve of horses and wagons near planned ambushes—for carrying captured supplies away.

Although unofficial, Von Dach’s book did influence Swiss military exercises well into the 1990s. Soldiers learned how to attacks tanks with grenades attached to gasoline cans—a technique similar to those found in Total Resistance.

They’re arguments that could be defused but aren’t

Monday, April 14th, 2025

Unforgiving Places by Jens LudwigTyler Cowen cites “the new and interesting” Unforgiving Places: The Unexpected Origins of American Gun Violence, by Jens Ludwig:

An estimated 80 percent [of U.S.gun shootings] seem to instead be crimes of passion — including rage.  They’re arguments that could be defused but aren’t, then end in tragedy because someone has a gun.  Most violent crimes are the result of human behavior gone temporarily haywire, not premeditated acts for financial benefit.

I can’t be sure if his surprise is feigned or sincere.

Joe Lonsdale presents a blueprint for FDA reform

Sunday, April 13th, 2025

The new FDA report from Joe Lonsdale and team is impressive, Alex Tabarrok says, as he shares a few of the recommendation which caught his eye:

In the U.S., anyone running a clinical trial must manufacture their product under full Good Manufacturing Practices (GMP) regardless of stage. This adds enormous cost (often $10M+) and more importantly, as much as a year’s delay to early-stage research. Beyond the cost and time, these requirements are outright irrational: for example, the FDA often requires three months of stability testing for a drug patients will receive after two weeks. Why do we care if it’s stable after we’ve already administered it? Or take AAV manufacturing—the FDA requires both a potency assay and an infectivity assay, even though potency necessarily reflects infectivity.

This change would not be unprecedented either. By contrast, countries like Australia and China permit Phase 1 trials with non-GMP drug with no evidence of increased patient harm.

[…]

With modern AI and digital infrastructure, trials should be designed for machine-readable outputs that flow directly to FDA systems, allowing regulators to review data as it accumulates without breaking blinding. No more waiting nine months for report writing or twelve months for post-trial review. The FDA should create standard data formats (akin to GAAP in finance) and waive documentation requirements for data it already ingests. In parallel, the agency should partner with a top AI company to train an LLM on historical submissions, triaging reviewer workload so human attention is focused only where the model flags concern. The goal is simple: get to “yes” or “no” within weeks, not years.

[…]

When negative results aren’t published, companies duplicate failed efforts, investors misallocate capital, and scientists miss opportunities to refine hypotheses. Publishing all trial outcomes — positive or negative—creates a shared base of knowledge that makes drug development faster, cheaper, and more rational. Silence benefits no one except underperforming sponsors; transparency accelerates innovation.

The FDA already has the authority to do so under section 801 of the FDAAA, but failed to adopt a more expansive rule in the past when it created clinicaltrials.gov. Every trial on clincaltrials.gov should have a publication associated with it that is accessible to the public, to benefit from the sacrifices inherent in a patient participating in a clinical trial.

[…]

We need multiple competing approval frameworks within HHS and/or FDA. Agencies like the VA, Medicare, Medicaid, or the Indian Health Service should be empowered to greenlight therapies for their unique populations. Just as the DoD uses elite Special Operations teams to pioneer new capabilities, HHS should create high-agency “SWAT teams” that experiment with novel approval models, monitor outcomes in real time using consumer tech like wearables and remote diagnostics, and publish findings transparently. Let the best frameworks rise through internal competition—not by decree, but by results.

CHAOS was born of Lyndon Johnson’s neurosis

Saturday, April 12th, 2025

Chaos by Tom O’NeillThe Church Committee looked into one of the most notorious COINTELPRO actions in L.A., Tom O’Neill explains (in Chaos: Charles Manson, the CIA, and the Secret History of the Sixties), the framing of Gerard “Geronimo” Pratt, a Black Panther and a decorated Vietnam vet:

Pratt would be imprisoned for twenty-seven years for a murder the FBI knew he didn’t commit. He was in Oakland at the time of the crime, four hundred miles away, at a Black Panther house that the Bureau had wiretapped. It had transcripts of a call he’d made to the Panther headquarters in Los Angeles just hours before the murder. Still, Bureau agents enlisted a federal informant to lie on the stand about Pratt’s involvement. Even before the frame-up, FBI gunmen had attempted to kill Pratt by shooting at him through the window of his apartment; he survived only because a spine injury he’d sustained in the war made it more comfortable to sleep on the floor.

Pratt was serving a life sentence when the Church Committee released its landmark findings, confirming what he’d long suspected: LASO and the LAPD were complicit in the COINTELPRO operation. The committee quoted a report that the FBI’s Los Angeles outpost had sent to Hoover himself, advising that “the Los Angeles [Field] Office [of the FBI] is furnishing on a daily basis information to the Los Angeles County Sheriff’s Office Intelligence Division and the Los Angeles Police Department Intelligence and Criminal Conspiracy Divisions concerning the activities of black nationalist groups in the anticipation that such information might lead to the arrest of the militants.” By the Church Committee’s estimation, this meant that Los Angeles law enforcement was guilty of obstructing justice and hindering prosecution.

In August 1967, the same month Hoover launched COINTELPRO, CIA director Richard Helms inaugurated the agency’s domestic surveillance program, CHAOS, which also infiltrated “subversive” groups and “neutralized” them:

CHAOS was born of Lyndon Johnson’s neurosis. In the summer of ’67, the president was convinced that the divided, disorderly America he led couldn’t possibly be the product of his own policies. Foreign agents, and presumably foreign money, must be to blame. He ordered the CIA to prove that the nation’s dissidents, and especially its antiwar movement, had their origins abroad.

Richard Helms complied without hesitation. In the six years that followed, the CIA tracked thousands of Americans, insulating its information gathering so thoroughly that even those at the top of its counterintelligence division were clueless about its domestic surveillance. CHAOS kept tabs on three hundred thousand people, more than seven thousand of them American citizens. The agency shared information with the FBI, the White House, and the Justice Department. At its peak, CHAOS had fifty-two dedicated agents, most of whom served to infiltrate antiwar groups, like their counterparts in the FBI. Undercover, they hoped to identify Russian instigators, although they never found any. With the Interdivision Intelligence Unit (IDIU), a new branch of the Justice Department outfitted with sophisticated computerized databases, they collaborated on a list of more than ten thousand names, all thought to be dangerous activists; the IDIU produced regular reports on these people, hoping to predict their activities.

The journalist Seymour Hersh got wind of CHAOS late in 1974. He told James Jesus Angleton, the head of CIA counterintelligence, and William Colby, the director of the CIA, that he had a story “bigger than My Lai” about CIA domestic activities. Colby was forced to admit that Hersh’s findings were accurate, and Angleton resigned from the agency. The story broke on December 22, on the front page of the New York Times: “Huge CIA Operation Reported in U.S. Against Anti-War Forces, Other Dissidents in Nixon Years.”

The Church Committee probed the CIA’s illegal activities, as did a separate government investigation, the Rockefeller Commission—but neither was able to penetrate the agency’s veil of secrecy. Since the CIA has no right to operate on American soil, the program should have brought even more censure than COINTELPRO; instead, it drew only a muted response. CIA leadership stonewalled at every opportunity. Even if they hadn’t, investigators were crippled by the dearth of information. When Richard Helms had disbanded CHAOS before leaving office in 1973, he ordered the destruction of every file pertaining to it, and since the seventies, almost nothing has come out. The operation hardly left a footprint.

[…]

In a memoir, former CIA director Colby later claimed that President Gerald Ford fired him for refusing to help Rockefeller sabotage his own investigation. According to Colby, CHAOS was so highly classified that even he, the director of the CIA, didn’t have access to it. “I found it impossible to do much about whatever was wrong with [CHAOS],” he wrote. “Its super-secrecy and extreme compartmentalization kept me very much on its periphery.”

It would be another four years before the public had any idea the F-117 Nighthawk existed

Friday, April 11th, 2025

Area 51 by Annie Jacobsen With 267 combat missions under his belt, 44 in Korea and 213 in Vietnam, Robert M. Bond was a highly decorated Air Force pilot and vice commander of Air Force Systems Command at Andrews Air Force Base, in Maryland, Annie Jacobsen explains (in Area 51), which made him a VIP when he visited the F-117 program at Area 51 in March, 1984:

But in addition to being impressed by the F-117 Nighthawk, General Bond was equally fascinated by the MiG program, which was still going on at Area 51. In the fifteen years since the CIA had gotten its hands on Munir Redfa’s MiG-21, the Agency and the Air Force had acquired a fleet of Soviet-made aircraft including an MiG-15, an MiG-17, and, most recently, the supersonic MiG-23. Barnes says, “We called it the Flogger. It was a very fast plane, almost Mach 3. But it was squirrelly. Hard to fly. It could kill you if you weren’t well trained.”

On a visit to Area 51 the following month, General Bond requested to fly the MiG-23. “There was some debate about whether the general should be allowed to fly,” Barnes explains. “Every hour in a Soviet airplane was precious. We did not have spare parts. We could not afford unnecessary wear and tear. Usually a pilot would train for at least two weeks before flying a MiG. Instead, General Bond got a briefing while sitting inside the plane with an instructor pilot saying, ‘Do this, do that.’” In other words, instead of undergoing two weeks of training, General Bond pulled rank.

General Bond’s death opened the possible exposure of five secret programs and facilities, including the MiG program, the F-117 program, Area 51, Area 52, and the nuclear reactor explosions at Jackass Flats. Unlike the deaths of CIA pilots flying out of Area 51, which could be concealed as generic training accidents, the death of a general required detailed explanation. If the press asked too many questions, it could trigger a federal investigation. One program had to come out of the dark to keep the others hidden. The Pentagon made the decision to out the MiG. Quietly, Fred Hoffman, a military writer with the Associated Press, was “leaked” information that Bond had in fact died at the controls of a Soviet MiG-23. The emphasis was put on how the Pentagon was able to obtain Soviet-bloc aircraft and weaponry from allies in Eastern Europe, the Middle East, and Asia. “The government has always been reluctant to discuss such acquisitions for fear of embarrassing the friendly donors, but the spotlight was turned anew on the subject after a three-star Air Force general was killed April 26 in a Nevada plane crash that was quickly cloaked in secrecy,” Hoffman wrote, adding “sources who spoke on condition they remain anonymous have indicated the MiG-23, the most advanced Soviet warplane ever to fall permanently into U.S. hands, was supplied to this country by Egypt.”

[…]

It would be another four years before the public had any idea the F-117 Nighthawk existed. In November of 1988, a grainy image of the arrowhead-shaped, futuristic-looking craft was released to an awestruck public despite the fact that variations of the F-117 had been flying at Area 51 and Area 52 for eleven years.

Recent excavations turned up only a dozen corpses and a couple of guns

Thursday, April 10th, 2025

Napoleon by Andrew RobertsAndrew Roberts dispels a myth (in Napoleon: A Life) about the Battle of Austerlitz:

Buxhöwden’s Russian force was split in two and fled east of the frozen lakes and across them, whereupon Napoleon had his gunners open fire on the ice. This incident led to the myth that thousands of Russians drowned as the ice cracked, though recent excavations of the reclaimed land at Lake Satschan turned up only a dozen corpses and a couple of guns.

The modern world, for better or worse, springs from Europe

Wednesday, April 9th, 2025

Prisoners of Geography by Tim MarshallThe modern world, for better or worse, Tim Marshall explains (in Prisoners of Geography: Ten Maps That Explain Everything About the World), springs from Europe:

This western outpost of the great Eurasian landmass gave birth to the Enlightenment, which led to the Industrial Revolution, which has resulted in what we now see around us every day.

[…]

The climate, fed by the Gulf Stream, blessed the region with the right amount of rainfall to cultivate crops on a large scale, and the right type of soil for them to flourish in. This allowed for population growth in an area in which, for most, work was possible year-round, even in the height of summer. Winter actually adds a bonus, with temperatures warm enough to work in but cold enough to kill off many of the germs, which to this day plague huge parts of the rest of the world.

[…]

Western Europe has no real deserts, the frozen wastes are confined to a few areas in the far north, and earthquakes, volcanoes, and massive flooding are rare. The rivers are long, flat, navigable, and made for trade. As they empty into a variety of seas and oceans, they flow into coastlines that are—west, north, and south—abundant in natural harbors.

[…]

The various tribes of the Iberian Peninsula, for example, prevented from expanding north into France by the presence of the Pyrenees, gradually came together, over thousands of years, to form Spain and Portugal—and even Spain is not an entirely united country, with Catalonia increasingly vocal about wanting its independence. France has also been formed by natural barriers, framed as it is by the Pyrenees, the Alps, the Rhine, and the Atlantic Ocean.

Europe’s major rivers do not meet (unless you count the Sava, which drains into the Danube in Belgrade). This partly explains why there are so many countries in what is a relatively small space. Because they do not connect, most of the rivers act, at some point, as boundaries, and each is a sphere of economic influence in its own right; this gave rise to at least one major urban development on the banks of each river, some of which in turn became capital cities.

Europe’s second longest river, the Danube (1,771 miles), is a case in point. It rises in Germany’s Black Forest and flows south on its way to the Black Sea. In all, the Danube basin affects eighteen countries and forms natural borders along the way, including those of Slovakia and Hungary, Croatia and Serbia, Serbia and Romania, and Romania and Bulgaria. More than two thousand years ago it was one of the borders of the Roman Empire, which in turn helped it to become one of the great trading routes of medieval times and gave rise to the present capital cities of Vienna, Bratislava, Budapest, and Belgrade. It also formed the natural border of two subsequent empires, the Austro-Hungarian and the Ottoman.

[…]

The countries of northern Europe have been richer than those of the south for several centuries. The north industrialized earlier than the south and so has been more economically successful. As many of the northern countries comprise the heartland of Western Europe, their trade links were easier to maintain, and one wealthy neighbor could trade with another—whereas the Spanish, for example, either had to cross the Pyrenees to trade, or look to the limited markets of Portugal and North Africa.

[…]

There are also unprovable theories that the domination of Catholicism in the south has held it back, whereas the Protestant work ethic propelled the northern countries to greater heights. Each time I visit the Bavarian city of Munich, I reflect on this theory, and while driving past the gleaming temples of the headquarters of BMW, Allianz, and Siemens I have cause to doubt it. In Germany, 34 percent of the population is Catholic, and Bavaria itself is predominantly Catholic, yet their religious predilections do not appear to have influenced either their progress or their insistence that Greeks work harder and pay more taxes.

[…]

France is the only European country to be both a northern and southern power. It contains the largest expanse of fertile land in Western Europe, and many of its rivers connect with one another; one flows west all the way to the Atlantic (the Seine), another south to the Mediterranean (the Rhône). These factors, together with France’s relative flatness, were suitable for the unification of regions, and—especially from the time of Napoleon—centralization of power.

[…]

The south of Italy, for example, is still well behind the north in terms of development, and although it has been a unified state (including Venice and Rome) since 1871, the strains of the rift between north and south are greater now than they have been since before the Second World War. The heavy industry, tourism, and financial centers of the north have long meant a higher standard of living there, leading to the formation of political parties agitating for cutting state subsidies to the south, or even breaking away from it.

Spain is also struggling, and has always struggled because of its geography. Its narrow coastal plains have poor soil, and access to markets is hindered internally by its short rivers and the Meseta Central, a highland plateau surrounded by mountain ranges, some of which cut through it. Trade with Western Europe is further hampered by the Pyrenees, and any markets to its south on the other side of the Mediterranean are in developing countries with limited income. It was left behind after the Second World War, as under the Franco dictatorship it was politically frozen out of much of modern Europe. Franco died in 1975 and the newly democratic Spain joined the EU in 1986. By the 1990s, it had begun to catch up with the rest of Western Europe, but its inherent geographical and financial weaknesses continue to hold it back and have intensified the problems of overspending and loose central fiscal control. It has been among the countries hit worst by the 2008 economic crisis.

[…]

Much of the Greek coastline comprises steep cliffs and there are few coastal plains for agriculture. Inland are more steep cliffs, rivers that will not allow transportation, and few wide, fertile valleys. What agricultural land there is is of high quality; the problem is that there is too little of it to allow Greece to become a major agricultural exporter, or to develop more than a handful of major urban areas containing highly educated, highly skilled, and technologically advanced populations. Its situation is further exacerbated by its location, with Athens positioned at the tip of a peninsula, almost cut off from land trade with Europe. It is reliant on the Aegean Sea for access to maritime trade in the region—but across that sea lies Turkey, a large potential enemy.

[…]

It didn’t take long for people in Germany to point out that they were working until sixty-five but paying taxes that were going to Greece so that people could retire at fifty-five. They then asked “Why?” And the answer, “In sickness and in health,” was unsatisfactory.

[…]

The trauma of two world wars, followed by seven decades of peace and then the collapse of the Soviet Union persuaded many people that Western Europe was a “post-conflict” region.

[…]

The corridor of the North European Plain is at its narrowest between Poland’s Baltic coast in the north and the beginning of the Carpathian Mountains in the south. This is where, from a Russian military perspective, the best defensive line could be placed or, from an attacker’s viewpoint, the place at which its forces would be squeezed together before breaking out toward Russia.

The Poles have seen it both ways, as armies have swept east and west across it, frequently changing borders. If you take The Times Atlas of European History and flick through the pages quickly as if it were a flip book, you see Poland emerge circa 1000 CE, then continually change shape, disappear, and reappear until assuming its present form in the late twentieth century.

[…]

In 1999, Poland joined NATO, extending the Alliance’s reach four hundred miles closer to Moscow. By then, several other former Warsaw Pact countries were also members of the Alliance, and in 1999 Moscow watched helplessly as NATO went to war with its ally, Serbia. In the 1990s, Russia was in no position to push back, but after the chaos of the Yeltsin years, Putin stepped in on the front foot and came out swinging.

[…]

Denmark is already a NATO member, and the recent resurgence of Russia has caused a debate in Sweden over whether it is time to abandon the neutrality of two centuries and join the Alliance. In 2013, Russian jets staged a mock bombing run on Sweden in the middle of the night. The Swedish defense system appears to have been asleep, failing to scramble any jets, and it was the Danish air force that took to the skies to shepherd the Russians away. Despite that, the majority of Swedes remain against NATO membership, but the debate is ongoing, informed by Moscow’s statement that it would be forced to “respond” if either Sweden or Finland were to join the Alliance.

[…]

What is now the EU was set up so that France and Germany could hug each other so tightly in a loving embrace that neither would be able to get an arm free with which to punch the other. It has worked brilliantly and created a huge geographical space now encompassing the biggest economy in the world.

[…]

The Germans were involved in the machinations that overthrew Ukraine’s President Yanukovych in 2014 and they were sharply critical of Russia’s subsequent annexation of Crimea. However, mindful of the gas pipelines, Berlin was noticeably more restrained in its criticism and support for sanctions than, for example, the UK, which is far less reliant on Russian energy.

[…]

Geographically, the Brits are in a good place. Good farmland, decent rivers, excellent access to the seas and their fish stocks, close enough to the European continent to trade, and yet protected by dint of being an island race—there have been times when the UK gave thanks for its geography as wars and revolutions swept over its neighbors.

[…]

There is a theory that the relative security of the UK over the past few hundred years is why it has experienced more freedom and less despotism than the countries across the channel. The theory goes that there were fewer requirements for “strong men” or dictators, which, starting with the Magna Carta (1215) and then the Provisions of Oxford (1258), led to forms of democracy years ahead of other countries.

[…]

Its location still grants it certain strategic advantages, one of which is the GIUK gap. This is a choke point in the world’s sea-lanes—it is hardly as important as the Strait of Hormuz or the Strait of Malacca, but it has traditionally given the UK an advantage in the North Atlantic.

[…]

The GIUK is one of many reasons why London flew into a panic in 2014 when, briefly, the vote on Scottish independence looked as if it might result in a yes. The loss of power in the North Sea and North Atlantic would have been a strategic blow to and a massive dent in the prestige of whatever was left of the UK.

[…]

Prejudice against immigrants always rises during times of economic recession such as recently suffered in Europe, and the effects have been seen across the continent and have resulted in the rise of right-wing political parties, all of which militate against pan-nationalism and thus weaken the fabric of the EU. A stark example came in early 2016 when for the first time in half a century, Sweden began checking the documents of travelers from Denmark. This was a direct response to the waves of refugees and migrants flowing into northern Europe from the wider Middle East and the ISIS attacks on Paris in December 2015. The idea of the EU’s “Schengen Area,” a border-free area composed of twenty-six countries, has taken some heavy blows with different countries, at different times, reintroducing border controls on the grounds of security.

“All-Ukrainian” FPV drones?

Tuesday, April 8th, 2025

Last month, Ukrainian makers Vyriy Drone performed an official handover of the first batch of 1,000 “all-Ukrainian” FPV drones:

It is important to note that some of the electronic chips in that make up devices may in fact come from China or other countries. But these are simple building blocks, commodity products which can be sourced from the U.S. and Japan. They are very different to specialist end products for drones like flight controllers.

[…]

“Initially, there was a generally accepted opinion that China could not be beaten on price,” Ukrainian analyst Serhii Flash wrote on his Telegram channel. “Never. But competition, time, volumes, optimization of business processes work wonders.”

Flash shares a graph showing how the prices of various locally made components including motors, frames and propellers have dropped an average of around 50% over the last two years.

Frames and propellers are relatively easy to make without a major investment in production machinery. Other components are more challenging. In 2024 we reported on how Ukrainian makers Wild Hornets were making their own flight controllers on a robotic assembly line, and later set up a similar process to make their own drone batteries.

Specialist companies have gone further. Thermal imagers are a particular challenge, and FPV makers have spent considerable time and effort finding Chinese suppliers who meet their requirements for cost and capability. In other countries, the defence sector makes it own high-end thermal imagers and price is not a factor. Drone makers are on a tighter budget. A $2,000 military imager is not a viable proposition for a $400 FPV,

In October 2024 Ukrainian start-up Odd Systems announced that they were producing locally-made thermal imagers. These are comparable to Chinese 256×192 pixel imagers, but about 20% cheaper at $250. Odd Systems say they when they can make their Kurbas-256 in volume the unit price will drop even further.

Importantly the Kurbas-256 is designed for FPVs rather than general industrial use. The developers talked to users about their combat experience with commercial Chinese thermal imaging cameras and modified their design accordingly. For example, some Chinese cameras suffer from condensation forming inside them, making them unusable, so Kurbas cameras come in a sealed unit sealed to prevent condensation.

“We studied the experience and considered the wishes of FPV operators. We have created a Ukrainian product with full control of hardware and low-level software,” the company told Militaryni.

For example, the operator can adjust the output of the Kurbas-256 in flight, changing contrast for a clearer image depending on conditions. Also, most thermal cameras have automatic calibration which sometimes freezes the image for several seconds. This is not an issue for most applications but disastrous on a drone, so Odd Systems’ cameras do not have this ‘feature’.

The Return of the Dire Wolf?

Monday, April 7th, 2025

Time magazine announces the return of the dire wolf:

The dire wolf once roamed an American range that extended as far south as Venezuela and as far north as Canada, but not a single one has been seen in over 10,000 years, when the species went extinct. Plenty of dire wolf remains have been discovered across the Americas, however, and that presented an opportunity for a company named Colossal Biosciences.

Relying on deft genetic engineering and ancient, preserved DNA, Colossal scientists deciphered the dire wolf genome, rewrote the genetic code of the common gray wolf to match it, and, using domestic dogs as surrogate mothers, brought Romulus, Remus, and their sister, 2-month-old Khaleesi, into the world during three separate births last fall and this winter—effectively for the first time de-extincting a line of beasts whose live gene pool long ago vanished. TIME met the males (Khaleesi was not present due to her young age) at a fenced field in a U.S. wildlife facility on March 24, on the condition that their location remain a secret to protect the animals from prying eyes.

The dire wolf isn’t the only animal that Colossal, which was founded in 2021 and currently employs 130 scientists, wants to bring back. Also on their de-extinction wish list is the woolly mammoth, the dodo, and the thylacine, or Tasmanian tiger. Already, in March, the company surprised the science community with the news that it had copied mammoth DNA to create a woolly mouse, a chimeric critter with the long, golden coat and the accelerated fat metabolism of the mammoth.

If all this seems to smack of a P.T. Barnum, the company has a reply. Colossal claims that the same techniques it uses to summon back species from the dead could prevent existing but endangered animals from slipping into extinction themselves.

[…]

It takes surprisingly few genetic changes to spell the difference between a living species and an extinct one. Like other canids, a wolf has about 19,000 genes. (Humans and mice have about 30,000.) Creating the dire wolves called for making just 20 edits in 14 genes in the common gray wolf, but those tweaks gave rise to a host of differences, including Romulus’ and Remus’ white coat, larger size, more powerful shoulders, wider head, larger teeth and jaws, more-muscular legs, and characteristic vocalizations, especially howling and whining.
The dire wolf genome analyzed to determine what those changes were was extracted from two ancient samples—one a 13,000-year-old tooth found in Sheridan Pit, Ohio, the other a 72,000-year-old ear bone unearthed in American Falls, Idaho.

[…]

Colossal’s dire wolf work took a less invasive approach, isolating cells not from a tissue sample of a donor gray wolf, but from its blood. The cells they selected are known as endothelial progenitor cells (EPCs), which form the lining of blood vessels. The scientists then rewrote the 14 key genes in the cell’s nucleus to match those of the dire wolf; no ancient dire wolf DNA was actually spliced into the gray wolf’s genome. The edited nucleus was then transferred into a denucleated ovum. The scientists produced 45 engineered ova, which were allowed to develop into embryos in the lab. Those embryos were inserted into the wombs of two surrogate hound mixes, chosen mostly for their overall health and, not insignificantly, their size, since they’d be giving birth to large pups. In each mother, one embryo took hold and proceeded to a full-term pregnancy. (No dogs experienced a miscarriage or stillbirth.) On Oct. 1, 2024, the surrogates birthed Romulus and Remus. A few months later, Colossal repeated the procedure with another clutch of embryos and another surrogate mother. On Jan. 30, 2025, that dog gave birth to Khaleesi.

[…]

“The idea that we could just take a vial of blood, isolate EPCs, culture them, and clone from them, and they have a pretty high cloning efficiency, we think it’s a game changer,” says George Church, Colossal co-founder, and professor of genetics at both Harvard University and the Massachusetts Institute of Technology. The less invasive cell-sampling process will make the procedure easier on animals, and the fact that Colossal’s methods worked on this early go-round boosts company confidence that they are on track for much broader de-extinction and rewilding.

Borrowing a name from Game of Thrones for a dire wolf makes perfect sense, but Khaleesi? The actual (fictional) dire wolves in the stories are:

Grey Wind, adopted by Robb Stark.
Lady, adopted by Sansa Stark.
Nymeria, adopted by Arya Stark.
Shaggydog, adopted by Rickon Stark.
Summer, adopted by Bran Stark.
Ghost, adopted by Jon Snow.

Scientific purists will note that the “dire wolves” created by Colossal are merely ordinary wolves with a few gene edits. Previous “dire wolves” have been dogs bred to look like wolves.

Artificial sweetener shows surprising power to overcome antibiotic resistance

Sunday, April 6th, 2025

Professor Ronan McCarthy, at Brunel University of London’s Antimicrobial Innovations Center, and his team have found that saccharin shows surprising power to overcome antibiotic resistance:

“Saccharin breaks the walls of bacterial pathogens, causing them to distort and eventually burst, killing the bacteria. Crucially, this damage lets antibiotics slip inside, overwhelming their resistance systems.”

[…]

The international team found that saccharin both stops bacterial growth and disrupts DNA replication and stops the bacteria from forming biofilms—sticky, protective layers that help them survive antibiotics.

They also created a saccharin-loaded hydrogel wound dressing that, in tests, outperformed market-leading silver-based antimicrobial dressings currently used in hospitals.

“This is very exciting,” Prof McCarthy added. “Normally it takes billions of dollars and decades to develop a new antibiotic. But here we have a compound that’s already widely used, and it not only kills drug-resistant bacteria but also makes existing antibiotics more effective.

“Artificial sweeteners are found in many diet and sugar-free foods. We discovered that the same sweeteners you have with your coffee or in a ‘sugar-free’ drink could make some of the world’s most dangerous bacteria easier to treat.”

What does saccharin do to benign bacteria?

Two years later, the Panthers had become almost synonymous with Hollywood’s liberal elite

Saturday, April 5th, 2025

Chaos by Tom O’NeillWhen Hoover reconstituted COINTELPRO, Tom O’Neill explains (in Chaos: Charles Manson, the CIA, and the Secret History of the Sixties), he was already worried that America’s black militants would be embraced by liberal whites, especially in a left-leaning place like Hollywood:

In the August 1967 memo reanimating the counterintelligence program, he’d noted the importance of “prevent[ing] militant Black Nationalist groups and leaders from gaining respectability”: “they must be discredited to the white community, both the responsible community and to the ‘liberals’ who have vestiges of sympathy for militant black nationalists simply because they are Negroes.”

Two years later, the Panthers had become almost synonymous with Hollywood’s liberal elite. Actresses such as Jane Fonda and Jean Seberg appeared at their rallies. Hoover felt he had to widen the chasm between blacks and whites in Los Angeles. In a November 1968 memo, an L.A. field agent discussed new efforts to spread disinformation to Hollywood’s liberal whites.

In the context of the Tate–LaBianca murders, the memo is chilling. Remember, the Tate house by then had become a high-profile gathering place for liberal Hollywood—among others, for Fonda, Cass Elliot, and Warren Beatty, all three of whom were under FBI surveillance. Abigail Folger, who would die at the hands of the Family, was an outspoken civil rights activist. That year she campaigned for Tom Bradley, the first African American candidate for mayor of Los Angeles. Many in the Polanski–Tate crowd belonged to the White Panther party, explicit allies of the Black Panthers, or to the Peace and Freedom Party of California, which also voiced its support. The FBI, according to the memo, planned to generate distrust through disinformation:

The Peace and Freedom Party (PFP) has been furnishing the BPP with financial assistance. An anonymous letter is being prepared for Bureau approval to be sent to a leader of PFP in which it is set forth that the BPP has made statements in closed meetings that when the armed rebellion comes the whites in the PFP will be lined up against the wall with the rest of the whites.

[…]

Less than a year after this memo was written, Manson’s followers lined up four denizens of liberal Hollywood in Roman Polanski’s home and cut them to pieces, leaving slogans in blood to implicate the Black Panthers.

How many targets can we take out on a single sortie?

Friday, April 4th, 2025

Area 51 by Annie JacobsenThe F-117 Nighthawk, the nation’s first stealth bomber, would radically change the way America fought wars, Annie Jacobsen explains (in Area 51):

As a Lockheed official explained at a banquet honoring the F-117 in April of 2008, “Before the advent of stealth, war planners had to determine how many sorties were necessary to take out a single target. After the invention of the F-117 stealth bomber, that changed. It became, How many targets can we take out on a single sortie?”

Lockheed physicist Edward Lovick worked on each rendition of the stealth bomber, which began in the early 1970s with Harvey, a prototype aircraft named after the Jimmy Stewart film about an invisible rabbit. Harvey’s stealth qualities were initially engineered using slide rules and calculators, the same way Lockheed had developed the A-12 Oxcart. Only with the emergence of the mainframe computer, in 1974, did those tools become obsolete. “Two Lockheed engineers, named Denys Overholser and Dick Scherrer, realized that it might be possible to design a stealth aircraft that would take advantage of some of the results of a computer’s calculations,” Lovick says. “In 1974 computers were relatively new and most of them were the size of a car. Our computer at Lockheed ran on punch cards and had less than 60 K worth of memory.” Still, the computer could do what humans could not do, and that was endless calculations.

[…]

“We designed flat, faceted panels and had them act like mirrors to scatter radar waves away from the plane,” Lovick says. “It was a radical idea and it worked.”

The next, on-paper incarnation of the F-117 Nighthawk began in 1974 and was called the Hopeless Diamond, so named because it resembled the Hope Diamond and because Lockheed engineers didn’t have much hope it would actually fly. After the Hopeless Diamond concept went through a series of redesigns it became a full-scale mock-up of an aircraft and was renamed Have Blue.

[…]

“It was a very weird, very crude-looking thing that actually looked a lot like the ship from Twenty Thousand Leagues Under the Sea. Our job was to look at it from every angle using radar to see how it showed up on radar.”

[…]

“Initially, it was as visible as a big old barn,” says Barnes. So the Have Blue mock-up was sent back to the Skunk Works for more fine-tuning. Several months later, a new version of the mock-up arrived at Area 51. “Lockheed had changed the shape of the aircraft and a lot of the angles of the panels. Once we put the new mock-up on the pole it appeared to us as something around the size of a crow.” There was a final round of redesigns, then the airplane came back to Area 51 again. “We put it up on the pole and all we saw was the pole.”

[…]

The director of science and engineering at Skunk Works, a man named Ed Martin, went to Lovick for some advice. “Ed Martin asked me how I thought the aircraft might appear on enemy radar. I explained that if the Oxcart showed up as being roughly equivalent to the size of a man, the Have Blue would appear to a radar like a seven-sixteenth-inch metal sphere — roughly the size of a ball bearing.” Ed Martin loved Lovick’s analogy. A ball bearing.

[…]

Before Martin left for Washington, DC, Lovick went to the Lockheed tool shop and borrowed a bag of ball bearings. He wanted Ed Martin to have a visual reference to share with the Air Force officials there. “Later, I learned the ball-bearing illustration was so effective that the customers began rolling the little silvery spheres across the conference table. The analogy has become legendary, often still used to make an important visual point about the stealthy F-117 Nighthawk with its high-frequency radar signature that is as tiny as a ball bearing.”

Napoleon was master in Europe, but he was also a prisoner there

Thursday, April 3rd, 2025

Napoleon by Andrew RobertsThe victory at Trafalgar allowed Britain to step up its economic war against France, Andrew Roberts explains (in Napoleon: A Life), and to impose a blockade of the entire European coast from Brest to the Elbe:

As the philosopher Bertrand de Jouvenel put it, ‘Napoleon was master in Europe, but he was also a prisoner there.’

[…]

Instead of now abandoning his invasion dreams entirely, Napoleon continued to spend huge amounts of money, time and energy trying to rebuild a fleet that he believed could threaten Britain again through sheer numbers. He never understood that a fleet which spent seven-eighths of its time in port simply could not gain the seamanship necessary to take on the Royal Navy at the height of its operational capacity.

While a conscript in the Grand Armée could be — indeed very often was — trained in drill and musketry while on the march to the front, sailors couldn’t be taught on land how to deal with top-hamper lost in a gale, or to fire off more than one broadside in a rolling sea against an opponent who had been trained to fire two or even three in the same length of time.

Why go to Latin America and be a serf, when you could go to the United States and be a free land-owning man?

Wednesday, April 2nd, 2025

Prisoners of Geography by Tim MarshallIf you won the lottery, and were looking to buy a country to live in, Tim Marshall explains (in Prisoners of Geography: Ten Maps That Explain Everything About the World), the first one the real estate agent would show you would be the United States of America:

First, there is the East Coast Plain leading to the Appalachian Mountains, an area well watered by short but navigable rivers and with fertile soil. Then, heading farther west, you have the Great Plains stretching all the way to the Rocky Mountains, and within this section lies the Mississippi basin with its network of huge, navigable rivers flowing into the Mississippi River all the way down to the Gulf of Mexico, which is sheltered by the peninsula of Florida and several islands. Once over the massive mountain range that is the Rockies you get to the desert, the Sierra Nevada Mountains, a narrow coastal plain, and finally to the shores of the Pacific Ocean.

To the north, above the Great Lakes, lies the Canadian Shield, the world’s largest area of Precambrian rock, much of which forms a barrier to human settlement. To the southwest—desert.

[…]

The last of the original thirteen colonies to be established was Georgia in 1732. The thirteen became increasingly independent minded all the way up to the American Revolutionary War (1775–83). At the beginning of this period, the colonies, which gradually began to connect to one another, stretched one thousand miles from Massachusetts in the north, down to Georgia, and had an estimated combined population of approximately 2.5 million people. They were bounded by the Atlantic to their east and the Appalachian Mountains to their west. The Appalachians, 1,500 miles long, are impressive, but compared to the Rockies not particularly high.

[…]

The British government forbade settlement west of the Appalachians, as it wanted to ensure that trade, and taxes, remained on the Eastern Seaboard.

[…]

In the early 1800s this new country’s leadership still had little idea that it was thousands of miles from the “south sea,” or Pacific. Using Native American trails, a few explorers, for whom the word intrepid could have been coined, had pushed through the Appalachians and reached the Mississippi. There they thought they might find a waterway leading to the ocean and thus joining up with the vast tracts of lands the Spanish had explored across the southwestern and Pacific coastal regions, including what are now Texas and California.

[…]

Its citizens already had access to the Ohio River, just west of the Appalachians, but that led to the Mississippi, whose western bank was controlled by the French all the way down to the city of New Orleans. This gave the French command of American trade heading out to the Old World from the Gulf of Mexico, as well as the vast territory to the west in what is now the American heartland. In 1802, a year after Thomas Jefferson assumed the presidency, he wrote: “There is on the globe one single spot, the possessor of which is our natural and habitual enemy. It is New Orleans.”

[…]

The greater Mississippi basin has more miles of navigable river than the rest of the world put together. Nowhere else are there so many rivers whose source is not in highland and whose waters run smoothly all the way to the ocean across vast distances. The Mississippi, fed by much of the basin river system, begins near Minneapolis and ends 1,800 miles south in the Gulf of Mexico. So the rivers were the natural conduit for ever-increasing trade, leading to a great port and all using waterborne craft that was, and is, many times cheaper than road travel.

The Americans now had strategic geographical depth, a massive fertile land, and an alternative to the Atlantic ports with which to conduct business. They also had ever-expanding routes east to west linking the East Coast to the new territory, and then the river systems flowing north to south to connect the then sparsely populated lands with one another, thus encouraging America to form as a single entity.

[…]

In 1819 the Spanish ceded Florida to the United States and with it a massive amount of territory.

[…]

Mexico controlled land all the way up to Northern California, which the United States could live with, but it also stretched out east, including what is now Texas, which, then as now, borders Louisiana. Mexico’s population at the time was 6.2 million, the United States’s 9.6 million. The US army may have been able to see off the mighty British, but they had been fighting three thousand miles from home with supply lines across an ocean. The Mexicans were next door.

[…]

Mexico is not blessed in the American way. It has poor-quality agricultural land, no river system to use for transport, and was wholly undemocratic, with new arrivals having little chance of ever being granted land.

[…]

By the mid-1830s there were enough white settlers in Texas to force the Mexican issue. The Mexican, Catholic, Spanish-speaking population numbered in the low thousands, but there were approximately twenty thousand white Protestant settlers. The Texas Revolution of 1835–36 drove the Mexicans out, but it was a close-run thing, and had the settlers lost then, the Mexican army would have been in a position to march on New Orleans and control the southern end of the Mississippi. It is one of the great what-ifs of modern history.

However, history turned the other way and Texas became independent, via American money, arms, and ideas. The territory went on to join the Union in 1845 and together they fought the 1846–48 Mexican War, in which they crushed their southern neighbor, which was required to accept that Mexico ended in the sands of the southern bank of the Rio Grande.

[…]

In the south, the Rio Grande runs through desert; to the north are the Great Lakes and rocky land with few people close to the border, especially in the eastern half of the continent; and to the east and west are the great oceans. However, in the twenty-first century, in the southwest the cultural historical memory of the region as Hispanic land is likely to resurface, as the demographics are changing rapidly and Hispanics will be the majority population within a few decades.

[…]

The Homestead Act of 1862 awarded 160 acres of federally owned land to anyone who farmed it for five years and paid a small fee. If you were a poor man from Germany, Scandinavia, or Italy, why go to Latin America and be a serf, when you could go to the United States and be a free land-owning man?

In 1867, Alaska was bought from Russia. At the time it was known as “Seward’s Folly,” named for the secretary of state, William Seward, who agreed to the deal. He paid $ 7.2 million, or two cents, an acre. The press accused him of purchasing snow, but minds were changed with the discovery of gold in 1896. Decades later, huge reserves of oil were also found.

Two years on, in 1869, came the opening of the transcontinental railroad. Now you could cross the country in a week, whereas it had previously taken several hazardous months.

[…]

The only real threat was from Spain—it may have been persuaded to leave the mainland, but it still controlled the islands of Cuba, Puerto Rico, and part of what is now the Dominican Republic.

Cuba in particular kept American presidents awake at night, as it would again in 1962 during the Cuban Missile Crisis. The island sits just off Florida, giving it access to and potential control of the Straits of Florida and the Yucatán Channel in the Gulf of Mexico. This is the exit and entry route for the port of New Orleans.

[…]

In 1898, the US declared war on Spain, routed its military, and gained control of Cuba, with Puerto Rico, Guam, and the Philippines thrown in for good measure. They would all come in useful, but Guam in particular is a vital strategic asset and Cuba a strategic threat if controlled by a major power.

[…]

In the same year it secured Cuba, the Straits of Florida, and to a great extent the Caribbean. It also annexed the Pacific island of Hawaii, thus protecting the approaches to its own West Coast. In 1903, America signed a treaty leasing it exclusive rights to the Panama Canal. Trade was booming.

[…]

Sixteen navy battleships from the Atlantic force set out from the United States in December 1907. Their hulls were painted white, the navy’s peacetime color, and this impressive example of diplomatic signaling became known as “the Great White Fleet.” Over the following fourteen months the fleet called on twenty ports, including ones in Brazil, Chile, Mexico, New Zealand, Australia, the Philippines, Japan, China, Italy, and Egypt. Of these the most important was Japan, who was put on notice that in extremis America’s Atlantic fleet could be deployed to the Pacific. The voyage, a mixture of hard and soft power, preceded the military term force projection, but that is what it was, and it was duly noted by every major power in the world.

[…]

In the autumn of 1940, the British desperately needed more warships. The Americans had fifty to spare and so, with what was called the Destroyers for Bases Agreement, the British swapped their ability to be a global power for help in remaining in the war. Almost every British naval base in the Western Hemisphere was handed over.

[…]

In 1949, Washington led the formation of NATO and with it effectively assumed command of the Western world’s surviving military might. The civilian head of NATO may well be a Belgian one year, a Brit the next, but the military commander is always an American, and by far the greatest firepower within NATO is American.

No matter what the treaty says, NATO’s Supreme Commander ultimately answers to Washington. The UK and France would learn at their expense during the Suez Crisis of 1956—when they were compelled by American pressure to cease their occupation of the canal zone, losing most of their influence in the Middle East as a result—that a NATO country does not hold a strategic naval policy without first asking Washington.

With Iceland, Norway, Britain, and Italy (all founding members of NATO) having granted the United States access and rights to their bases, it now dominated the North Atlantic and the Mediterranean as well as the Pacific. In 1951, it extended its domination there down to the south by forming an alliance with Australia and New Zealand, and also to the north following the Korean War of 1950–53.

There were now two maps of the United States. The familiar one stretching diagonally down from Seattle on the Pacific coast to the panhandle in the Sargasso Sea, and the part real/ part conceptual one of America’s geopolitical-power footprint.

[…]

There were now only three places from which a challenge to American hegemony could come: a united Europe, Russia, and China. All would grow stronger, but two would reach their limits.

The dream of some Europeans of an EU with “ever closer union” and a common foreign and defense policy is dying slowly before our eyes, and even if it were not, the EU countries spend so little on defense that ultimately they remain reliant on the United States. The economic crash of 2008 has left the European powers reduced in capacity and with little appetite for foreign adventures. The gradual splintering of the idea of unity was magnified by the UK’s decision to hold a referendum on its membership in the EU in the summer of 2016. The complicated aftermath of the Brexit vote has brought confusion to the continent. It also disappointed Washington, DC, which always favored having the UK inside the EU as its eyes and ears

In 1991, the Russian threat had been seen off due to their own staggering economic incompetence, military overstretch, and failure to persuade the subjected masses in their empire that gulags and the overproduction of state-funded tractors was the way ahead. The recent pushback by Putin’s Russia is a thorn in America’s side, but not a serious threat to America’s dominance. When President Obama described Russia as “no more than a regional power” in 2014, he may have been needlessly provocative, but he wasn’t wrong. The bars of Russia’s geographical prison, as seen in chapter one, are still in place: they still lack a warm-water port with access to the global sea-lanes and still lack the military capacity in wartime to reach the Atlantic via the Baltic and North Seas, or the Black Sea and the Mediterranean.

The United States was partially behind the change of government in Ukraine in 2014. It wanted to extend democracy in the world, and it wanted to pull Ukraine away from Russian influence and thus weaken President Putin. Washington knows that during the last decade, as America was distracted in Iraq and Afghanistan, the Russians took advantage in what they call their “near abroad,” regaining a solid footing in places such as Kazakhstan and seizing territory in Georgia. Belatedly, and somewhat half-heartedly, the Americans have been trying to roll back Russian gains.

[…]

Economically the Chinese are on their way to matching the Americans, and that buys them a lot of influence and a place at the top table, but militarily and strategically they are decades behind. The United States will spend those decades attempting to ensure it stays that way, but it feels inevitable that the gap will close.

[…]

For example, Washington might be outraged at human rights abuses in Syria (a hostile state) and express its opinions loudly, but its outrage at abuses in Bahrain might be somewhat more difficult to hear, muffled as it has been by the engines of the US 5th Fleet, which is based in Bahrain as the guest of the Bahraini government.

[…]

Many US government foreign policy strategists are persuaded that the history of the twenty-first century will be written in Asia and the Pacific. Half of the world’s population lives there, and if India is included it is expected to account for half of the global economic output by 2050.

[…]

The Cuban Missile Crisis is generally considered an American victory; what is less publicized is that several months after Russia removed its missiles from Cuba, the United States removed its Jupiter missiles (which could reach Moscow) from Turkey. It was actually a compromise, with both sides, eventually, able to tell their respective publics that they had not capitulated.

In the twenty-first-century Pacific there are more great-power compromises to be made. In the short term, most, but not all, are likely to be made by the Chinese—an early example is Beijing’s declaration of an Air Defense Identification Zone requiring foreign nations to inform them before entering what is disputed territory, and the Americans deliberately flying through it without telling them. The Chinese gained something by declaring the zone and making it an issue; the United States gained something by being seen not to comply. It is a long game. It is also a game of cat and mouse. In early 2016, for the first time, China landed a plane on one of the runways it has constructed on the artificial islands it is building in the Spratly Islands area of the South China Sea. Vietnam and the Philippines made formal protests as they both have claims on the area and the US described the move as threatening “regional stability.” Washington, DC, now watches each construction project, and flight, and has to pick and choose when and where it makes more vigorous protests or sends naval and air force patrols near the disputed territory. Somehow it must reassure its allies it will stand by them and guarantee freedom of navigation in international areas, while simultaneously not going so far as to draw China into a military confrontation.

[…]

While all the other countries in the region matter, in what is a complicated diplomatic jigsaw puzzle, the key states look to be Indonesia, Malaysia, and Singapore. These three sit astride the narrow Strait of Malacca. Every day through that strait come 12 million barrels of oil heading for an increasingly thirsty China and elsewhere in the region. As long as these three countries are pro-American, the Americans have a key advantage.

On the plus side, the Chinese are not politically ideological, they do not seek to spread Communism, nor do they covet (much) more territory in the way the Russians did during the Cold War, and neither side is looking for conflict.Due to offshore drilling in US coastal waters, and underground fracking across huge regions of the country, America looks destined to become not just self-sufficient in energy, but a net exporter of energy by 2020. This will mean that its focus on ensuring a flow of oil and gas from the Gulf region will diminish. It will still have strategic interests there, but the focus will no longer be so intense. If the American attention wanes, the Gulf nations will seek new alliances. One candidate will be Iran, another China, but that will only happen when the Chinese have built their blue-water navy and, equally important, are prepared to deploy it.

[…]

Elsewhere in the Middle East, US policy in the short term is to attempt to ensure Iran does not become too strong, but at the same time build on that nuclear deal to try and reach what is known as the “grand bargain”—an agreement settling the many issues that divide the two countries, and ending three and a half decades of enmity. With the Arab nations embarking on what may be a decades-long struggle with armed Islamists, Washington looks as if it has given up on the optimistic idea of encouraging Jeffersonian democracies to emerge and will concentrate on attempting to manage the situation, while at the same time desperately trying not to get sand on the boots of US soldiers.

The close relationship with Israel may cool, albeit slowly, as the demographics of the United States change. The children of the Hispanic and Asian immigrants now arriving in the United States will be more interested in Latin America and the Far East than in a tiny country on the edge of a region no longer vital to American interests.

The policy in Latin America will be to ensure that the Panama Canal remains open, to inquire about the rates to pass through the proposed Nicaraguan canal to the Pacific, and to keep an eye on the rise of Brazil in case it gets any ideas about its influence in the Caribbean Sea. Economically the United States will also compete with China throughout Latin America for influence, but only in Cuba would Washington pull out all the stops to ensure it dominates the post-Castro/ Communist era. The proximity of Cuba to Florida, the historic relationship (albeit mixed), and Chinese pragmatism should be enough to ensure that the United States will be the dominant power in the new Cuba.

[…]

In Iraq, Afghanistan, and elsewhere, the United States underestimated the mentality and strength of small powers and of tribes. The Americans’ own history of physical security and unity may have led them to overestimate the power of their democratic rationalist argument, which believes that compromise, hard work, and even voting would triumph over atavistic, deep-seated historical fears of “the other,” be they Sunni, Shia, Kurd, Arab, Muslim, or Christian. They assumed people would want to come together, whereas in fact many dare not try and would prefer to live apart because of their experiences.

[…]

For thirty years it has been fashionable to predict the imminent or ongoing decline of the United States. This is as wrong now as it was in the past. The planet’s most successful country is about to become self-sufficient in energy, it remains the preeminent economic power, and it spends more on research and development for its military than the overall military budget of all the other NATO countries combined. Its population is not aging as in Europe and Japan, and a 2013 Gallup Poll showed that 25 percent of all people hoping to emigrate put the United States as their first choice of destination. In the same year, Shanghai University listed what its experts judged the top-twenty universities of the world: seventeen were in the United States.

Drug policy reform advocates hoped the first-in-the-nation decriminalization experiment would become a model

Tuesday, April 1st, 2025

In September, in a stunning reversal of policy for the Pacific north-west state, Oregon enacted legislation turning low-level drug possession into a more serious crime punishable by up to 180 days in jail:

Just four years ago, Oregon voters passed Measure 110, a groundbreaking drug decriminalization measure that abandoned jail sentences for possessing small amounts of drugs and imposed an infraction citation instead. Passed on the heels of Black Lives Matter uprisings, the measure aimed to treat addiction as a disease instead of a crime, prioritize services and recovery over jail, reduce overcrowding behind bars and help address racial disparities in policing and prosecutions.

At the time, Oregon was grappling with rising overdoses. It ranked second nationally for drug addiction rates and worst in the US for access to treatment. The problem was systemic, rooted in decades of failure to invest in the level of behavioral health services needed for people with mental illnesses and addiction. Measure 110 called for an infusion of $302m for addiction recovery and harm reduction services, with a focus on underserved communities, including Black and Indigenous people impacted by criminalization.

Drug policy reform advocates hoped the first-in-the-nation decriminalization experiment would become a model.

[…]

From September, when the new law was enacted, through 26 March, the Medford police force carried out 902 drug possession arrests — more than double the number of cases in Portland (a city with seven times the population). Jackson county has logged 1,170 arrests total.

[…]

One of the livability team’s main priorities has been clearing homeless encampments, and as Verling drove his patrol car onto a pedestrian greenway, the impact was clear. During the pandemic, encampments were a common site. Now, there were few visible signs of homelessness. Several locals were jogging.

This seems like a Rorschach test:

The state’s affordable housing shortage is the primary driver of homelessness, with over 27% of renters facing severely unaffordable rent, forced to spend half or more of their income on housing. Some unhoused people like Nikki come from out of state in hopes of better services. Her main motivation, she said, was healthcare: she’s a transgender woman, and her deep-red home state of Missouri had become a leader in anti-trans laws and medical restrictions. But she also liked the environment of Medford, in an area known as the Rogue Valley. There’s a backdrop of mountain ranges, and a greenway bike path connecting local cities.

“It’s been awesome living here, and it’s been shit,” said Nikki, who asked to use a nickname as she talked openly about drug use. She said she regularly uses meth and has done stints in rehab that didn’t last.

She said she had spent time in the county jail when she was picked up on warrants, forced into the men’s section. For people with serious addictions, detox in jail is “horror beyond what you can imagine”, she said. Incarceration can also increase overdose risks when people are released with lower tolerance.

Now, Nikki tries to sleep in hidden corners in the woods where police won’t bother her – “out of sight, out of mind”.