Two Patients Got Cancer From Transplant

Thursday, February 6th, 2003

I thought it was bad to get a deadly nut allergy from a transplant, but, as Two Patients Got Cancer From Transplant points out, it can be a whole lot worse:

Transfer of cancer from a donated organ to a transplant patient is rare, and the chances of it occurring long after the donor was treated were thought to be extremely unlikely. The longest known interval in a donor-related melanoma was eight years between surgery and transplant.

But in Thursday’s New England Journal of Medicine, researchers said two patients got cancer from a donor who had a melanoma skin lesion removed 16 years earlier and was thought to be cancer-free.

Melanoma cells had apparently been dormant in the donor’s kidneys until the transplant, explained Dr. Rona M. MacKie, who treated the recipients. The cancer cells flourished because medicines given to the patients to prevent rejection of the transplants had suppressed their disease-fighting immune systems.

The melanoma came back after 16 years.

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