I remember when Foldit was new:
Foldit is the granddaddy of crowd-sourced research games and has proven that games are a viable way to get results. Players were able to discover the structure of a monkey HIV virus, a problem that had stumped scientists for over ten years, in just ten days. The game itself is a 3D folding puzzle. Players are challenged to fold proteins into compact designs and are scored on various criteria like size and whether hydrophobic side chains are buried inside the structure. Players can work alone or with teams, to compete in puzzles and challenges.
Now there are many such games that let you do real-life science.