FDA OKs Lizard-Derived Shot for Diabetes

Saturday, April 30th, 2005

FDA OKs Lizard-Derived Shot for Diabetes:

Type 2 diabetics got a new option to help control their blood sugar Friday, a drug derived from the saliva of the Gila monster — but one that must be injected twice a day.

The Food and Drug Administration approved Byetta, known chemically as exenatide, the first in a new class of medications for Type 2 diabetes — but for now, it’s supposed to be used together with older diabetes drugs, not alone.
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The most common, drugs called sulfonylureas, spur the body to produce more insulin.

When those drugs fail, adding Byetta to them offers patients a new option to try before resorting to injections of insulin.

Byetta is the first so-called “incretin mimetic,” meaning it mimics action of a hormone called GLP-1 that’s secreted by the gut to spur insulin production after a meal — but only when blood sugar is high.

That’s important, noted FDA metabolic drugs chief Dr. David Orloff, because other diabetes drugs spur insulin secretion even if blood sugar already is low, leading to the risk of hypoglycemia.

Byetta is a synthetic version of a protein found in the saliva of the Gila monster that works similarly to the human GLP-1.

No mention of Dr. Curtis Connors

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