Sticky molecule may hold key to nerve disorders

Tuesday, December 4th, 2007

Sticky molecule may hold key to nerve disorders:

A sticky molecule previously linked to inflammation also helps seal vital insulation around peripheral nerves, making it a potential target for new drugs against nerve disorders, scientists said on Thursday.

The latest research suggests the molecule, known as JAM-C, could be a key player in regulating the way nerves work.

In genetically modified mice without the adhesion molecule, the myelin insulation sheath protecting nerves deteriorates and the animals experience faulty nerve firing, muscle weakness and a shortened stride, researchers reported in the journal Science.

The team also found that nerves of patients with certain peripheral nerve disorders had defective JAM-C.

Leave a Reply