How sunshine triggers skin repair

Monday, January 29th, 2007

Rachel Nowak explains how sunshine triggers skin repair:

A blast of sunshine could help fight skin diseases and cancer by attracting immune cells to the skin surface, according to a new study.

Eugene Butcher at Stanford University in California, US, and colleagues discovered an interesting immune process in human skin. Immune cells in the skin, called dendritic cells, convert vitamin D3 (produced in exposed skin in response to sunlight) into its active form.

This “active” vitamin D3 then causes T-cells to make surface changes that allow them to migrate to the uppermost layer of the skin, Butcher’s team found. T-cells are the immune cells that destroy damaged and infected cells, and they also regulate other immune cells.

The findings explain how T-cells “know” to go to the skin’s surface once the skin has suffered some sun-induced DNA-damage, the researchers say.

“Sunshine is good for you, as long as it’s not too much,” says team member Hekla Sigmundsdottir.

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