The anti-allergy drug Benadryl, which causes drowsiness, is also sold — at twice the dose — as the sleeping pill Unisom. Now it looks like diphenhydramine, the active ingredient, does not help infants sleep through the night. From Study nixes Benadryl for putting babies to sleep:
An antihistamine most commonly sold as Benadryl does little to help infants sleep through the night even though parents and some doctors think it does, according to a study published on Monday.Researchers at The Johns Hopkins School of Medicine, Baltimore, said they based the findings on a test of 44 children age 6 to 15 months, whose parents had reported they woke up in their cribs two or more times a night.
In tests conducted in 2004 and 2005, some of the children were given diphenhydramine as the medicine is known and others an inert placebo. The parents were then asked to keep track of the children’s sleep habits.
Three of 22 children in the placebo group and one of 22 in the group that received the drug had fewer nighttime wake-ups, the parents reported. And there was no difference between the two groups in how happy the parents were with their children’s sleep at any point during the study.