When fed plasmalogens, aged mice perform more like young mice

Wednesday, May 25th, 2022

Researchers from Xi’an Jiaotong-Liverpool University, Stanford University, Shanghai Jiao tong University, and the University of Chinese Academy of Sciences report that plasmologens (found in sea squirts) reverse some signs of aging — in mice:

The effects of the plasmalogen supplement on learning and memory were tested by training mice to use a Morris water maze — a pool of water that contains a platform that serves as a resting area. Generally, mice do not like to swim, so over five days of training, they remember where the platform is and swim directly to it as soon as they are in the pool. However, older mice take longer to find the platform after the same amount of training.

Astonishingly, when fed with plasmalogens, aged mice perform more like young mice, finding the platform much quicker than the control group of aged mice that have not been given the supplement.

To find the reason for the improvement shown by plasmalogen-fed mice, the researchers took a closer look at changes happening within the brain. They found that mice that were fed the plasmalogen supplement had a higher number and quality of synapses—the connections between neurons—than the aged mice not given the supplements.

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