“Modern attempts to eradicate h pylori use “triple therapy” of two different antibiotics plus a PPI, taken simultaneously, all for a unusually long period of time (one to two weeks). If you just give a patient a random antibiotic for some other disease, that’s not going to produce astounding results: you need the PPI to alter the transport of the antibiotic and prevent it from getting immediately broken down in the acidic environment of the stomach, and you need both antibiotics in case the bacteria develop resistance to one. Although some doctors probably got lucky and eliminated h pylori by chance, it’s not like every time anyone took an antibiotic it was curing their stomach ulcers and no one noticed.”

“Why else didn’t people catch onto h pylori’s role in stomach ulcers quicker? Well, at least 80% of people with h pylori don’t have ulcers or any symptoms whatsoever, and 20% of people with ulcers don’t have h pylori, so that’s going to confuse people. Second, h pylori is hard to stain and very hard to culture, so all you have are these Bigfoot-esque rumors of “I saw this bacterium in the stomach…I think…no, I don’t have any to show you.” A bunch of studies looked for bacteria in the stomach and find none, because of previously mentioned staining and culturing problems. And whenever people tried treating ulcers with antibiotics – and they did do the studies – they get equivocal results because they weren’t using the exact right drug combo to hit h pylori and keep it gone. The first person to successfully culture h pylori was the guy who won the Nobel Prize for discovering it.”